Brief Answer:
It can be withheld on weekends after discussion with physician

Detailed Answer:
Hi

Thanks for asking on Ask A Doctor platform

I have gone through the query and do understand your.
Ritalin LA contains methylphenidate and it is a long acting formulation.
The time of onset of action is about 1 hours and half life of elimination of drug from body is about 10 hours.
There are many studies showing the drug holiday means discontinuing the medicine on weekend has some benefits but still this is not followed as a recommendation. Considering the less duration for onset of action weekend gap should not effect the next dose.
As the onset of action is less the drug holiday can be considered after discussion with the treating physician under close monitoring.

I hope this helps.
Please let me know if you have any more questions.
Regards

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Brief Answer:
Yes

Detailed Answer:
Yes, because of short duration of onset of action and limited half life of elimination from body. But drug holiday should be strictly under supervision of physician.
Regards

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