Brief Answer: Usually subsides in 4-6 weeks. Detailed Answer: Hello, Thanks for posting your query. The side effects of Depakote ER like body aches and pains are minor and usually self limiting side effects. It takes 4-6 weeks for these to subside spontaneously. In few cases it can be associated with osteopenia where such pains are persistent. It is best to get your serum calcium and Vitamin D3 levels evaluated to rule out osteopenia. Till then you can start with a mild pain killer like acetaminophen for symptomatic relief. I hope this answers your query. In case you have additional questions or doubts, you can forward them to me, and I shall be glad to help you out. Wishing you good health. Regards. Dr. Praveen Tayal. For future query, you can directly approach me through my profile URL http://bit.ly/Dr-Praveen-Tayal

---