Brief Answer:
Pyridoxine TOXICITY is unlikely

Detailed Answer:
Thank you for your question regarding B6 toxicity and whether or not your symptoms of numbness in the tip of 1 thumb and right forearm. Without taking much else of your presentation into consideration I would comment that such a specific and FOCAL collection of symptoms of numbness which have persisted for several years without much change would be very unlikely to represent a metabolic syndrome such as PYRIDOXINE TOXICITY. I agree that the serum value of 75 is elevated over what is considered to be the upper limit of normal which is 50, however, in the whole scheme of things 75 is not considered either what most would consider TOXIC in an individual. Since B6 toxicity is generally not known to occur in the overindulgence of foodstuffs that contain the water soluble B vitamin the lion's share of toxicity in people come from taking actual supplements. And most people who are supplementing themselves to levels of toxicity are likely doing so with doses that are more than 100mg. daily....some perhaps up to 500mg. daily although there are studies to show that even up to 500mg. daily is still not enough in some individuals to cause flagrant and obvious symptoms of toxicity. The daily recommended amount of pyridoxine through dietary or even supplements is 2 mg./day. The upper level of what is considered ENTIRELY SAFE....even in children is 100 mg./day and as I just indicated above there are even safety studies showing that up to 500mg. in some individuals still does not cause toxic symptoms. Again, your level of 75 is elevated but if you are clearly not taking supplements and I'm assuming you would've said something in your introductory comments.

There is a condition that can cause elevated pyridoxine levels in serum called hypophastasia which is a bone and skeletal disorder. I highly doubt you have this disorder because it is usually picked up much earlier in life...nonetheless, if you wanted to talk to your doctor about doing a serum alkaline phosphatase which has markedly REDUCED activity while URINE PHOSPHOETHANOLAMINE is markedly increased then, you could possibly get an idea whether there were any chance you could have this disorder. Again, my bet is you don't have this problem.

Bottom line with your presentation and your numbers would be this....if I were in your position, I would clearly repeat the serum B6 levels.....I wouldn't get terribly excited about the symptoms you're having as related to ANY FORM of pyridoxal toxicity because it simply wouldn't be that restricted for such a long period of time without being treated....

If the B6 levels are now normal then, likely there was a laboratory error or something you ate, or some medication you took at the time of the former level caused a falsely elevated reading, etc.

I'd look for other causes of your symptoms. If a NCV was done was the NEEDLE part of the exam performed? EMG's consist of nerve conduction AND needle studies.

If I've adequately answered your questions could you do me a huge favor by CLOSING THE QUERY and being sure to include some fine words of feedback along with a 5 STAR rating if you feel my answers/suggestions have helped? Again, many thanks for posing your questions and please let me know how things turn out.

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This query has utilized a total of 42 minutes of professional time in research, review, and synthesis for the purpose of formulating a return statement.

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