Is It Advisable To Take Depakote And Trazodone While On Harvoni?

Posted on Sat, 9 Jan 2016

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Sat, 9 Jan 2016 Answered on

Sat, 6 Feb 2016 Last reviewed on

Question : can a patient on harvoni take Depakote and trazodone

Answered by Dr. Sandip Kabra (1 hour later)

Brief Answer:
Can be taken since there is no clear evidance.

Detailed Answer:
Hello,
Welcome to HCM.

Harvoni (ledipasvir / sofosbuvir) is in the combinations drug of antiviral group whereas Trazodone (antidepressants) is used to treat anxiety and insomnia related to depression.

And Depakote (divalproex sodium) is a prescription based anti-epileptic drug used to treat epilepsy, some mood disorders (like bipolar disorder) and migraine headaches.

However,there is no clear cut clinical evidence of any drug interaction between Harvoni and Depakote with Trazodone,so you may take them.

But choose different timing for depakote and trazodone since both these drugs have same side effects like giddiness,lack of concentration and drowsiness.

You may consult your doctor for time adjustment who will know about it and may better guide you.

Hope this helps.

Regards,

Dr.Sandip Kabra

Above answer was peer-reviewed by : Dr. Sonia Raina