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Is Pregnancy Miscarriage Possible Due To Hypothyroidism And Unstable TSH?

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Posted on Tue, 29 Oct 2024
Question: My wife is 23 years old suffering from hypothyroidism approximately 5 years ago. She was on 50 MCG levothyroxine. However, Her TSH Test was showing 22 mU/L on April 25, 2022 so her doctor prescribed 125 MCG dose to help maintain the hormone. On May 28, 2022 she was tested for pregnancy but the result was negative. On XXXXXXX 6, 2022 , Her TSH was 0.18 mU/L so her doctor advised to lower the dose to 100 MCG. However, on XXXXXXX 11, 2022 the pregnancy test was positive and UT report was suggesting gestational sac confirming early stage pregnancy. Is pregnancy miscarriage possible due to hypothyroidism and unstable TSH? What can be done currently to avoid miscarriage?
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Answered by Dr. Satnarain Bansal (14 hours later)
Brief Answer:
As below

Detailed Answer:
In my opinion,titration of your dose of levothyroxine was not proper.Were you tested for T3 & T4 levels also. If these were normal, then even with increased TSH, the increase in dose should have been mild say upto 75 microgram.I am still of the opinion that this dose should be 75 microgram even now & it should be adjusted every fortnight according to readings of T3,T4 &TSH levels till reading is stabilised. After this the time interval between testing can be gradually increased.
Definitely,disturbed level of thyroid hormone can increase chances of miscarriage. However,your sonography report seems normal.
Still, you are advised to take treatment under guidance of your doctor,particularly in reference to your thyroid levels to minimise the chances of miscarriage etc.
Thanks.
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.
Above answer was peer-reviewed by : Dr. LAKSHMI
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Answered by
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Dr. Satnarain Bansal

General & Family Physician

Practicing since :1975

Answered : 1502 Questions

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Is Pregnancy Miscarriage Possible Due To Hypothyroidism And Unstable TSH?

Brief Answer: As below Detailed Answer: In my opinion,titration of your dose of levothyroxine was not proper.Were you tested for T3 & T4 levels also. If these were normal, then even with increased TSH, the increase in dose should have been mild say upto 75 microgram.I am still of the opinion that this dose should be 75 microgram even now & it should be adjusted every fortnight according to readings of T3,T4 &TSH levels till reading is stabilised. After this the time interval between testing can be gradually increased. Definitely,disturbed level of thyroid hormone can increase chances of miscarriage. However,your sonography report seems normal. Still, you are advised to take treatment under guidance of your doctor,particularly in reference to your thyroid levels to minimise the chances of miscarriage etc. Thanks.