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Is A/g Ratio Of 2.8 A Cause For Concern?

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Posted on Tue, 15 Sep 2015
Question: My A/ G ratio was slightly elevated 2.8 it was 3.1 6 months ago.
Albumin is 4.5
Globulin 1.6
Total protein 6.1
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Answered by Dr. Michelle Gibson James (1 hour later)
Brief Answer:
decreasing, so that is good, also only slightly above norm

Detailed Answer:
HI, thanks for using healthcare magic

The normal A/g ratio can vary slightly from one lab to the next but is generally approx 0.8 to 2.0

A/g ratio can be high if the albumin is high relative to the globulin or commonly if the globulin is low relative to the albumin.

The value is closer to normal now than it was a few months ago, this is good and likely means that it is not related to any serious condition.

Significant increased ratio may be due to different possible causes such as: (1) low levels of thyroid hormone
(2)liver disease
(3)use of steroid medications
(4)high protein diet
(5)conditions affecting the immune system where there is decreased production of immunoglobulins

Immunoglobins are a type of protein that are involved in the immune response, there are different types of immune globlulins

The increase is only mild and the other values are essentially normal, so you may want to consider repeating at a later date to see if there is any change.


If you are not comfortable and wish to assess now or the repeat is also elevated then you can consider:
Thyroid function tests and liver function tests can be done to assess these areas and a serum protein electrophoresis can also be requested to look.
Serum protein electrophoresis would take a look at the specific globulins types

I hope this helps, feel free to ask any other questions



Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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Is A/g Ratio Of 2.8 A Cause For Concern?

Brief Answer: decreasing, so that is good, also only slightly above norm Detailed Answer: HI, thanks for using healthcare magic The normal A/g ratio can vary slightly from one lab to the next but is generally approx 0.8 to 2.0 A/g ratio can be high if the albumin is high relative to the globulin or commonly if the globulin is low relative to the albumin. The value is closer to normal now than it was a few months ago, this is good and likely means that it is not related to any serious condition. Significant increased ratio may be due to different possible causes such as: (1) low levels of thyroid hormone (2)liver disease (3)use of steroid medications (4)high protein diet (5)conditions affecting the immune system where there is decreased production of immunoglobulins Immunoglobins are a type of protein that are involved in the immune response, there are different types of immune globlulins The increase is only mild and the other values are essentially normal, so you may want to consider repeating at a later date to see if there is any change. If you are not comfortable and wish to assess now or the repeat is also elevated then you can consider: Thyroid function tests and liver function tests can be done to assess these areas and a serum protein electrophoresis can also be requested to look. Serum protein electrophoresis would take a look at the specific globulins types I hope this helps, feel free to ask any other questions