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Suggest Alternative Medication After Chemotherapy Xeloda And Irinotecan Have Failed
Question: What can
Be done if chemotherpay xeloda and irinotecan has not worked? Bowel cancer operation was march 2014. A further met has appeared while on irinotecan .
Be done if chemotherpay xeloda and irinotecan has not worked? Bowel cancer operation was march 2014. A further met has appeared while on irinotecan .
Brief Answer:
ZALTRAP
Detailed Answer:
Hi
Since a further mets have developed with xeloda and irinotecan in a case of bowel cancer i will now recommend to use the new drug ZALTRAP also called ziv-aflibercept.
Tumors depend on new blood vessels to grow. Without these blood vessels providing nutrients and oxygen, the cancer cells cannot grow. The VEGF (Vascular Endothelial Growth Factor) family contributes to the growth of new blood vessels.
ZALTRAP works by binding to VEGF family members VEGF-A, VEGF-B, and PLGF, which may help to block the growth of new blood vessels. This includes normal blood vessels as well as blood vessels that supply tumors.
Major side effects of this drug are low white blood cell count, diarrhea, too much protein in the urine ,increased blood pressure, decreased appetite, low blood platelet count and increased blood pressure.
You can disuss the drug with your treating physician.
Regards
DR DE
ZALTRAP
Detailed Answer:
Hi
Since a further mets have developed with xeloda and irinotecan in a case of bowel cancer i will now recommend to use the new drug ZALTRAP also called ziv-aflibercept.
Tumors depend on new blood vessels to grow. Without these blood vessels providing nutrients and oxygen, the cancer cells cannot grow. The VEGF (Vascular Endothelial Growth Factor) family contributes to the growth of new blood vessels.
ZALTRAP works by binding to VEGF family members VEGF-A, VEGF-B, and PLGF, which may help to block the growth of new blood vessels. This includes normal blood vessels as well as blood vessels that supply tumors.
Major side effects of this drug are low white blood cell count, diarrhea, too much protein in the urine ,increased blood pressure, decreased appetite, low blood platelet count and increased blood pressure.
You can disuss the drug with your treating physician.
Regards
DR DE
Above answer was peer-reviewed by :
Dr. Ashwin Bhandari
They said he can't have more chemo as his cancer prob resistant to it . Is this true ?
They said we can't do nothing . Isn't their approach wrong ?
The mets are as
Liver met small
1 node small
1 sub pleural nodule small
Can these be ablated ?
They said we can't do nothing . Isn't their approach wrong ?
The mets are as
Liver met small
1 node small
1 sub pleural nodule small
Can these be ablated ?
Brief Answer:
Ablation
Detailed Answer:
Hi
The metastasis are small in size.
Since chemotherapy is not working these can be easily ablated.
Regards
DR DE
Ablation
Detailed Answer:
Hi
The metastasis are small in size.
Since chemotherapy is not working these can be easily ablated.
Regards
DR DE
Above answer was peer-reviewed by :
Dr. Raju A.T
Ok thx . We are considering nano knife . Can anything be done to control the micro mets ?
Does 2 failures mean all chemo will not work ?
Will this now effect survival time ?
Does 2 failures mean all chemo will not work ?
Will this now effect survival time ?
Brief Answer:
Regorafenib
Detailed Answer:
Hi
Yes nano knife is a good option.
To control the micro mets Regorafenib oral tablets can be taken. Discuss the drug with your treating physician.
2 failures does not mean all chemotherapy will not work.
Third line of chemotherapy can be tried.
Average survival time is around 2 years.
Regards
DR DE
Regorafenib
Detailed Answer:
Hi
Yes nano knife is a good option.
To control the micro mets Regorafenib oral tablets can be taken. Discuss the drug with your treating physician.
2 failures does not mean all chemotherapy will not work.
Third line of chemotherapy can be tried.
Average survival time is around 2 years.
Regards
DR DE
Above answer was peer-reviewed by :
Dr. Yogesh D
If mets are small and few and we do nano knife few times can survival b more even ? 2 years is for those with very extensive mets right ?
Brief Answer:
survival will be more than 2 years
Detailed Answer:
Hi
Yes as the metastsis is small in size and are few in number if you do ablation survival will be more than 2 years.
After ablation Regorafenib tablets which are oral chemotherapy tablets needs to be taken to prevent the metastasis from coming back.
Regards
DR DE
survival will be more than 2 years
Detailed Answer:
Hi
Yes as the metastsis is small in size and are few in number if you do ablation survival will be more than 2 years.
After ablation Regorafenib tablets which are oral chemotherapy tablets needs to be taken to prevent the metastasis from coming back.
Regards
DR DE
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Thank you so much for your help in this difficult time . Will def ask for the tablets , but can the tabs cause heart attack ?
Brief Answer:
It will not cause heart attack
Detailed Answer:
Hi
Side effects of Regorafenib are fever or chills, rash and headache.
The tablets will not cause hear attack.
It may cause slow or fast heartbeats so you can do 2D echocardiography test to see the condition of the heart before starting the drug.
If you have no more clarifications then please rate the answer and close the thread.
Regards
DR DE
It will not cause heart attack
Detailed Answer:
Hi
Side effects of Regorafenib are fever or chills, rash and headache.
The tablets will not cause hear attack.
It may cause slow or fast heartbeats so you can do 2D echocardiography test to see the condition of the heart before starting the drug.
If you have no more clarifications then please rate the answer and close the thread.
Regards
DR DE
Note: For further queries related to kidney problems Click here.
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
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