In A Patient With Myelodysplastic Syndrome , Is Management The

Posted on Tue, 7 Jan 2020

Question: In a patient with myelodysplastic syndrome, is management the same with a platelet count of 1.41 million vs 1.15 million? Any treatment differences?

Answered by Dr. Indranil Ghosh (2 hours later)

Brief Answer:
No there should not be

Detailed Answer:
Hi
Thanks for your query.

Platelet count of >100,000/uL is sufficient, even in MDS patient, so 140,000 or 115,000 won't make any difference to treatment.

Hope this helps.
Regards

Above answer was peer-reviewed by : Dr. Kampana

Follow up: Dr. Indranil Ghosh (5 hours later)

This is thromcytosis. These platelet counts are over 1 million. Do they both need to be lowered using hydroxyurea and aspirin or would the higher one have a different treatment than the lower one?

Answered by Dr. Indranil Ghosh (12 minutes later)

Brief Answer:
Aspirin should be enough

Detailed Answer:
MDS patients rarely have such high platelets but possible. These patients don't have much excess bleeding or thrombosis risk. So Aspirin alone should be enough for both patients.

But there is no clear guideline on managing platelet count in these patients.

Rest of MDS management as per risk group should continue.

Regards

Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Yogesh D