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Suggest Treatment For Endometrial Cancer
Question: Hi Dr XXXX,
My name is XXXX I had a Total Knee Replacement one year ago. It turns out that I am allergic to Titanium, Zirconium and Iron. The prosthesis is still inside me since the new one has not arrived yet (or so I am being told by the orthopedist). Last week, I was told I have High grade malignancy, consistent with undifferentiated endometrial carcinoma. I believe my cancer is caused by the allergies to the above metal in my prosthesis which has been inside me for too long. How can I prove it ? Is there any study to that effect that I can print and convince my Government so it does not happen to anyone else.
My name is XXXX I had a Total Knee Replacement one year ago. It turns out that I am allergic to Titanium, Zirconium and Iron. The prosthesis is still inside me since the new one has not arrived yet (or so I am being told by the orthopedist). Last week, I was told I have High grade malignancy, consistent with undifferentiated endometrial carcinoma. I believe my cancer is caused by the allergies to the above metal in my prosthesis which has been inside me for too long. How can I prove it ? Is there any study to that effect that I can print and convince my Government so it does not happen to anyone else.
Brief Answer:
Allergies can not cause endometrial cancer.
Detailed Answer:
Hello dear, thanks for your question on HCM.
I can understand your situation and problem.
Endometrial carcinoma is not caused by any allergy. There is no literature supporting this association.
Old age is the risk factor for endometrial carcinoma. And at your age of 62 years, chances are high.
Other probable causes are
1. Nulliparity
2. High estrogen levels
3. Delayed menopause
4. Smoking
5. Associated breast or colon cancer etc.
It is having many causes as mentioned above and no literature mentioned about allergies as a cause.
So in your case, it is not possible to prove that allergies is the cause for your endometrial carcinoma because no literature or study is available to support it and your age (62 years) can be the risk factor for endometrial carcinoma.
Hope I have solved your query.
I will be happy to help you further.
Wish you good health.
Thanks.
Allergies can not cause endometrial cancer.
Detailed Answer:
Hello dear, thanks for your question on HCM.
I can understand your situation and problem.
Endometrial carcinoma is not caused by any allergy. There is no literature supporting this association.
Old age is the risk factor for endometrial carcinoma. And at your age of 62 years, chances are high.
Other probable causes are
1. Nulliparity
2. High estrogen levels
3. Delayed menopause
4. Smoking
5. Associated breast or colon cancer etc.
It is having many causes as mentioned above and no literature mentioned about allergies as a cause.
So in your case, it is not possible to prove that allergies is the cause for your endometrial carcinoma because no literature or study is available to support it and your age (62 years) can be the risk factor for endometrial carcinoma.
Hope I have solved your query.
I will be happy to help you further.
Wish you good health.
Thanks.
Above answer was peer-reviewed by :
Dr. Shanthi.E
Titanium Implants Can Cause Cancer
Another complication of the use of implanted titanium is its potential to induce the abnormal proliferation of cells (neoplasia), which can lead to the development of malignant tumors and cancer. Through rare, it is a well-known complication of orthopedic surgery that involves the implantation of metallic hardware. (Extract from anaturalcure.com) +
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Date of Publish: 06/08/2006 (extract from Melisa Metal Allergy Testing)
Increased levels of transition metals in breast cancer tissue (so if possible for Breasts, why not reproductive system ?)
Ionescu J, Novotny J, Stejskal V, Latsch A, Blaurock-Busch E, Eisenmann-Klein M. Neuro Endocrinol Lett 2006; 27(Suppl 1): 36-39
The content of heavy and transition metals in 20 breast cancer biopsies and 8 healthy biopsies was assessed by a standardized Atomic Absorption Spectrofotometry and Inductive Coupled Plasma–Mass Spectroscopy technique. A highly significant accumulation of iron (p<0.0001), nickel (p<0.00005), chromium (p<0.00005), zinc (p<0.00001), cadmium (p<0.005), mercury (p<0.005), and lead (p< 0.05) was found in the cancer samples when compared to the control group. The data suggest that pathological accumulation of transition metals in breast tissue may be closely related to the malignant growth process.
Another complication of the use of implanted titanium is its potential to induce the abnormal proliferation of cells (neoplasia), which can lead to the development of malignant tumors and cancer. Through rare, it is a well-known complication of orthopedic surgery that involves the implantation of metallic hardware. (Extract from anaturalcure.com) +
---------------------------------------------------------------------
Date of Publish: 06/08/2006 (extract from Melisa Metal Allergy Testing)
Increased levels of transition metals in breast cancer tissue (so if possible for Breasts, why not reproductive system ?)
Ionescu J, Novotny J, Stejskal V, Latsch A, Blaurock-Busch E, Eisenmann-Klein M. Neuro Endocrinol Lett 2006; 27(Suppl 1): 36-39
The content of heavy and transition metals in 20 breast cancer biopsies and 8 healthy biopsies was assessed by a standardized Atomic Absorption Spectrofotometry and Inductive Coupled Plasma–Mass Spectroscopy technique. A highly significant accumulation of iron (p<0.0001), nickel (p<0.00005), chromium (p<0.00005), zinc (p<0.00001), cadmium (p<0.005), mercury (p<0.005), and lead (p< 0.05) was found in the cancer samples when compared to the control group. The data suggest that pathological accumulation of transition metals in breast tissue may be closely related to the malignant growth process.
Brief Answer:
This is true for local site, not for distal site.
Detailed Answer:
Hello dear, thanks for your follow up question on HCM.
This is true for local site not for distal site.
Titanium implants can cause allergies in the local, knee joint and can produce malignant proliferation.
But honestly speaking incidence of this is again very very rare (less than 0.01%).
And it takes at least 4-5 years, 1year is too early for the development of cancer.
And if at all occurs, it occurs at local site, knee joint.
By no means it can develop endometrial carcinoma (at distal site).
And you can not deny the fact that old age (62 years) is an independent and biggest risk factor.
So in your case, I don't think government will agree for implant allergy as a cause for your endometrial carcinoma.
Hope I have solved your query.
If you are not having further queries, then please close the conversation and rate my answer.
Wish you good health.
Thanks.
This is true for local site, not for distal site.
Detailed Answer:
Hello dear, thanks for your follow up question on HCM.
This is true for local site not for distal site.
Titanium implants can cause allergies in the local, knee joint and can produce malignant proliferation.
But honestly speaking incidence of this is again very very rare (less than 0.01%).
And it takes at least 4-5 years, 1year is too early for the development of cancer.
And if at all occurs, it occurs at local site, knee joint.
By no means it can develop endometrial carcinoma (at distal site).
And you can not deny the fact that old age (62 years) is an independent and biggest risk factor.
So in your case, I don't think government will agree for implant allergy as a cause for your endometrial carcinoma.
Hope I have solved your query.
If you are not having further queries, then please close the conversation and rate my answer.
Wish you good health.
Thanks.
Above answer was peer-reviewed by :
Dr. Shanthi.E
I don't know how old you are but ask yourself when you are 62, if you are old ? You will then remember me...80 is old, not 60 ! Should I ever be able to prove that my cancer is related to the chemicals leaching through my body due to the allergy to my prosthesis, I will ask for a refund. I am extremely vulnerable right now, that is why I reached out to you. I am just trying to save others from having to go through the same.
Brief Answer:
According to the US definition, 60+ is considered as old age.
Detailed Answer:
Hello dear, thanks for your follow up question on HCM.
I can understand your situation and problem.
We doctors go by standard definations only.
And according to UN (United Nations), old age is considered for age more than 60+.
So at 62 years of age, you are definitely belongs to old age.
You can not deny this fact.
And another fact is that old age is independent risk factor for endometrial carcinoma.
You will find thousands of literatures and studies to support this fact.
Implant can cause allergies in susceptible individuals. But malignant transformation is extremely rare. And if at all this happens, it will be at local site of Implant ( knee in your case) and not at distal site like endometrial tissue.
Another point is time duration. Tumours usually don't grow rapidly in 1 year duration.
So, I don't think you will prove that your endometrial carcinoma is due to knee Implant.
I am not discouraging you, but following are the facts which will go against you.
1. Old age (62) is an independent risk factor for endometrial carcinoma.
2. Implant allergy causes local site malignant transformation, not distal site.
3. Time duration of 1year is less for cancer growth.
Hope I have solved your query.
I will be happy to help you further.
Wish you good health.
Thanks.
According to the US definition, 60+ is considered as old age.
Detailed Answer:
Hello dear, thanks for your follow up question on HCM.
I can understand your situation and problem.
We doctors go by standard definations only.
And according to UN (United Nations), old age is considered for age more than 60+.
So at 62 years of age, you are definitely belongs to old age.
You can not deny this fact.
And another fact is that old age is independent risk factor for endometrial carcinoma.
You will find thousands of literatures and studies to support this fact.
Implant can cause allergies in susceptible individuals. But malignant transformation is extremely rare. And if at all this happens, it will be at local site of Implant ( knee in your case) and not at distal site like endometrial tissue.
Another point is time duration. Tumours usually don't grow rapidly in 1 year duration.
So, I don't think you will prove that your endometrial carcinoma is due to knee Implant.
I am not discouraging you, but following are the facts which will go against you.
1. Old age (62) is an independent risk factor for endometrial carcinoma.
2. Implant allergy causes local site malignant transformation, not distal site.
3. Time duration of 1year is less for cancer growth.
Hope I have solved your query.
I will be happy to help you further.
Wish you good health.
Thanks.
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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