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Is 1 In 282 A High Risk Of Down Syndrome?
Posted on
Tue, 4 Nov 2014
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Tue, 4 Nov 2014
Answered on
Fri, 28 Nov 2014
Last reviewed on
Question : My provider called me yesterday said: the part of test NT and NTD labs result is high risk -1in 282. I am worry about it .Now, I am waiting for my scond test -
What exactly is your question?
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
My question is : 1in 282 is a high risk of Donw sydrome ? I am pregnat 12weeks . I am 37 years old
Brief Answer:
Risk higher. Confirmation required
Detailed Answer:
Thanks for posting on HealthCareMagic. NTD stands for neural tube defect and NT for nuchal translucency, both of which form the biophysical markers for screening of Down syndrome. A higher maternal age as in your case increases the possibility of Down syndrome.
In the first trimester screen blood test for Pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (hCG) as either free beta subunit or total hCG, along with ultrasound for nuchal translucency are done, and a mathematical calculation is done based on that. Probability of 1 in 300 or higher as in your case indicates a higher likelihood of Down syndrome. But it has to be confirmed by chorionic villus sampling (CVS) in the first trimester or amniocentesis in the second trimester. Are you talking about aminocentesis as your second test? If not, you have to go for aminocentesis or even better chorionic villus sampling to be sure.
Risk higher. Confirmation required
Detailed Answer:
Thanks for posting on HealthCareMagic. NTD stands for neural tube defect and NT for nuchal translucency, both of which form the biophysical markers for screening of Down syndrome. A higher maternal age as in your case increases the possibility of Down syndrome.
In the first trimester screen blood test for Pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (hCG) as either free beta subunit or total hCG, along with ultrasound for nuchal translucency are done, and a mathematical calculation is done based on that. Probability of 1 in 300 or higher as in your case indicates a higher likelihood of Down syndrome. But it has to be confirmed by chorionic villus sampling (CVS) in the first trimester or amniocentesis in the second trimester. Are you talking about aminocentesis as your second test? If not, you have to go for aminocentesis or even better chorionic villus sampling to be sure.
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
Thank you so much!
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Detailed Answer:
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Above answer was peer-reviewed by :
Dr. Raju A.T
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