Reports Show Renal Aterry Stenosis, Mild Hypertrophy Septum And Total Cholesterol 187. Suggestions

Posted on Sat, 30 Nov 2013

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Fri, 29 Nov 2013 Answered on

Mon, 23 Dec 2013 Last reviewed on

Question : i am suffering from uncontrolled hypertension for the past 3 mths previously i would have had hypertension for the past 20 years . I am 50 years old. For the first 12 years i used Atenonol 50mg once per day. The other 8 years i used Vaserectic 10/25mg and atenonol 50mg once a day. these worked well until the last 3 months. I have tried aldomet 500mg , lisinopril 10mg , twice a day and atenonol 50mg once a day. this controls it to around 145/95 at its best but rises at night and by morning the diastolic is 100 - 105. Doctor has also tried Exforge 5mg / 320mg but this is not working at all , The result is i have gone back to the previous combination of aldomet , lisinopril and atenonol. i was hospitalised recently and a number of tests were done . Results are attached for your attention and consideration, Could you recommend medications that can solve my problem. Please note i have a family history of hypertension where uncles and aunts have died of stroke or heart attack. An ultrasound of kidney shows no sonographic evidence of renal aterry stenosis. An echocardiogram report shows very mild hypertrophy septum. Also very mild dialated left atrium. Blood lab results shows total cholesterol 187, LDL 112 and HDL 42. Triglyceride 168

Answered by Dr. Jorge Brenes-Salazar (-28 minutes later)

Brief Answer: Consider alternative combinations Detailed Answer: Dear patient, Thanks for the query. Your goal blood pressure must be less than 140/90 most of the time. Instead of atenolol, which is probably the least potent of the beta blockers, I would strongly suggest changing that to carvedilol, which is also a beta blocker but also blocks alpha receptors and then tends to have a more potent anti-hypertensive effect; the second change that I would make would be switching the Aldomet for a good reliable diuretic, such as chlorthalidone; the main side effect of this diuretic is lowering potassium, but in your case that would be neutralized by the lisinopril 20 mg daily. I would allow 1 month on those 3 medications, titrated every 2 weeks until XXXXXXX dose, before adding any other agent. Both carvedilol and chlorthalidone are available for about $4 per month as good quality generics. Hope that helps, wish you the best, Dr Brenes-Salazar MD Mayo Clinic MN Cardiology

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Jorge Brenes-Salazar (6 hours later)

Hi thanks for your reply. I have uploaded some reports or your consideration. Also included in my medication is aprinox 2.5mg. so my daily medication consist of atenonol 50 mg once daily lisinopril 20 mg once daily aldomet 500mg twice daily aprinox 2.5mg once daily please advise on your daily dosage of your medication taking into consideration my blood pressure rises in the evening and night-time. Can any medication be given to assist with the changes of the heart caused by the hypertension Thanks or your consideration

Answered by Dr. Jorge Brenes-Salazar (15 hours later)

Brief Answer: Review of doses Detailed Answer: Thanks for the follow up. Given the fact that you already are on a diuretic (aprinox), it would not make much sense to add chlorthalidone then. Thus, the regimen that would be reasonable given your medications is the following: lisinopril same dose, aprinox same dose, switch aldomet to a calcium channel blocker such as amlodipine, starting dose 5 mg, and the the atenolol would be switched to carvedilol, usual starting dose is 6.25 mg BID. Please discuss this "combo" with your provider. Yours truly Dr Brenes-Salazar MD

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar