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How Long Does Single Pill Of Misoprostol Take To Show Effect?

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Posted on Wed, 1 Apr 2015
Question: Hi,
I searle 1461 by mouth on Thursday last week. To this day no bleeding. Please advice?
doctor
Answered by Dr. Nidhi Setia (25 minutes later)
Brief Answer:
inadequate dose.

Detailed Answer:
Hello
Welcome here.

Searle 1461 is misoprostol.

Usually for abortion, mifepristone and misoprostol both are to be taken. Single pill of misoprostol can not cause abortion.

'Mifepristone 1 tablet by mouth alongwith 2 tablets misoprostol placed intravaginally, followed by placing another 2 tablets of misoprostol intravaginally after 12 hours'- this is the usual drug protocol for abortion.

Gestational sac is usually visible after 5 weeks of pregnancy.
Also, Go for transvaginal ultrasound to rule out tubal pregnancy.

Kindly discuss this with your doctor. Donot take any of the drugs I listed above, on your own.

Hope this helps.
Feel free to ask further.

Thanks.
Above answer was peer-reviewed by : Dr. Pradeep Vitta
doctor
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Follow up: Dr. Nidhi Setia (38 minutes later)
I went back to see my doc and he decided to repeat the dose 4 misoprostal then 3 pills again after 6hrs , repeat 3 pills after 6 hours again. Please advice.
doctor
Answered by Dr. Nidhi Setia (1 hour later)
Brief Answer:
that is quite high dose of misoprostol.

Detailed Answer:
Thanks for the follow-up query.

That would be too high dose in my opinion.

The mifepristone drug is important as it facilitates placental separation from endometrium.

Misoprostol increases uterine contractions and thus help in expulsion of conception products.
Higher than required doses of misoprostol can cause excessive bleeding and abdominal cramps due to inncreased uterine contraction.

I usually prefer the dose regime as I described in earlier answer.

Kindly discuss about these effects of misoprostol with your doctor and then proceed further. A second opinion can be considered.

Hope this helps.

Wish you good health.

Thanks.
Above answer was peer-reviewed by : Dr. Shanthi.E
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Answered by
Dr.
Dr. Nidhi Setia

OBGYN

Practicing since :2009

Answered : 761 Questions

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How Long Does Single Pill Of Misoprostol Take To Show Effect?

Brief Answer: inadequate dose. Detailed Answer: Hello Welcome here. Searle 1461 is misoprostol. Usually for abortion, mifepristone and misoprostol both are to be taken. Single pill of misoprostol can not cause abortion. 'Mifepristone 1 tablet by mouth alongwith 2 tablets misoprostol placed intravaginally, followed by placing another 2 tablets of misoprostol intravaginally after 12 hours'- this is the usual drug protocol for abortion. Gestational sac is usually visible after 5 weeks of pregnancy. Also, Go for transvaginal ultrasound to rule out tubal pregnancy. Kindly discuss this with your doctor. Donot take any of the drugs I listed above, on your own. Hope this helps. Feel free to ask further. Thanks.