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Is It Safe To Take Contrave Before Amitriptyline HCI 75mg?

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Posted on Fri, 5 Jun 2020
Twitter Fri, 5 Jun 2020 Answered on
Twitter Fri, 26 Sep 2025 Last reviewed on
Question : Is it safe to take Contrave before Amitriptyline HCI 75mg, Benadryl, and melatonin over the counter?
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Answered by Dr. AJEET SINGH (45 minutes later)
Brief Answer:
They should always be taken under medical supervision.

Detailed Answer:
Hi ,

I have gone through your query and here is my opinion.

Kindly share your symptomatology in detail and let me know,for what all indications are you going to take these drugs?
Is it for improving the quality of sleep?

Contrave is a combination of naltrexone HCI, which is commonly used to treat substance abuse and bupropion HCI is an antidepressant ,also used for smoking cessation.
Contrave is FDA approved for weight loss and is clinically used for it.
Melatonin alone or in combination with amitriptyline are used to reduce pain and to improve sleep cycle.

No clinically significant interactions have been found between Benadryl Amitriptyline,contrave and melatonin but these drugs should always be taken under the medical supervision of a qualified clinician.

Waiting for your revert.

Best regards.
Above answer was peer-reviewed by : Dr. Nagamani Ng
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Answered by
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Dr. AJEET SINGH

General & Family Physician

Practicing since :1994

Answered : 2144 Questions

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Is It Safe To Take Contrave Before Amitriptyline HCI 75mg?

Brief Answer: They should always be taken under medical supervision. Detailed Answer: Hi , I have gone through your query and here is my opinion. Kindly share your symptomatology in detail and let me know,for what all indications are you going to take these drugs? Is it for improving the quality of sleep? Contrave is a combination of naltrexone HCI, which is commonly used to treat substance abuse and bupropion HCI is an antidepressant ,also used for smoking cessation. Contrave is FDA approved for weight loss and is clinically used for it. Melatonin alone or in combination with amitriptyline are used to reduce pain and to improve sleep cycle. No clinically significant interactions have been found between Benadryl Amitriptyline,contrave and melatonin but these drugs should always be taken under the medical supervision of a qualified clinician. Waiting for your revert. Best regards.