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I Was Given Compazine For A Bad Headache And Had

Posted on Thu, 18 Oct 2018

Question: I was given Compazine for a bad headache and had a very strong reaction of body twitching both legs and arms. Also was given Benadryl
I take ropinerol for restless leg
Since taking Compazine Monday I have been unable to sleep much because ropinerol does not seem to be working. Suggestions?

Answered by Dr. Dr. Erion Spaho (45 minutes later)

Brief Answer:
There is interaction between Compazine and Ropinirole.

Detailed Answer:
Hello and welcome to "Ask a Doctor" service.

I have read your query and here is my advice.

Compazine and ropinirole shouldn't be used together because of the interaction between them.

Compazine decreases the effects of Ropinirole by pharmacodynamic antagonism.

So, I suggest you to discuss with your Doctor about substitution of Compazine.

Hope you found the answer helpful.

Let me know if I can assist you further.

Above answer was peer-reviewed by : Dr. Prasad

Follow up: Dr. Dr. Erion Spaho (7 hours later)

Compazine was a one time dose
My question is, based on the extreme reaction I had, requiring 2 doses on Ativan and some ropinerole before the massive twitching subsided, how long might the effects last..?
I have had insomnia and twitching since Monday in spite of taking the normal dose of ropinerol

Answered by Dr. Dr. Erion Spaho (16 hours later)

Brief Answer:
Symptoms should subside in short time.

Detailed Answer:
Welcome back.

In my opinion, since there was only one dose of Compazine, adverse effects related to the interaction between drugs should subside in one week or two.

Hope I've helped you.

Take care.

Above answer was peer-reviewed by : Dr. Raju A.T