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Is Smoking Marijuana Advisable While On Fluconazole?

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Posted on Wed, 26 Jul 2017
Twitter Wed, 26 Jul 2017 Answered on
Twitter Wed, 23 Aug 2017 Last reviewed on
Question : Hi, what happens if I smoke marijuana while on Fluconozole. Is it okay to do?

Thanks.
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Answered by Dr. V. N. S. Parinam (19 minutes later)
Brief Answer:
No

Detailed Answer:
Hi,

It is not good to use Marijuana and Fluconazole at the same time. Fluconazole is a CYP2C9 inhibitor. Marijuana is metabolized by CYP2C9 pathway. So if you take both of them, Fluconazole will try to reduce the Marijuana metabolism and thereby increases its concentration by many fold.

You will have adverse effects and toxicity associated with Marijuana.

Hope this understanabale.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. V. N. S. Parinam

General & Family Physician

Practicing since :2008

Answered : 1727 Questions

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Is Smoking Marijuana Advisable While On Fluconazole?

Brief Answer: No Detailed Answer: Hi, It is not good to use Marijuana and Fluconazole at the same time. Fluconazole is a CYP2C9 inhibitor. Marijuana is metabolized by CYP2C9 pathway. So if you take both of them, Fluconazole will try to reduce the Marijuana metabolism and thereby increases its concentration by many fold. You will have adverse effects and toxicity associated with Marijuana. Hope this understanabale.