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Is It Possible For HIV RNA Test Not To Detect Virus If The Viral Load Is Very Low?
Question: Dear Doctor,
I hope you still remember me. I contacted you about two weeks ago.
I have a question regarding my HIV-RNA (Viraload) test result.
Would it be possible if the viraload is very low, that the RNA test could not detect it??
The lab are using 2 methods of HIV-RNA Test.
1. Conventional (Instrument: Abbott M2000, Detect level: 4,00X10^1 copies/mL)
2. S I (Instrument: Abbott M2000, Detect Level: 6,96x10^1 IU/mL)
Can you please advise?
I have lost about 5kg cause of stress in about 10 days, does is effect my CD%?
My CD% is 33% from the lab benchmark range of 31-60%.
Can you help to advise, Doctor?
I am still a little confused right now.
Thank you for your help, Doctor.
I hope you still remember me. I contacted you about two weeks ago.
I have a question regarding my HIV-RNA (Viraload) test result.
Would it be possible if the viraload is very low, that the RNA test could not detect it??
The lab are using 2 methods of HIV-RNA Test.
1. Conventional (Instrument: Abbott M2000, Detect level: 4,00X10^1 copies/mL)
2. S I (Instrument: Abbott M2000, Detect Level: 6,96x10^1 IU/mL)
Can you please advise?
I have lost about 5kg cause of stress in about 10 days, does is effect my CD%?
My CD% is 33% from the lab benchmark range of 31-60%.
Can you help to advise, Doctor?
I am still a little confused right now.
Thank you for your help, Doctor.
Brief Answer:
Yes it might be possible if viral load count is very low below 50 or less.
Detailed Answer:
Dear XXXX, first of all I will advice you again not to take too much of stress as it has already it's effect on your health as you had lost 5 kg of weight. As far as your query is concerned, I will say yes, it might be possible sometimes that if viral load count is very low below 50 or less than the tests can't pick it. But the tests you have mentioned have the sensitivity to detect even 40 copies/ml. So I think you need not to worry regarding this. In addition I will say your CD4 is good but if you continue to take so much of stress than it can fall what I don't want for you. So be relaxed and get in touch anytime you feel disturbed. Thank you very much.
Yes it might be possible if viral load count is very low below 50 or less.
Detailed Answer:
Dear XXXX, first of all I will advice you again not to take too much of stress as it has already it's effect on your health as you had lost 5 kg of weight. As far as your query is concerned, I will say yes, it might be possible sometimes that if viral load count is very low below 50 or less than the tests can't pick it. But the tests you have mentioned have the sensitivity to detect even 40 copies/ml. So I think you need not to worry regarding this. In addition I will say your CD4 is good but if you continue to take so much of stress than it can fall what I don't want for you. So be relaxed and get in touch anytime you feel disturbed. Thank you very much.
Above answer was peer-reviewed by :
Dr. Prasad
Dear Doctor,
For HIV-RNA test, how early this test able to perform post-exposure?? How fast the virus multiply normally?
I am very confused as my 1st test on 4th May 2015 says Reactive based on CMIA, Immunochromatography, and XXXXXXX
And, on the 11th May 2015 blood withdrawal result, 3 rapid test says Non-Reactive and 1 rapid test says Indeterminate (based on twice performed test). And, the HIV Viral Load test says that "No Virus Detected"....
I am sorry Doctor if my question sound very redundant. As, i am totally lost and confused right now. Which result i should believe in???
For HIV-RNA test, how early this test able to perform post-exposure?? How fast the virus multiply normally?
I am very confused as my 1st test on 4th May 2015 says Reactive based on CMIA, Immunochromatography, and XXXXXXX
And, on the 11th May 2015 blood withdrawal result, 3 rapid test says Non-Reactive and 1 rapid test says Indeterminate (based on twice performed test). And, the HIV Viral Load test says that "No Virus Detected"....
I am sorry Doctor if my question sound very redundant. As, i am totally lost and confused right now. Which result i should believe in???
Brief Answer:
HIV RNA PCR is able to detect the virus post exposure earlier by 3-4 weeks.
Detailed Answer:
Dear XXXX, don't say sorry if you are confused and stressed I am always here to help you. HIV RNA PCR test is able to detect the virus in very early period after exposure by 3-4 weeks. As your three rapid tests are non-reactive and HIV viral load test is non-detectable than the probability of having an infection is nil or very less. You can believe your viral load test result and your CD4 count is also good. So, Avoid stress and take care of your health as it is very crucial for you. One more thing I am here to answer your questions till you feel completely satisfied and relaxed. So get back to me anytime if still any query remains. Thank You
HIV RNA PCR is able to detect the virus post exposure earlier by 3-4 weeks.
Detailed Answer:
Dear XXXX, don't say sorry if you are confused and stressed I am always here to help you. HIV RNA PCR test is able to detect the virus in very early period after exposure by 3-4 weeks. As your three rapid tests are non-reactive and HIV viral load test is non-detectable than the probability of having an infection is nil or very less. You can believe your viral load test result and your CD4 count is also good. So, Avoid stress and take care of your health as it is very crucial for you. One more thing I am here to answer your questions till you feel completely satisfied and relaxed. So get back to me anytime if still any query remains. Thank You
Above answer was peer-reviewed by :
Dr. Prasad
Dear Doctor...
Thank you for your prompt reply.
Shall i disregard my 4th May 2015 diagonse based on CMIA, Immunochromatography and ELSA/ELFA???
Thank you for your prompt reply.
Shall i disregard my 4th May 2015 diagonse based on CMIA, Immunochromatography and ELSA/ELFA???
Brief Answer:
Yes you can disregard as your viral load test result say no virus detected.
Detailed Answer:
Dear XXXX, I think now are completely satisfied and some what more relaxed about your confusion and I am very happy for that. In relation to your query I will say, yes you can disregard the result of CMIA, Immuno-chromatography because sometimes it came positive due to some technical or instrumental error and your viral load test result is also negative (no virus detected). Now, forget all these things and go ahead in your life with good health and positive attitude. Thank You and wishing you very happy life ahead.
Yes you can disregard as your viral load test result say no virus detected.
Detailed Answer:
Dear XXXX, I think now are completely satisfied and some what more relaxed about your confusion and I am very happy for that. In relation to your query I will say, yes you can disregard the result of CMIA, Immuno-chromatography because sometimes it came positive due to some technical or instrumental error and your viral load test result is also negative (no virus detected). Now, forget all these things and go ahead in your life with good health and positive attitude. Thank You and wishing you very happy life ahead.
Above answer was peer-reviewed by :
Dr. Shanthi.E
Dear Doctor,
Thank you for your kind explanantion.
My CD4 Absolut count is 364, and the lab benchmark is 410-1589
And my CD4% is 33%.
Shall i be worried about my CD4 Absolut count??
Need your advise.
Thank you
Thank you for your kind explanantion.
My CD4 Absolut count is 364, and the lab benchmark is 410-1589
And my CD4% is 33%.
Shall i be worried about my CD4 Absolut count??
Need your advise.
Thank you
Brief Answer:
No you need not to worry about your CD4 count at present as it is above 350
Detailed Answer:
Dear XXXX, the cut of point for CD4 count is 350 in case of HIV infection. As your viral load test result is negative and CD4 count is 364 than no need to worry at present. Another thing I want to say is stress has its own impact on CD4 count and it is clearly looking in your report. So once again my friend I will advice you to avoid any kind of stress as it is not good for your health in general also. Repeat your CD4 count after one months, it will be good enough. Thank You
No you need not to worry about your CD4 count at present as it is above 350
Detailed Answer:
Dear XXXX, the cut of point for CD4 count is 350 in case of HIV infection. As your viral load test result is negative and CD4 count is 364 than no need to worry at present. Another thing I want to say is stress has its own impact on CD4 count and it is clearly looking in your report. So once again my friend I will advice you to avoid any kind of stress as it is not good for your health in general also. Repeat your CD4 count after one months, it will be good enough. Thank You
Above answer was peer-reviewed by :
Dr. Prasad
Dear Doctor,
Thank you for your information.
My 1st lab where i took the blood test called me 30 minutes ago.
They withdraw my blood on 4th May 2015, and based on the CMIA method running twice, result is 1.56 and 1.51
They withdraw my blood again on 5th May 2015, and the CMIA method result is 1.48.
Any advice on this? Is these numbers saying like early infection???
Thank you Doctor.
Thank you for your information.
My 1st lab where i took the blood test called me 30 minutes ago.
They withdraw my blood on 4th May 2015, and based on the CMIA method running twice, result is 1.56 and 1.51
They withdraw my blood again on 5th May 2015, and the CMIA method result is 1.48.
Any advice on this? Is these numbers saying like early infection???
Thank you Doctor.
Brief Answer:
Yes these numbers are suggestive of an early infection but not in your case
Detailed Answer:
Dear XXXXX, CMIA test result is negative if reading is one or less. In your case it is 1.48 which might be suggestive of early infection. But as your viral load test result is negative I don't think CMIA result is reliable at present. I will advice you to repeat it at the end of three months after exposure as it is 99.99% accurate at three months. Thank You
Yes these numbers are suggestive of an early infection but not in your case
Detailed Answer:
Dear XXXXX, CMIA test result is negative if reading is one or less. In your case it is 1.48 which might be suggestive of early infection. But as your viral load test result is negative I don't think CMIA result is reliable at present. I will advice you to repeat it at the end of three months after exposure as it is 99.99% accurate at three months. Thank You
Above answer was peer-reviewed by :
Dr. Shanthi.E
Brief Answer:
Yes HIV RNA viral load test is more accurate than CMIA or western blot.
Detailed Answer:
Dear XXXX, Obviously HIV RNA viral load is more accurate than CMIA and also more reliable than western blot because both these are antibody detection tests rather than antigen detection test like HIV RNA PCR. Thank You
Yes HIV RNA viral load test is more accurate than CMIA or western blot.
Detailed Answer:
Dear XXXX, Obviously HIV RNA viral load is more accurate than CMIA and also more reliable than western blot because both these are antibody detection tests rather than antigen detection test like HIV RNA PCR. Thank You
Above answer was peer-reviewed by :
Dr. Shanthi.E
Dear Doctor...
It is such a relief to hear that the RNA viraload test is very accurate.
I am sorry for asking another question, lets assume that i am in the "early infection" stage, do the rapid test and the viraload test should be able to tell anything? Or, if it is too early, nothing can be detected??
Thank you doctor
It is such a relief to hear that the RNA viraload test is very accurate.
I am sorry for asking another question, lets assume that i am in the "early infection" stage, do the rapid test and the viraload test should be able to tell anything? Or, if it is too early, nothing can be detected??
Thank you doctor
Brief Answer:
In early infection stage viral load test is able to detect it by 3-4 weeks.
Detailed Answer:
Dear XXXXX, usually rapid tests for detection of antibodies which would appear in the blood by 6-8 weeks in the presence of infection and may be delayed up to three months. So in early infection stage rapid tests are not able to tell anything. But HIV viral load test is conclusive in earlier period by 3-4 weeks so it can tell if any infection is present or not. Sometimes when viral load is very low as below 50 or less it might be possible that even these tests can't detect this.
In early infection stage viral load test is able to detect it by 3-4 weeks.
Detailed Answer:
Dear XXXXX, usually rapid tests for detection of antibodies which would appear in the blood by 6-8 weeks in the presence of infection and may be delayed up to three months. So in early infection stage rapid tests are not able to tell anything. But HIV viral load test is conclusive in earlier period by 3-4 weeks so it can tell if any infection is present or not. Sometimes when viral load is very low as below 50 or less it might be possible that even these tests can't detect this.
Above answer was peer-reviewed by :
Dr. Shanthi.E
Dear Doctor....
To conclude....what is your angle perspective of my condition?
Do you think i am OK for now??
Does every month monitoring my CD4 would be helpful??
Shall i completely trust the result of the viraload test? Rather than trust the CMIA i took earlier this month??
Thank you Doctor.....
To conclude....what is your angle perspective of my condition?
Do you think i am OK for now??
Does every month monitoring my CD4 would be helpful??
Shall i completely trust the result of the viraload test? Rather than trust the CMIA i took earlier this month??
Thank you Doctor.....
Brief Answer:
Yes you are ok at present and you can trust the result of viral load test.
Detailed Answer:
Dear XXXX,
my perspective about your condition is that you are ok at present. You can definitely trust the result of viral load test and if you want to monitor your CD4 count you can do it monthly for first time than every 3 to 6 months. If still any query you can contact me anytime.
Thank you very much and wish you very happy life.
Yes you are ok at present and you can trust the result of viral load test.
Detailed Answer:
Dear XXXX,
my perspective about your condition is that you are ok at present. You can definitely trust the result of viral load test and if you want to monitor your CD4 count you can do it monthly for first time than every 3 to 6 months. If still any query you can contact me anytime.
Thank you very much and wish you very happy life.
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Dear Doctor...
I am very sorry if i disturb you again.
I have a few questions:
1. What is the best method to detect early infection? CMIA test or RNA viraload test?
2. Is it true that the RNA test may detect as early as 10 days post exposure??
I am still in the juggling and confused....it is just too many "what If" on my mind right now.
Thank you Doctor....
I am very sorry if i disturb you again.
I have a few questions:
1. What is the best method to detect early infection? CMIA test or RNA viraload test?
2. Is it true that the RNA test may detect as early as 10 days post exposure??
I am still in the juggling and confused....it is just too many "what If" on my mind right now.
Thank you Doctor....
Brief Answer:
RNA viral load is the best method to detect early HIV infection by 2 weeks.
Detailed Answer:
Dear XXXX, you are most welcome any time so don't say sorry. As you have asked among CMIA or RNA viral load test I will say RNA viral load test is the best method to detect early HIV infection because it is conclusive in earlier period after exposure usually within 2-4 weeks. So it is true that RNA test is able to detect the infection as early as 10 days post exposure. If still any doubt left in your mind please don't hesitate and get back to me. Thank you very much
RNA viral load is the best method to detect early HIV infection by 2 weeks.
Detailed Answer:
Dear XXXX, you are most welcome any time so don't say sorry. As you have asked among CMIA or RNA viral load test I will say RNA viral load test is the best method to detect early HIV infection because it is conclusive in earlier period after exposure usually within 2-4 weeks. So it is true that RNA test is able to detect the infection as early as 10 days post exposure. If still any doubt left in your mind please don't hesitate and get back to me. Thank you very much
Above answer was peer-reviewed by :
Dr. Prasad
Dear Dr. XXXXXXX ..
Good day to you.
First of all, my apology for sending you an email again.
I am just so paranoid and "lost"...and believe me...i am trying very very hard to move ON. I even see local doctor here, and they told me to "Moved ON" and trust the viral load result and CD4
I just need a second opinion from your angle about what has been juggling and disturbing my mind.
1. As you know, i took the 1st test on 4th of May 2015. The lab called me to withdraw another blood sample on 5th of May 2015. And the result based on CMIA, Immunochromatography and ELFA/ELSA is Reactive. Prior to blood sample taking, i went to the gym in the morning and took a packet of GNC supplements such as thermogenic, fat burner, and supplements to reduce excess water and drank whey protein. Does it make an effect on the result on the test??
2. I took the second test on 11th May 2015. I stopped eating those supplements since 6th May 2015. And, when they run Twice my blood sample using 4 types rapid test, 3 results in Non-Reactive and 1 result is Indeterminate. My question is, if my 1st test result says "Reactive", does the rapid test should says "Reactive" as well?? What could probably caused the different result?
3. I went online and read more about HIV-RNA test and found this website in Singapore (www.drtanandpartners.com). From the website says that HIV-RNA test is good to take between 10-12 days post exposure, and the result of HIV-RNA is claimed to be 100% accurate. Is it correct??
4. Let's assume my rapid tests are Reactive, does the HIV-RNA viraload will able to detect the presence of the virus even after 3 months?
5. My confusion is only that within a week period, the result are contradicting. The 1st lab inform me that my CMIA result is 1.48. If the CMIA resulting 1.48, does it mean the Viraload test should detect something??
6. Can i say that the viraload test is Conclude?? Which result i should trust, so i can really move ON.
Thank you Doctor, i am really sorry for the long mail, and apology if my questions seems redundant to you. I really want to make a new commitment and live a new life, and commit myself again solely for my wife.
Good day to you.
First of all, my apology for sending you an email again.
I am just so paranoid and "lost"...and believe me...i am trying very very hard to move ON. I even see local doctor here, and they told me to "Moved ON" and trust the viral load result and CD4
I just need a second opinion from your angle about what has been juggling and disturbing my mind.
1. As you know, i took the 1st test on 4th of May 2015. The lab called me to withdraw another blood sample on 5th of May 2015. And the result based on CMIA, Immunochromatography and ELFA/ELSA is Reactive. Prior to blood sample taking, i went to the gym in the morning and took a packet of GNC supplements such as thermogenic, fat burner, and supplements to reduce excess water and drank whey protein. Does it make an effect on the result on the test??
2. I took the second test on 11th May 2015. I stopped eating those supplements since 6th May 2015. And, when they run Twice my blood sample using 4 types rapid test, 3 results in Non-Reactive and 1 result is Indeterminate. My question is, if my 1st test result says "Reactive", does the rapid test should says "Reactive" as well?? What could probably caused the different result?
3. I went online and read more about HIV-RNA test and found this website in Singapore (www.drtanandpartners.com). From the website says that HIV-RNA test is good to take between 10-12 days post exposure, and the result of HIV-RNA is claimed to be 100% accurate. Is it correct??
4. Let's assume my rapid tests are Reactive, does the HIV-RNA viraload will able to detect the presence of the virus even after 3 months?
5. My confusion is only that within a week period, the result are contradicting. The 1st lab inform me that my CMIA result is 1.48. If the CMIA resulting 1.48, does it mean the Viraload test should detect something??
6. Can i say that the viraload test is Conclude?? Which result i should trust, so i can really move ON.
Thank you Doctor, i am really sorry for the long mail, and apology if my questions seems redundant to you. I really want to make a new commitment and live a new life, and commit myself again solely for my wife.
Brief Answer:
Yes you can definitely trust the result of viral load test and can move on.
Detailed Answer:
Dear XXXX, first of all I will say no need to paranoid and disturb your mind so much. As per your queries, GNC or other energy supplements like whey protein don't have any effect on the result of CMIA, ELISA or Immunoohromatography test. Second, different result of one of the rapid tests is mostly due to some instrumental or technical error as I had already told you earlier. Third, yes it is absolutely correct that the result of the HIV RNA test is claimed to be 100% accurate. Fourth, if your rapid tests are reactive than the HIV RNA viral load test will definitely be able to detect the presence of virus not only after 3 months even in earlier period by 3-4 weeks also. Fifth, as your CMIA test result is above 1 which might be suggestive of an early infection but it does not mean that the viral load test has to detect something because CMIA is less reliable and accurate than the viral load test result. Last but not the least I will say again yes the viral load test result is conclusive and you can trust it. So at the end again as your good friend I will advice you be ralxed and don't take so much of stress or tension. Go ahead in your life happily with a new commitment solely for your wife only. If still any questions left you can contact me again without any hesitation. Thank you very much
Yes you can definitely trust the result of viral load test and can move on.
Detailed Answer:
Dear XXXX, first of all I will say no need to paranoid and disturb your mind so much. As per your queries, GNC or other energy supplements like whey protein don't have any effect on the result of CMIA, ELISA or Immunoohromatography test. Second, different result of one of the rapid tests is mostly due to some instrumental or technical error as I had already told you earlier. Third, yes it is absolutely correct that the result of the HIV RNA test is claimed to be 100% accurate. Fourth, if your rapid tests are reactive than the HIV RNA viral load test will definitely be able to detect the presence of virus not only after 3 months even in earlier period by 3-4 weeks also. Fifth, as your CMIA test result is above 1 which might be suggestive of an early infection but it does not mean that the viral load test has to detect something because CMIA is less reliable and accurate than the viral load test result. Last but not the least I will say again yes the viral load test result is conclusive and you can trust it. So at the end again as your good friend I will advice you be ralxed and don't take so much of stress or tension. Go ahead in your life happily with a new commitment solely for your wife only. If still any questions left you can contact me again without any hesitation. Thank you very much
Above answer was peer-reviewed by :
Dr. Prasad
Dear Doctor...
Thank you for your comforting advice.
Based on the website i found, HIV RNA test may detect early infection 10 days post exposure. Is it true?
Some doctors says that HiV RNA test may detect as early as 4 days post exposure. Is it true?
Thanks again Doctor. This is seriously a life changing experience for me, and i really want to move ON. I am sorry for disturbing your precious time and really need your professional advice.
Why antibody tests such as CMIA, Immunochromatography and ELFA are less reliable compare to HIV-RNA test??
Can you help to advice on it?
Can i conclude that i should trust only the HiV-RNA test rather than other tests performed?
Thank you for your comforting advice.
Based on the website i found, HIV RNA test may detect early infection 10 days post exposure. Is it true?
Some doctors says that HiV RNA test may detect as early as 4 days post exposure. Is it true?
Thanks again Doctor. This is seriously a life changing experience for me, and i really want to move ON. I am sorry for disturbing your precious time and really need your professional advice.
Why antibody tests such as CMIA, Immunochromatography and ELFA are less reliable compare to HIV-RNA test??
Can you help to advice on it?
Can i conclude that i should trust only the HiV-RNA test rather than other tests performed?
Brief Answer:
Yes, HIV RNA test can detect early infection 10 days post exposure and true
Detailed Answer:
Dear XXX, yes it is true that HIV RNA test can detect early infection within 10 days post exposure or sometimes even earlier by one week also. First thing why CMIA or ELISA are less reliable than HIV RNA is that antibody tests are highly sensitive but somewhat less specific that is ability to distinguish HIV antibodies from other antibodies is slightly low. Another reason is if the person is in window period that is 6 weeks to 3 months than antibody tests are not able to detect the infection or they are false positive. So you have to trust HIV RNA test result more than any other tests performed as it is more accurate and reliable. Thank You
Yes, HIV RNA test can detect early infection 10 days post exposure and true
Detailed Answer:
Dear XXX, yes it is true that HIV RNA test can detect early infection within 10 days post exposure or sometimes even earlier by one week also. First thing why CMIA or ELISA are less reliable than HIV RNA is that antibody tests are highly sensitive but somewhat less specific that is ability to distinguish HIV antibodies from other antibodies is slightly low. Another reason is if the person is in window period that is 6 weeks to 3 months than antibody tests are not able to detect the infection or they are false positive. So you have to trust HIV RNA test result more than any other tests performed as it is more accurate and reliable. Thank You
Above answer was peer-reviewed by :
Dr. Shanthi.E
Dear Doctor...
Thank you for your detail explanation.
Does rapid tests, CMIA, Immunochromatography, and ELFA are the same? Or, each of them are different method?
Just of of curiousity, because my result on rapid tests are Non-Reactive. Does rapid tests method better than CMIA, Immunochromatography and ELFA to detect the HIV antibody test?
I feel so much relief and better after listen to your advice. I will try my best to move on and trust the viral load result. Thank you for your kind advice. I apologize for being paranoid, lost and fear in the last couple emails correspond.
Thank you for your detail explanation.
Does rapid tests, CMIA, Immunochromatography, and ELFA are the same? Or, each of them are different method?
Just of of curiousity, because my result on rapid tests are Non-Reactive. Does rapid tests method better than CMIA, Immunochromatography and ELFA to detect the HIV antibody test?
I feel so much relief and better after listen to your advice. I will try my best to move on and trust the viral load result. Thank you for your kind advice. I apologize for being paranoid, lost and fear in the last couple emails correspond.
Brief Answer:
Yes rapid tests, CMIA Immunochromatography and ELISA all are antibody tests
Detailed Answer:
Dear XXXX, yes rapid tests, CMIA, Immunochromatography and ELISA all are antibody detection tests but method is different for all of them. Rapid tests are much similar to other tests that you have mentioned not better than that. I will again say you can definitely trust the result of viral load test and move ahead in your life. I understand the anxiety that you have but rest reassured and don't take too much of stress. Thank you
Yes rapid tests, CMIA Immunochromatography and ELISA all are antibody tests
Detailed Answer:
Dear XXXX, yes rapid tests, CMIA, Immunochromatography and ELISA all are antibody detection tests but method is different for all of them. Rapid tests are much similar to other tests that you have mentioned not better than that. I will again say you can definitely trust the result of viral load test and move ahead in your life. I understand the anxiety that you have but rest reassured and don't take too much of stress. Thank you
Above answer was peer-reviewed by :
Dr. Shanthi.E
Brief Answer:
I am happy for your decision and you can trust the result of HIV RNA test.
Detailed Answer:
Dear XXXX, you are most welcome anytime. Yes you can definitely disregard the results of all antibody tests and trust the result of HIV RNA test. As it is negative you need not to paranoid or worried so much. Be relaxed and move on in your life leaving behind bad past that you had experienced. Thank you very much and wishing you very happy life ahead.
I am happy for your decision and you can trust the result of HIV RNA test.
Detailed Answer:
Dear XXXX, you are most welcome anytime. Yes you can definitely disregard the results of all antibody tests and trust the result of HIV RNA test. As it is negative you need not to paranoid or worried so much. Be relaxed and move on in your life leaving behind bad past that you had experienced. Thank you very much and wishing you very happy life ahead.
Above answer was peer-reviewed by :
Dr. Neel Kudchadkar
Dear Doctor...
My apology for writing you this email again. Believe me, i am trying to move on...but i can't really completely moved on.
I have a single question, hopefully it does not sound silly to you.
Why my antibody test on the 4th May (CMIA, Immunochromatography, ELFA) has different result with my rapid test kit on 11th May?
All test are to test the antibody, but why they are giving different result?
And, to confirm, the HIV-RNA test is to check the presence of the virus?
Thank you Doctor. Need your professional advice.
My apology for writing you this email again. Believe me, i am trying to move on...but i can't really completely moved on.
I have a single question, hopefully it does not sound silly to you.
Why my antibody test on the 4th May (CMIA, Immunochromatography, ELFA) has different result with my rapid test kit on 11th May?
All test are to test the antibody, but why they are giving different result?
And, to confirm, the HIV-RNA test is to check the presence of the virus?
Thank you Doctor. Need your professional advice.
Brief Answer:
It is due to technical or instrumental error and HIV RNA test detects virus
Detailed Answer:
Dear XXXX,
As I had already told you earlier different result of antibody tests is mostly due to technical or instrumental error nothing else and HIV RNA test is to detect the presence of virus antigen. Again I will say you need not to worry so much about this and move on in your life.
Thank you
It is due to technical or instrumental error and HIV RNA test detects virus
Detailed Answer:
Dear XXXX,
As I had already told you earlier different result of antibody tests is mostly due to technical or instrumental error nothing else and HIV RNA test is to detect the presence of virus antigen. Again I will say you need not to worry so much about this and move on in your life.
Thank you
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Dear Doctor...
Thank you for your response.
1. I have a anti-hepatitis A antibody. Will it have an effect in the CMIA, Immunochromatography and ELFA test?
2. My 1st lab stated in the report that for all "reactive" result, need to be confirm with RNA test. Is it common to have this kind of problem? Or, my case is one of a kind?
I am sorry for being very paranoid and fear. Never had this experience in my life before.
I even now scared to have an intimacy with my wife. Is it Ok to have intimacy with her?
Thank you Doctor....apology for disturbing your time.
Thank you for your response.
1. I have a anti-hepatitis A antibody. Will it have an effect in the CMIA, Immunochromatography and ELFA test?
2. My 1st lab stated in the report that for all "reactive" result, need to be confirm with RNA test. Is it common to have this kind of problem? Or, my case is one of a kind?
I am sorry for being very paranoid and fear. Never had this experience in my life before.
I even now scared to have an intimacy with my wife. Is it Ok to have intimacy with her?
Thank you Doctor....apology for disturbing your time.
Brief Answer:
Anti-hepatitis antibody has no effect on CMIA or ELISA or other rapid tests
Detailed Answer:
Dear XXXX, anti-hepatitis antibody has no effect on any test like CMIA or ELISA or Immunochromatography. As antibody tests are less reliable every positive result needs to be confirmed with RNA or any other confirmatory test. This kind of problem is quite common in others also not specifically in your case. Last but not the least you can have an intimacy with your wife so no need to worry for this. I will again advice you don't be paranoid or disturbed and move ahead in your life.
Anti-hepatitis antibody has no effect on CMIA or ELISA or other rapid tests
Detailed Answer:
Dear XXXX, anti-hepatitis antibody has no effect on any test like CMIA or ELISA or Immunochromatography. As antibody tests are less reliable every positive result needs to be confirmed with RNA or any other confirmatory test. This kind of problem is quite common in others also not specifically in your case. Last but not the least you can have an intimacy with your wife so no need to worry for this. I will again advice you don't be paranoid or disturbed and move ahead in your life.
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
Dear Doctor...
Thank you for your kind response.
I know that i shall trust the RNA result rather than my antibody test result.
It is just that my 1st antibody result (cmia,immunochromatography and ELSA) quite bothers me.
Since my 1st lab test (4th May 2015) and 2nd rapid test (11th May 2015) are detecting antibody test, if assuming the 1st lab result is correct, means the rapid test on the 4 kits used should pick the same reactive result?
Normally, for the CMIA, Immunochromatography and ELFA antibody test, are they using different kind of instrument for each test? Or, is it done using one single instrument??
I know i should move ON based on my RNA test result. Maybe my 1st result haunts me very bad.
Just assume the 1st test is correct, means the RNA test should pick up the presence of the virus, is it?
Need your advice again....and i am very sorry if i trouble your time...Thank you Doctor
Thank you Doctor. I will again try to forget the bad past and move on.
Thank you for your kind response.
I know that i shall trust the RNA result rather than my antibody test result.
It is just that my 1st antibody result (cmia,immunochromatography and ELSA) quite bothers me.
Since my 1st lab test (4th May 2015) and 2nd rapid test (11th May 2015) are detecting antibody test, if assuming the 1st lab result is correct, means the rapid test on the 4 kits used should pick the same reactive result?
Normally, for the CMIA, Immunochromatography and ELFA antibody test, are they using different kind of instrument for each test? Or, is it done using one single instrument??
I know i should move ON based on my RNA test result. Maybe my 1st result haunts me very bad.
Just assume the 1st test is correct, means the RNA test should pick up the presence of the virus, is it?
Need your advice again....and i am very sorry if i trouble your time...Thank you Doctor
Thank you Doctor. I will again try to forget the bad past and move on.
Brief Answer:
All tests that you have mentioned are done by using different instruments.
Detailed Answer:
Dear XXXX, I understand your situation very well. As I had already mentioned earlier if your first antibody test is reactive than it doesn't mean that rapid test should have to pick the same result also because antibody tests are less reliable specifically in earlier period post exposure. Second, all the tests that you have mentioned (CMIA, ELISA or Immunochromatography) are done using different instruments for each test. Again if you are assuming that if your first test result is correct than it doesn't mean the RNA test should have to pick up the presence of the virus. You can trust the result of HIV RNA test and move ahead in your life leaving behind bad past. Thank you very much
All tests that you have mentioned are done by using different instruments.
Detailed Answer:
Dear XXXX, I understand your situation very well. As I had already mentioned earlier if your first antibody test is reactive than it doesn't mean that rapid test should have to pick the same result also because antibody tests are less reliable specifically in earlier period post exposure. Second, all the tests that you have mentioned (CMIA, ELISA or Immunochromatography) are done using different instruments for each test. Again if you are assuming that if your first test result is correct than it doesn't mean the RNA test should have to pick up the presence of the virus. You can trust the result of HIV RNA test and move ahead in your life leaving behind bad past. Thank you very much
Above answer was peer-reviewed by :
Dr. Prasad
Dear Doctor....
To summarize: My last exposure is on 30th April 2015. My last HIV checked is on 26 August 2014.
1. I get confused because my 1st antibody test conducted on 4th May 2015 says reactive.
2. My 2nd antibody test using 4 different kits on 11th may 2015 running twice says that Non-Reactive on 3 instrument and 1 indeterminate.
3. My viral load test conducted on 11th May says that "No virus detected". And, my CD% is 33%
My questions are:
1. I am so confused because one of my antibody test says "Reactive" and the rapid test says "Non Reactive"
2. Can i say/conclude that the HIV RNA viraload test is to determine whether i have infected by the HIV virus?
3. Lets assume that i was infected after August 2014, why my 1st antibody test says "Reactive", and the rapid test says " Non Reactive"? I thought that antibody test should be able to pick up after 3 months period....
4. Lets assume that i was infected after August 2014, does the HIV-RNA will be able to tell the presence of the virus when i took the test on 11th May 2015?
I am not trying to put you in the hot seat or difficult position, Doctor. I am so stress, paranoid, lost, and fear. And this mixed feeling is not easy to digest for me right now. I need your professional advice on this.
Thank you very much Doctor.....really need your genuine advice.....i am sorry if i make you confused....
To summarize: My last exposure is on 30th April 2015. My last HIV checked is on 26 August 2014.
1. I get confused because my 1st antibody test conducted on 4th May 2015 says reactive.
2. My 2nd antibody test using 4 different kits on 11th may 2015 running twice says that Non-Reactive on 3 instrument and 1 indeterminate.
3. My viral load test conducted on 11th May says that "No virus detected". And, my CD% is 33%
My questions are:
1. I am so confused because one of my antibody test says "Reactive" and the rapid test says "Non Reactive"
2. Can i say/conclude that the HIV RNA viraload test is to determine whether i have infected by the HIV virus?
3. Lets assume that i was infected after August 2014, why my 1st antibody test says "Reactive", and the rapid test says " Non Reactive"? I thought that antibody test should be able to pick up after 3 months period....
4. Lets assume that i was infected after August 2014, does the HIV-RNA will be able to tell the presence of the virus when i took the test on 11th May 2015?
I am not trying to put you in the hot seat or difficult position, Doctor. I am so stress, paranoid, lost, and fear. And this mixed feeling is not easy to digest for me right now. I need your professional advice on this.
Thank you very much Doctor.....really need your genuine advice.....i am sorry if i make you confused....
Brief Answer:
No need to confuse ok and you can conclude with the result of HIV RNA test.
Detailed Answer:
Dear XXXX, I had already told you why two different antibody tests have different results so there is nothing to worry. Second, I had also told that you can conclude HIV RNA viral load test is to determine whether you are infected or not and your test result is negative so again there is nothing to worry. Third, yes antibody tests are more conclusive after 3 months and able to pick up the presence of antibody in 99% cases. Fourth, even if you was infected after august 2014, HIV RNA is able to detect the presence of virus in earlier period post exposure by 2 weeks or so. If still you are not satisfied I will advice for repeat HIV testing that will clear all your doubts. Thank you very much
No need to confuse ok and you can conclude with the result of HIV RNA test.
Detailed Answer:
Dear XXXX, I had already told you why two different antibody tests have different results so there is nothing to worry. Second, I had also told that you can conclude HIV RNA viral load test is to determine whether you are infected or not and your test result is negative so again there is nothing to worry. Third, yes antibody tests are more conclusive after 3 months and able to pick up the presence of antibody in 99% cases. Fourth, even if you was infected after august 2014, HIV RNA is able to detect the presence of virus in earlier period post exposure by 2 weeks or so. If still you are not satisfied I will advice for repeat HIV testing that will clear all your doubts. Thank you very much
Above answer was peer-reviewed by :
Dr. Shanthi.E
Dear Doctor XXXXXXX ...
Based on your assesment on my current test result, what is your medical professional advice on my situation?
Can i say that i am "clear" based on the HIV RNA result??
To confirm, after 3 months exposure, the HIV RNA test is able to detect the presence of the virus, is it?
To conclude, antigen (viraload) test is more accurate than antibody tests?
Thank you Doctor.....and i really want to move on with my life.....
Based on your assesment on my current test result, what is your medical professional advice on my situation?
Can i say that i am "clear" based on the HIV RNA result??
To confirm, after 3 months exposure, the HIV RNA test is able to detect the presence of the virus, is it?
To conclude, antigen (viraload) test is more accurate than antibody tests?
Thank you Doctor.....and i really want to move on with my life.....
Brief Answer:
Yes you are definitely clear on the basis of HIV RNA result and move ahead.
Detailed Answer:
Dear XXXX, on the basis of your current test results, I can definitely say that you can trust the result of HIV RNA test and you are absolutely clear. The HIV RNA test is able to detect the presence of the virus not after 3 months but even in earlier period post exposure. You can also conclude that antigen detection (viral load) test is more accurate than antibody detection tests. Again I am telling you as my friend just go ahead in life happily with your wife. Thank You
Yes you are definitely clear on the basis of HIV RNA result and move ahead.
Detailed Answer:
Dear XXXX, on the basis of your current test results, I can definitely say that you can trust the result of HIV RNA test and you are absolutely clear. The HIV RNA test is able to detect the presence of the virus not after 3 months but even in earlier period post exposure. You can also conclude that antigen detection (viral load) test is more accurate than antibody detection tests. Again I am telling you as my friend just go ahead in life happily with your wife. Thank You
Above answer was peer-reviewed by :
Dr. Prasad
Dear Doctor....
Thank you for sincere advise again. I really appreciate your kind and genuine answer.
I am just very bothered with my 1st antibody test result, because they using 3 kinds of instrument and all resulting "reactive"
I know i asked you this before, the antibody test result is no longer valid once i have my antigen result?
Thank you from the bottom of my heart....and thank you for willingly answering my redudant questions while i am so paranoid and lost my direction.
Thank you for sincere advise again. I really appreciate your kind and genuine answer.
I am just very bothered with my 1st antibody test result, because they using 3 kinds of instrument and all resulting "reactive"
I know i asked you this before, the antibody test result is no longer valid once i have my antigen result?
Thank you from the bottom of my heart....and thank you for willingly answering my redudant questions while i am so paranoid and lost my direction.
Brief Answer:
It is most probablydue to some technical or instrumental error nothing else
Detailed Answer:
Dear XXXX, you are thinking about your first result so much even though there is nothing to bother about that because your antigen detection test (HIV RNA viral load) is negative. The positive result is most probably due to some technical or instrumental error nothing else. You are most welcome my friend to ask for my help any time and I am here to do the same. Thank You
It is most probablydue to some technical or instrumental error nothing else
Detailed Answer:
Dear XXXX, you are thinking about your first result so much even though there is nothing to bother about that because your antigen detection test (HIV RNA viral load) is negative. The positive result is most probably due to some technical or instrumental error nothing else. You are most welcome my friend to ask for my help any time and I am here to do the same. Thank You
Above answer was peer-reviewed by :
Dr. Shanthi.E
Dear Doctor....
I know and realized that i should trust more on the RNA result as it really determine whether i am infected by the virus or not.
What haunts me is that i am just thinking that it is such a coincidence that 3 instruments are confirming the same "reactive" answer.
Back to my previous few threads, i did ask you this question. Just to have a final piece of mind.
1. I am just assuming that my 1st lab test is correct about the "Reactive" result, shall the HIV-RNA test be able to detect or confirm about the presence of the virus?? I am a little confused about this part. Can you help to explain to me?
2. Or, antibody amd antigen test are not related to one another?
3. Say that my antigen viraload is negative, and antibody result is reactive....can i say i am free from HIV??
Thank you doctor....hope this does not confuse you....as i am just thinking so much and try to put all the puzzle together....and this will be a very valuable learning experience for me too.....
I know and realized that i should trust more on the RNA result as it really determine whether i am infected by the virus or not.
What haunts me is that i am just thinking that it is such a coincidence that 3 instruments are confirming the same "reactive" answer.
Back to my previous few threads, i did ask you this question. Just to have a final piece of mind.
1. I am just assuming that my 1st lab test is correct about the "Reactive" result, shall the HIV-RNA test be able to detect or confirm about the presence of the virus?? I am a little confused about this part. Can you help to explain to me?
2. Or, antibody amd antigen test are not related to one another?
3. Say that my antigen viraload is negative, and antibody result is reactive....can i say i am free from HIV??
Thank you doctor....hope this does not confuse you....as i am just thinking so much and try to put all the puzzle together....and this will be a very valuable learning experience for me too.....
Brief Answer:
Yes antigen and antibody tests are not related to one another in the result
Detailed Answer:
Dear XXXX,
I am happy to listen that you have realized to trust more on the result of HIV RNA test.
First, usually if antibody test result is reactive (true positive) than HIV RNA test is definitely able to detect the presence of virus because it is much more accurate and conclusive than antibody test but still we can not relate them with each other in terms of re-activity as antibody tests are less reliable.
Second. your antibody test result is reactive in earlier period post exposure during which chance of giving false positive result is very high. At the same time antigen test is more reliable and able to detect the presence of virus. That is the reason I am repeatedly telling you to trust more on the result of HIV RNA test.
If still you are in any kind of confusion than go for repeat HIV testing with both antigen as well as antibody test. It will clear all your doubts and give you permanent sense of relief and happiness.
Thank you
Yes antigen and antibody tests are not related to one another in the result
Detailed Answer:
Dear XXXX,
I am happy to listen that you have realized to trust more on the result of HIV RNA test.
First, usually if antibody test result is reactive (true positive) than HIV RNA test is definitely able to detect the presence of virus because it is much more accurate and conclusive than antibody test but still we can not relate them with each other in terms of re-activity as antibody tests are less reliable.
Second. your antibody test result is reactive in earlier period post exposure during which chance of giving false positive result is very high. At the same time antigen test is more reliable and able to detect the presence of virus. That is the reason I am repeatedly telling you to trust more on the result of HIV RNA test.
If still you are in any kind of confusion than go for repeat HIV testing with both antigen as well as antibody test. It will clear all your doubts and give you permanent sense of relief and happiness.
Thank you
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Dear Doctor XXXXXXX ...
Thank you again for your advice. Understood from your explanation that i should move on with my life and leave the bad experience behind.
Pleasr correct me of my summary:
1. I should trust and worried more about the HIV-RNA result compare to antibody tests??
2. If the 1st test is a true positive, then HIV-RNA should be able to confirm it?
3. Based on my case, does it means the rapid test result is correct??
4. Shall i worry about my CD4% of 33% and CD count of 364??
Thank you once again. If you have any other things to share with me aside from my questions regarding my situation, please do not hesitate to share with me. I will move on and be a better man in life.
Thank you again for your advice. Understood from your explanation that i should move on with my life and leave the bad experience behind.
Pleasr correct me of my summary:
1. I should trust and worried more about the HIV-RNA result compare to antibody tests??
2. If the 1st test is a true positive, then HIV-RNA should be able to confirm it?
3. Based on my case, does it means the rapid test result is correct??
4. Shall i worry about my CD4% of 33% and CD count of 364??
Thank you once again. If you have any other things to share with me aside from my questions regarding my situation, please do not hesitate to share with me. I will move on and be a better man in life.
Brief Answer:
The answer for your first three queries is yes and for last query it is no.
Detailed Answer:
Dear XXXXX, first of all I really appreciate your positive attitude now. As per your summary I will say yes, you have to trust and worried more regarding HIV RNA test result and it is able to detect the presence of virus if antibody test gives true positive result. In your case I can say rapid test result is correct because HIV RNA viral load test result is also negative. Lastly, you need not to worry about your CD4 count as it is good enough at present but too much of stress can reduce it so you have to relax and move ahead in your life. In the end I will say just forget your bad past experience and enjoy happily with your wife. Thank You
The answer for your first three queries is yes and for last query it is no.
Detailed Answer:
Dear XXXXX, first of all I really appreciate your positive attitude now. As per your summary I will say yes, you have to trust and worried more regarding HIV RNA test result and it is able to detect the presence of virus if antibody test gives true positive result. In your case I can say rapid test result is correct because HIV RNA viral load test result is also negative. Lastly, you need not to worry about your CD4 count as it is good enough at present but too much of stress can reduce it so you have to relax and move ahead in your life. In the end I will say just forget your bad past experience and enjoy happily with your wife. Thank You
Above answer was peer-reviewed by :
Dr. Prasad
Dear Doctor....
Thank you for all the confirmation answer.
I have one last question and hope this will be the last.
In between 26 August 2014 to 30th April 2015, i have fews protected intercouse. My last exposure is on 30th April 2015.
Is it going to effect my RNA result or antibody test? I need your advice on this. Or, my last RNA test on 11th May 2015 is conclusive?
Is there any period of time or certain limitation that RNA viraload cannot detect the virus? For example, if i exposed over 1 year, does the RNA test still be able to detect the presence of the virus?
Correct me if i am wrong, the RNA test is to detect the virus in my bloodstream and body, is it??
Thank you, Doctor....thank you for helping me with your medical advice experience....
Thank you.....
Thank you for all the confirmation answer.
I have one last question and hope this will be the last.
In between 26 August 2014 to 30th April 2015, i have fews protected intercouse. My last exposure is on 30th April 2015.
Is it going to effect my RNA result or antibody test? I need your advice on this. Or, my last RNA test on 11th May 2015 is conclusive?
Is there any period of time or certain limitation that RNA viraload cannot detect the virus? For example, if i exposed over 1 year, does the RNA test still be able to detect the presence of the virus?
Correct me if i am wrong, the RNA test is to detect the virus in my bloodstream and body, is it??
Thank you, Doctor....thank you for helping me with your medical advice experience....
Thank you.....
Brief Answer:
No intercourse is not going to effect RNA test result and it is conclusive.
Detailed Answer:
Dear XXXX, you had done few protected intercourse and it is not going to effect your HIV RNA or antibody test result. You can consider your last HIV RNA test as conclusive. As per another query, HIV RNA viral load can detect the presence of virus any time after 2 weeks post exposure. Yes, HIV RNA test is to detect the virus in your blood stream. Wishing you happy and healthy life ahead. Thank you
No intercourse is not going to effect RNA test result and it is conclusive.
Detailed Answer:
Dear XXXX, you had done few protected intercourse and it is not going to effect your HIV RNA or antibody test result. You can consider your last HIV RNA test as conclusive. As per another query, HIV RNA viral load can detect the presence of virus any time after 2 weeks post exposure. Yes, HIV RNA test is to detect the virus in your blood stream. Wishing you happy and healthy life ahead. Thank you
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
Dear Doctor...
Thank you again for your kind answers to all my questions.
In the previous thread, you mentioned that during early post exposure, the chance of antibody test giving false positive is very high? May i know what is the cause/reason??
Thank you again for all the well wishes. I will try very hard to move on with my life.
Thank you from the bottom of my heart for going thru this though phases with me.
Thank you again for your kind answers to all my questions.
In the previous thread, you mentioned that during early post exposure, the chance of antibody test giving false positive is very high? May i know what is the cause/reason??
Thank you again for all the well wishes. I will try very hard to move on with my life.
Thank you from the bottom of my heart for going thru this though phases with me.
Brief Answer:
It is just because antibodies will take variable time to appear in blood.
Detailed Answer:
Dear XXXXX, antibodies would appear in the blood by 6-8 weeks in the presence of infection or may be delayed up to three months. So during early post exposure period it might happen that antibody test will give very high false positive result. This is the reason why antibody tests are considered less reliable in the earlier period post exposure. Thank you very much and you are most welcome.
It is just because antibodies will take variable time to appear in blood.
Detailed Answer:
Dear XXXXX, antibodies would appear in the blood by 6-8 weeks in the presence of infection or may be delayed up to three months. So during early post exposure period it might happen that antibody test will give very high false positive result. This is the reason why antibody tests are considered less reliable in the earlier period post exposure. Thank you very much and you are most welcome.
Above answer was peer-reviewed by :
Dr. Shanthi.E
Thank you doctor for your kind explanation.
Everything now seems to be clear.
I am still thinking about my 1st antibody test. But, like you said, if the 1st antibody test is true positive then my viraload test will give a positive result as well.
For now, i shall move on and trust the RNA test as it is directly check the presence of the virus itself.
Thank you again Doctor. If anything you have in mind to add to my situation, please do so. Your advice is greatly appreciated.
Everything now seems to be clear.
I am still thinking about my 1st antibody test. But, like you said, if the 1st antibody test is true positive then my viraload test will give a positive result as well.
For now, i shall move on and trust the RNA test as it is directly check the presence of the virus itself.
Thank you again Doctor. If anything you have in mind to add to my situation, please do so. Your advice is greatly appreciated.
Brief Answer:
No nothing to say much just keep it up and move ahead in your life happily.
Detailed Answer:
Dear XXXXX, I am really happy as you are looking much more relaxed and less worried now. Nothing much to say more just trust the result of HIV RNA test and move ahead in life with your wife happily and be completely faithful to her only. Thank you very much and most welcome any time when you need me.
No nothing to say much just keep it up and move ahead in your life happily.
Detailed Answer:
Dear XXXXX, I am really happy as you are looking much more relaxed and less worried now. Nothing much to say more just trust the result of HIV RNA test and move ahead in life with your wife happily and be completely faithful to her only. Thank you very much and most welcome any time when you need me.
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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