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Is Vraylar Effective In Treating Negative Symptoms Of Schizophrenia?
Brief Answer:
The drug has great potential in negative symptoms
Detailed Answer:
Hello thanks for asking from HCM
Cariprazine is a newer drug and if we consider its efficacy in negative symptoms then in a lot of studies the drug showed greater efficacy in controlling negative symptoms of schizophrenia compared to placebo and other drugs.
I couldn't find studies comparing Cariprazine directly with Olanzapine or Aripiprazole. But in a number of studies it showed greater efficacy than Risperidone (which is similar to Olanzapine or Aripiprazole).
So we can say based upon initial studies that the drug has promising efficacy in negative symptoms of schizophrenia or depression.
Thanks and take care
The drug has great potential in negative symptoms
Detailed Answer:
Hello thanks for asking from HCM
Cariprazine is a newer drug and if we consider its efficacy in negative symptoms then in a lot of studies the drug showed greater efficacy in controlling negative symptoms of schizophrenia compared to placebo and other drugs.
I couldn't find studies comparing Cariprazine directly with Olanzapine or Aripiprazole. But in a number of studies it showed greater efficacy than Risperidone (which is similar to Olanzapine or Aripiprazole).
So we can say based upon initial studies that the drug has promising efficacy in negative symptoms of schizophrenia or depression.
Thanks and take care
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
i have this study on internet. the study compare cariprazine with risperdone. the mean baseline for negative symptoms for 2 groups(each group contain 230 patients) was 28 pts. after 14 weeks the score decrease 7.4 pts for respiredone and 8.9 pts for cariprazine. how to calculate the improvement in each drug for negative symptoms
Brief Answer:
PANSS was used.
Detailed Answer:
Hello again
In that particular study a scale was used to compare the effectiveness. The PANSS was used and in that scale negative symptoms are in range of 7 to 49. The scale was administered at start of study and at 14 weeks it resulted in reduction of negative symptoms score by 8.9 points compared to 7.4 points (mean) with Risperidone.
I hope you are understanding this.
PANSS was used.
Detailed Answer:
Hello again
In that particular study a scale was used to compare the effectiveness. The PANSS was used and in that scale negative symptoms are in range of 7 to 49. The scale was administered at start of study and at 14 weeks it resulted in reduction of negative symptoms score by 8.9 points compared to 7.4 points (mean) with Risperidone.
I hope you are understanding this.
Above answer was peer-reviewed by :
Dr. Raju A.T
yes but my question we can say to calculate the improvement in %: (18÷49)-1=63% improvement on cariprazine
Brief Answer:
The exact percentage is difficult to be calculated.
Detailed Answer:
Hello again
The study consisted of only 460 subjects and its not possible to find exact percentage of improvement. But yes we can say the difference in improvement of negative symptoms in PANSS scale was statistically significant. This means the drug can become one of main drug for treatment of negative symptoms.
Thanks.
The exact percentage is difficult to be calculated.
Detailed Answer:
Hello again
The study consisted of only 460 subjects and its not possible to find exact percentage of improvement. But yes we can say the difference in improvement of negative symptoms in PANSS scale was statistically significant. This means the drug can become one of main drug for treatment of negative symptoms.
Thanks.
Note: For further guidance on mental health, Click here.
Above answer was peer-reviewed by :
Dr. Kampana
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