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Resistance To VIROPIL Is Very Much Likely To Happen
Question: Respected doctor...today accidentally one occupational exposure happend doctor ..after With in 10 hour i started PEP(Viropil)...But i feared onething doctor..Past 3 years back same medicine i taken 2 to 3 times for the same exposure..after 3 years today i taken...anything resistance came doctor?That mean reduced some efficacy??or if reduced efficacy means can i canged combination of drug doctor??..Kindly response doctor..
Brief Answer:
Resistance to VIROPIL is very much unlikely
Detailed Answer:
Hi,
Welcome to ASK A DOCTOR through HCM.
Thanks for posting your query.
There is no clearcut guidelines about the use of frequent PEP leads to resistance and becomes ineffective.
I would like to know more about your previous PEP, Whether it was the same with Viropil or with any other drugs before 3 years?
Viropil, which contains the INSTI drug Douletegravir has a high 'genetic barrier' and less likely to develop resistance like other ART dugs. Especially the NNRTI drugs are able to develop resistance earlier which were included in PEP during the yester years.
So, it is very much unlikely to develop resistance to Viropil. Not to worry. Anyhow follow the PEP protocol strictly. (strict adherence to drug, Tests for HIV antibodies on day 0, 1 month, 3 months and 6 months.
Thanks.
Dr S. Murugan
Resistance to VIROPIL is very much unlikely
Detailed Answer:
Hi,
Welcome to ASK A DOCTOR through HCM.
Thanks for posting your query.
There is no clearcut guidelines about the use of frequent PEP leads to resistance and becomes ineffective.
I would like to know more about your previous PEP, Whether it was the same with Viropil or with any other drugs before 3 years?
Viropil, which contains the INSTI drug Douletegravir has a high 'genetic barrier' and less likely to develop resistance like other ART dugs. Especially the NNRTI drugs are able to develop resistance earlier which were included in PEP during the yester years.
So, it is very much unlikely to develop resistance to Viropil. Not to worry. Anyhow follow the PEP protocol strictly. (strict adherence to drug, Tests for HIV antibodies on day 0, 1 month, 3 months and 6 months.
Thanks.
Dr S. Murugan
Above answer was peer-reviewed by :
Dr. Kampana
Day 0 hiv 4th gen test is negative sir..3 years before 2 to 3 times i taken viropil sir...After yesterday i started sir..same drug viropil.
Brief Answer:
Your PEP will be effective 100%
Detailed Answer:
Hi,
Welcome back.
Resistance to Viropil is extremely rare.
Imagine that you had taken Viropil thrice previously, That too three years back. Assume these previous exposures exposures were noninfectious episodes (really they were not having any viral particles), then there is no question of viral resistance to ART. Moreover, this time with this present exposure your are not getting any resistant strain at all, if at all that exposure was an infectious one. So once again there is no question of resistance to drugs. Presently your 4th generation HIV test was nonreactive. So you don't have any virus inside your body already. So there is no risk for Drug resistance.
So not to worry. The PEP will be effective 100%.
Dr S. Murugan
Your PEP will be effective 100%
Detailed Answer:
Hi,
Welcome back.
Resistance to Viropil is extremely rare.
Imagine that you had taken Viropil thrice previously, That too three years back. Assume these previous exposures exposures were noninfectious episodes (really they were not having any viral particles), then there is no question of viral resistance to ART. Moreover, this time with this present exposure your are not getting any resistant strain at all, if at all that exposure was an infectious one. So once again there is no question of resistance to drugs. Presently your 4th generation HIV test was nonreactive. So you don't have any virus inside your body already. So there is no risk for Drug resistance.
So not to worry. The PEP will be effective 100%.
Dr S. Murugan
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Thank you so much doctor..after PEP...60 days after can i take repeat that hov test doctor?
Brief Answer:
The HIV antibody test conclusive after 6 months
Detailed Answer:
Hi,
Welcome back
In any normal situations, the HIV antibody detection test 90 days after the exposure will be conclusive. But as you have taken PEP, the antibody formation (if any) can be delayed up to 6 months. So, in your case the outcome of the antibody test can be considerd confirmative and conclusive 6 months after the exposure.
But PEP taken within 72 hours, (that too within 10 hours as in your case) is a foolproof way to abort the disease if any. Not to worry.
Dr S. Murugan
The HIV antibody test conclusive after 6 months
Detailed Answer:
Hi,
Welcome back
In any normal situations, the HIV antibody detection test 90 days after the exposure will be conclusive. But as you have taken PEP, the antibody formation (if any) can be delayed up to 6 months. So, in your case the outcome of the antibody test can be considerd confirmative and conclusive 6 months after the exposure.
But PEP taken within 72 hours, (that too within 10 hours as in your case) is a foolproof way to abort the disease if any. Not to worry.
Dr S. Murugan
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Thank you so much doctor..2nd day finished sir...vomiting sensation is there sir....otherwise ok sir
Brief Answer:
It will not affect your diabetic status and not the kidney functions
Detailed Answer:
Hi,
Welcome back.
People are living with daily Viropil for years without any problem. It will not precipitate your pre-diabetic state (Not mentioned the recent blood sugar level (fasting and Postprandial).
If you are already having kidney disease and bad renal function tests, Viropil may worsen the condition. In a normal individual, it will not have any such effect, that too with a PEP (short course). Not to worry at all.
Dr S. Murugan
It will not affect your diabetic status and not the kidney functions
Detailed Answer:
Hi,
Welcome back.
People are living with daily Viropil for years without any problem. It will not precipitate your pre-diabetic state (Not mentioned the recent blood sugar level (fasting and Postprandial).
If you are already having kidney disease and bad renal function tests, Viropil may worsen the condition. In a normal individual, it will not have any such effect, that too with a PEP (short course). Not to worry at all.
Dr S. Murugan
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Above answer was peer-reviewed by :
Dr. Vaishalee Punj
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