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Is Epogen Safe To Take For Anemia With Kidney Injury?
Question: My question can Epogen be safely used to correct anemia in a patient with acute kidney injury without making their kidney injury worse? I know it's used in patients with CKD, but what about patients with acute component to their kidney injury. I was told if there is an AKI, giving them Epogen could worsen their kidney disease by stressing the kidney more.
Brief Answer:
No priblem
Detailed Answer:
there is no problem if anaemic patient is given Epo (short for Epogen). Epo is hormone that is synthesized in kidneys normally and decreases in concentrations in blood when ever the kidneys are diseased.
The previous and logical thinking is that in AKI , the kidneys are temporarily shut down and they regain function very soon and all the functions if kidneys are restored immediately, also the Epo synthesis .
But several studies related to use of Epo in Icu with or with out renal shut didn't (regain their function) and associated with anemia, Epo supplementation reduced the number of transfusions but did not affect the outcome.
Hence the Epo can be given safely in pattients with AKI with out any major adverse effect.
However one should be aware of the adverse effects of Epo when it is being used in CKD such as worsening hypertension etc. it can produce seizure in those who are vulnerable.
Other wise no major complications known or contraindication associated with Epo
No priblem
Detailed Answer:
there is no problem if anaemic patient is given Epo (short for Epogen). Epo is hormone that is synthesized in kidneys normally and decreases in concentrations in blood when ever the kidneys are diseased.
The previous and logical thinking is that in AKI , the kidneys are temporarily shut down and they regain function very soon and all the functions if kidneys are restored immediately, also the Epo synthesis .
But several studies related to use of Epo in Icu with or with out renal shut didn't (regain their function) and associated with anemia, Epo supplementation reduced the number of transfusions but did not affect the outcome.
Hence the Epo can be given safely in pattients with AKI with out any major adverse effect.
However one should be aware of the adverse effects of Epo when it is being used in CKD such as worsening hypertension etc. it can produce seizure in those who are vulnerable.
Other wise no major complications known or contraindication associated with Epo
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
Brief Answer:
no
Detailed Answer:
It has got no adverse effect on kidney function. You can give it safely and see the at the other known adverse effects are monitored
no
Detailed Answer:
It has got no adverse effect on kidney function. You can give it safely and see the at the other known adverse effects are monitored
Note: For further queries related to kidney problems and comprehensive renal care, talk to a Nephrologist. Click here to Book a Consultation.
Above answer was peer-reviewed by :
Dr. Bhagyalaxmi Nalaparaju
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