Question: Hi, my wife is a 28 year old type 1 diabetic. 114 pounds, 5'3. I feel it is important for you to have some background information to have a better overall picture here. She had high cholesterol, LDL was 220 (HDL 90, triglycerides normal) when we checked it about a year and a half ago (The dr also said in his charts he saw it was this high quite a few years back too so we can assume it was always about this high) and she was prescribed statins. She was diagnosed with a not so common liver disorder by a gastroenterologist, they recently coined a term for this so no one has heard of it, diabetic hepatosclerosis. Her gastroenterologist said she could still get pregnant, he did not expect this to effect her for decades. She was removed from statins due to her liver condition and was prescribed Welchol. This has lowered her LDL to 155. However, her endocrinologist told her she must come off of Welchol due to this not having any human pregnancy studies. My concern is her increased risk of heart disease for the one year that she would need to stop taking this medication. So, my question is what is the increase in risk for a 60 point increase in LDL for one year? It seems logical to me to not even consider getting pregnant, and in fact to consider reducing her cholesterol even further. What is your advice?

Thank you for your answer. How does stopping treatment for one year effect her long term risk, taking into account that her cholesterol would be about 200 LDL (HDL 90, triglycerides normal ) for that year without the medication? If there is no way for you to judge her long term risk from this that's okay, just curious if perhaps you were able to determine this based on these numbers.

Thanks again,
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