I’m On A Paliperidone Depot, Quetiapine, Procyclidine And Mirtazapine. Is

Posted on Tue, 3 Sep 2019

Question: I’m on a paliperidone depot, quetiapine, procyclidine and mirtazapine. Is it safe to take ondansetron?

Answered by Dr. Dr. Antoneta Zotaj (55 minutes later)

Brief Answer:
There is increased risk of arrhythmia (irregular heartbeat) if you add ondansetron

Detailed Answer:
Hello and welcome to "Ask a Doctor" service,

Ondansetron interacts with paliperidone and quetiapine as all these three medications do affect the QTc interval in the heart and increasing the risk for arrhythmias.
It is considered a serious interaction and alternative treatment is recommended.
I would recommend you to talk to your doctor related to the risk of arrhythmias if you add ondansetron to your treatment.

I hope this answers your query.
I remain at your disposal in case further medical assistance is needed.

Regards,
Dr. Antoneta Zotaj
General and Family Physician

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Above answer was peer-reviewed by : Dr. Raju A.T