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Is Ibuprofen Safe For Menstrual Cramps While Having FVL Mutation?
Posted on
Sat, 21 Nov 2015
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Fri, 20 Nov 2015
Answered on
Mon, 7 Dec 2015
Last reviewed on
Question : I have Factor V Leiden Heterozygous. I have never had a blood clot or had to take blood thinners. I wanted to see if it is safe to take Ibuprofen for menstrual cramping with having Factor V? I've been taking it and then thought maybe I should find out if it's something that could increase the risks of clots or if it's OK to use for this reason.
Brief Answer:
it can be used
Detailed Answer:
Hello,
having Leiden factor in heterozygous form increases the risk of thrombosis 5-7 times. Using NSAIDs may increase the risk too (up to x2). Among various NSAIDs, the selective COX-2 inhibitors seem to be the most dangerous. The rest (like ibuprofen) are less likely to cause thrombosis. Aspirin actually protects against thrombosis!
The absolute risk for thrombosis is low for heterozygous Leiden patients.
So in conclusion, although the risk is higher with your condition, taking ibuprofen cannot be prohibited.
I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.
Kind Regards!
it can be used
Detailed Answer:
Hello,
having Leiden factor in heterozygous form increases the risk of thrombosis 5-7 times. Using NSAIDs may increase the risk too (up to x2). Among various NSAIDs, the selective COX-2 inhibitors seem to be the most dangerous. The rest (like ibuprofen) are less likely to cause thrombosis. Aspirin actually protects against thrombosis!
The absolute risk for thrombosis is low for heterozygous Leiden patients.
So in conclusion, although the risk is higher with your condition, taking ibuprofen cannot be prohibited.
I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.
Kind Regards!
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
So just so I understand correctly, I can take it for a few days during menstruation safely?
Brief Answer:
the absolute risk low
Detailed Answer:
The answer is that you can take it because the absolute risk is low, despite the fact that the relative risk may be higher. Paracetamol (acetaminophen) would be a much better choice in many ways, although less effective than ibuprofen.
More important things to consider regarding thrombosis risk include contraceptives and smoking.
Kind Regards!
the absolute risk low
Detailed Answer:
The answer is that you can take it because the absolute risk is low, despite the fact that the relative risk may be higher. Paracetamol (acetaminophen) would be a much better choice in many ways, although less effective than ibuprofen.
More important things to consider regarding thrombosis risk include contraceptives and smoking.
Kind Regards!
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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