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Suggest Medication For Schizophrenia

Posted on Fri, 3 Nov 2017

Question: i like to know whats mean effect size for a drug for shizophrenia? its different factor for effecteveness?

Answered by Dr. Seikhoo Bishnoi (38 minutes later)

Brief Answer:
Effect size compare efficacy between two modalities.

Detailed Answer:
Hello thanks for asking from HCM

Effect size is a statistical calculation that is done in order to compare efficacy of treatment between two drugs by quantifying size of difference between the treatments.

If two drugs used for Schizophrenia are compared in terms of efficacy then effect size can be used. This is a dimensionless calculation.

Effectiveness is the degree of desired effects of a drug. This is not a comparative value. If effectiveness is compared then that will be compared with Effect size.

Thanks and Take care

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Seikhoo Bishnoi (14 minutes later)

i have a link for all effectness drug at lancet? but i like to know the similar for new drug vraylar(cariprazine). i go to google but not undertand the statictics and medical language.
the link below:
http://www.yyyyyt.com/yyyyyyyy/lyyyyt/ayyyye/ooS0000-0000(13)00000-3/fulltext

Answered by Dr. Seikhoo Bishnoi (8 hours later)

Brief Answer:
Cariprazine showed greater efficacy in negative symptoms.

Detailed Answer:
Hello thanks for asking again

The particular study you mentioned didn't include Cariprazine. As the drug is new drug so the studies on it are limited.

In one study about 460 patients were included and 230 received Cariprazine and 230 received Risperidone. The study compared efficacy and side effects of Cariprazine with Risperidone. The Cariprazine group showed greater improvement in negative symptoms compared to Risperidone group. The effect size in that particular study was 0.31. The difference was statistically significant.

Thanks

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Seikhoo Bishnoi (7 hours later)

what do u think dr how much the improvement on negative symptoms on this drug like alogia, amotivation, anhedonia..

Answered by Dr. Seikhoo Bishnoi (5 hours later)

Brief Answer:
You can expect improvement of around 40%

Detailed Answer:
Hello thanks for asking again

Though I haven't used this drug but as per studies the drug has great efficacy in controlling the negative symptoms. But you can expect improvement of around 40% with this drug. Though more detailed studies on this drug are still undergoing.

Thanks

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar