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Suggest Treatment For Muscle Weakness Inspite Of Having Hypothyroidism

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Posted on Mon, 26 May 2014
Question: I have a hypothyroid condition. For the last 4 months, my thyroid levels have been fluctuating from 5.71 to 0.13 TSH. I am experiencing muscle mass loss and muscle wasting through out my whole body. Is this being caused by the thyroid issue? If yes, what is the name of this condition? Once the thyroid has beeb stabilized using synthroid, how long will it take to recover muscle? What additional steps or treatment can accelerate recovery?
doctor
Answered by Dr. Shehzad Topiwala (2 hours later)
Brief Answer:
Thyroid

Detailed Answer:
I am sorry to note your fluctuating thyroid levels and the muscle problems.

Muscle weakness and associated problems have been very well known to occur with thyroid conditions. They are typically reversible once the thyroid is managed correctly and blood levels are steadily brought into a stable normal range.

To the best of my knowledge there is no published medical literature describing precise recovery times of the muscle problems from thyroid issues. In general, once TSH and free T4 are in the realm of normal and stay that way for several weeks, improvement is to be expected, with full recovery within couple months. Further there is nothing in particular that you can do to expedite recovery, aside from taking the medication correctly

Seeing an endocrinologist in person with regular follow up will certainly help as these specially trained physicians are adept at controlling thyroid properly without major vacillations.

The general target range for the TSH is 0.4 to 2.4 with free T4 in the high normal range, provided you do not have heart related chest pain from coronary disease/irregular heart rhythm problems or severe osteoporosis
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (20 hours later)
Thank-you very much for your previous response.

My thyroid readings have been improving and now are as follows:
TSH 0.4
Free T3 3.4
Free T4 23
On March 18, my readings were as follows:
TSH 0.13
Free T4 22
Free T3 3.3
Since March 21, I have been taking 88 mcg synthroid


Below are additional questions.

1A- Even though my thyroid readings have improved, I feel like I am still losing muscle mass. When will I stop losing muscle mass?

By muscle loss, I mean that I am getting weaker and now unable to walk as well as losing muscle through out my body.

1B- Can the administration of human growth hormone help the situation?


2- I also have the following bizarre symptoms. Are these typical of thyroid conditions? Will they also go away as the thyroid improves.

- Constant (24x7) gurgling sounds in stomach
- Sensation of ligh punches to stomach area, sides of hips, and abdomen
- Some electrical sensations lasting 5-10 seconds in various spots in the body
- Muscle twitches, especially in the neck and throat areas
- Muscle knotting in weak and wasted muscle (eg hands, knees, hips)
- Some muscles are now so fine, they feel like threads

3- On a weekly basis, what rate should I expect the TSH levels to go up?
EG. I am taking weekly thryoid blood tests. On average, how much change should I expect to see each week?

Is there any other action you would advise that I take at this time?
doctor
Answered by Dr. Shehzad Topiwala (4 hours later)
Brief Answer:
Follow up

Detailed Answer:
I have noted your reports

1A

As the thyroid improve, muscle problems are expected to get better. This is called myopathy which can manifest as 'proximal muscle weakness'

However, the current situation should not progressively cause muscle mass loss. You may wish to consult a neurologist to rule a different medical condition that seems to be affecting your muscles

1B

Growth hormone has not been proven to help muscle mass in this situation

2 These symptoms are likely unrelated to the thyroid. But the only way to be 100% certain is to wait 4 weeks till steady blood levels of thyroid are attained. After that whatever improved was likely from thyroid and whatever does not improve in unlikely due to the thyroid

3 TSH is not supposed to be checked weekly. it is scientifically inappropriate to do so. You should check it only 4 to 6 weekly intervals and even then it will take a few months to fully normalize. This is known in endocrine circles as the 'lagging behind' phenomenon implying that it would be misleading to go by the TSH during this time, and one needs to follow the free T4 levels. if the latter is in normal range, the thyroid is virtually normalized and it is only a matter of time before TSH normalizes too. But as the tSH recovers, it does not mean your thyroid is off because the free T4 is normal.

My suggestion is you should let your endocrinologist manage the thyroid as it requires considerable expertise and finesse.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (19 hours later)
Thank-you once again for the last round of feedback. Additional questions are as follows:

1- Clarification of Previous Response

You mentioned that the 'current situation should not cause muscle mass loss". Do you mean that my current thyroid readings are satisfactory and therefore I should not be any longer experiencing muscl mass loss?

You recommended waiting '4-weeks for steady blood levels' to be attained to rule out thyroid condition as the cause for the other symptoms. Can you clarify 4-weeks from what point? (EG. 4-weeks from start of the 88 mcg dose?)

You mentioned following the free T4 levels - what is the normal range for free T4?

You indicated that the muscle mass loss I am describing may be unrelated to the thyroid condition. What leads you to believe this?


2- Vitamin Related Questions
I am vitamin D3 deficient. Does this deficiency impact the thryroid in any way?

I take vitamins, glucosamine, chondritin, MSM. Are any of these in conflict with synthroid?

3- What are the longer term consequences of having fluctuating thyroid levels?

4- Muscle mass related questions
Is there a test (eg blood test) that lets you determine if muscle breakdown is continuing to occur.

Do you have any advice on how to increase muscle mass quickly?

5- TSH Values
In Canada, the labs list TSH of 0.35 to 5.0 as normal. You mentioned a different range. Is there a uniform standard accepted by endocronologists in North America?


6- Stem cell treament and thyroid
I will be undergoing stem cell therapy which may cause fluctuations in my thyroid. Do you have any experience with such cases - is there any post stem cell treatment monitoring regime that you would recommend?


Thank-you very much for your help.
doctor
Answered by Dr. Shehzad Topiwala (2 hours later)
Brief Answer:
Second Follow up

Detailed Answer:
1- Clarification of Previous Response

You mentioned that the 'current situation should not cause muscle mass loss". Do you mean that my current thyroid readings are satisfactory and therefore I should not be any longer experiencing muscl mass loss?

Answer : They are not at goal at the moment but they are not grotesquely abnormal to justify the severe muscle complaints you have

You recommended waiting '4-weeks for steady blood levels' to be attained to rule out thyroid condition as the cause for the other symptoms. Can you clarify 4-weeks from what point? (EG. 4-weeks from start of the 88 mcg dose?)


Answer: 4 weeks from start of 88 mcg dose

You mentioned following the free T4 levels - what is the normal range for free T4?

Answer: This varies from lab to lab. Please go by your lab's reference range printed on the provided report next to your values

You indicated that the muscle mass loss I am describing may be unrelated to the thyroid condition. What leads you to believe this?

Answer: As mentioned above, the thyroid numbers are not severely abnormal to explain the striking muscle problems you are reporting. But there is no one test to prove either way, as to whether or not the thyroid is responsible

2- Vitamin Related Questions

I am vitamin D3 deficient. Does this deficiency impact the thryroid in any way?

Answer: No. But it can also cause muscle weakness. Aim to normalize your vitamin D levels in the 30 to 50 range

I take vitamins, glucosamine, chondritin, MSM. Are any of these in conflict with synthroid?

Answer: Yes potentially. It is best to keep them away form the time you take the synthroid to ensure synthroid gets adequately absorbed from the gut

3- What are the longer term consequences of having fluctuating thyroid levels?
Answer: The body will feel out of balance in terms of the effects of thyroid hormones, such as body weight and energy levels for example.


4- Muscle mass related questions

Is there a test (eg blood test) that lets you determine if muscle breakdown is continuing to occur.

Answer: Yes, it is called Creatine Kinase.

Do you have any advice on how to increase muscle mass quickly?

Answer: There are no quick ways to do so quickly in a medically safe manner. Kindly see an Exercise Physiologist to go about this in a scientifically appropriate way.

5- TSH Values

In Canada, the labs list TSH of 0.35 to 5.0 as normal. You mentioned a different range. Is there a uniform standard accepted by endocronologists in North America?

Answer: The ranges vary from lab to lab but in general 0.4 to 4.12 is acceptable as per the American Thyroid Association. The Canadian labeling is not that far off from this.



6- Stem cell treament and thyroid

I will be undergoing stem cell therapy which may cause fluctuations in my thyroid. Do you have any experience with such cases - is there any post stem cell treatment monitoring regime that you would recommend?
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (3 days later)
Thanks for the advice on seeing a neurologist and endocronologist; the earliest I could schedule appointments is in XXXXXXX I am working through my GP on thyroid matters until the endocrinologist appointment happens. In the meanwhile I wanted to ask these additional questions.

QUESTIONS – SYNTHROID DOSE RELATED
===========================
A- You mentioned in one of the previous e-mails that my thyroid readings were not “on goal”. What would “on goal” look like?

B- After 4-weeks on the 88 mcg synthroid dose my muscle symptoms have not disappeared – the tissues feels better at 88 mcg but still does not feel normal. The muscle knotting and popping sounds have reduced from before but have not gone away. Joints and muscles still feel separate from one another – better feeling than before but not right.

I am considering requesting a change to my synthroid dose to one of taking 75 mcg couple of times a week for the purpose of seeing if this further improves symptoms. Is this a reasonable and safe thing to do?

With this change, do you expect that the TSH value will move closer to the mid-range of acceptable values? (I realize you have advised monitoring T4 levels; the standard tests that I am getting are measuring TSH levels.)



QUESTIONS - GRAVES DISEASE
====================

Do my symptoms point at all to Graves disease? How do I get tested for Graves disease? Which blood test should I ask for?

doctor
Answered by Dr. Shehzad Topiwala (5 days later)
Brief Answer:
Third follow up

Detailed Answer:
Hi,


Sorry for the delay in my response.


You mentioned in one of the previous e-mails that my thyroid readings were not “on goal”. What would “on goal” look like?

Answer: By goal, I mean the normal range (laboratory specific).

B- After 4-weeks on the 88 mcg synthroid dose my muscle symptoms have not disappeared – the tissues feels better at 88 mcg but still does not feel normal. The muscle knotting and popping sounds have reduced from before but have not gone away. Joints and muscles still feel separate from one another – better feeling than before but not right.

Answer: As I mentioned earlier, it does take time for the muscle tissue to regain normal qualities. Some time, in weeks or months is needed for the hormone levels to stay within normal range for the muscle to regain its health.

I am considering requesting a change to my synthroid dose to one of taking 75 mcg couple of times a week for the purpose of seeing if this further improves symptoms. Is this a reasonable and safe thing to do?

Another: It’s not safe. Do not titrate the dosage of the medication on your own. It needs a lot of insight and details of your clinical condition after examination to ascertain the dosage needed. Leave this to your treating endocrinologist.

With this change, do you expect that the TSH value will move closer to the mid-range of acceptable values? (I realize you have advised monitoring T4 levels; the standard tests that I am getting are measuring TSH levels.)

Answer: Yes, it does. But it takes time for the TSH to reflect your actual thyroid status.



QUESTIONS - GRAVES DISEASE
====================

Do my symptoms point at all to Graves disease? How do I get tested for Graves disease? Which blood test should I ask for?

Answer: No your symptoms do not point at Graves disease. But it is always good to rule out the same. Determination of Thyroid-stimulating antibodies is one such test. It’s a blood test.

Regards,

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (34 hours later)
Thanks for the response. More questions follow:

#1- If I am on the right dose of Synthroid, should the muscle popping sound stop?

#2- Is there any test for measuring normal parathyroid function?

#3- What are the other hormones that need to be checked for balance - please list. (I am reaching menopause age.)


Kind Regards
doctor
Answered by Dr. Shehzad Topiwala (6 days later)
Brief Answer:
Fourth follow up

Detailed Answer:
Hi,

I sincerely apologise for the delay. This is due to very busy clinical schedule I am going through.

Answers for your query.

#1- If I am on the right dose of Synthroid, should the muscle popping sound stop?

Answer: It does help to stop the muscle problem but for sure I takes time may be weeks to months.

#2- Is there any test for measuring normal parathyroid function?

Answer: Serum Parathyroid hormone levels, Serum calcium levels (free and protein bound), Bone mineral density, Vit D3 levels and Calcitonin levels help to assess the parathyroid function.

#3- What are the other hormones that need to be checked for balance - please list.

Answer: In addition to the above, do get Thyroid auto-antibodies test, Follicle-stimulating hormone (FSH) and estrogen (estradiol) and Dihydrotestosterone (DHT) levels which help to determine the hormonal status during menopause or perimenopusal age.

Regards,
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (22 hours later)
SUMMARY INFORMATION:
On March 21, I started on 88 mcg synthroid. My readings were
TSH 0.13
Free T4 22
Free T3 3.3

On April 21, I switched to 75 mcg synthroid to help relieve some of the irregular symptoms I was continuing to experience. My readings as of April 28 were as follows:

TSH 0.51
Free T4 22
Free T3 3.3


My questions are:

1- What is the TSH value needed for muscles to attain normal quality.

2- How long will it take for my TSH level to get to a value of 2-3.

3- Do you have experience with management of thyroid when undergoing stem cell therapy. If not, are you able to point to any literature or contacts on this topic?


Kind Regards
doctor
Answered by Dr. Shehzad Topiwala (3 days later)
Brief Answer:
5th follow up

Detailed Answer:
Hi,

1- What is the TSH value needed for muscles to attain normal quality.
Answer: If the value lies within the normal range for few weeks. It will do.

2- How long will it take for my TSH level to get to a value of 2-3.
Answer: Its subjective

3- Do you have experience with management of thyroid when undergoing stem cell therapy. If not, are you able to point to any literature or contacts on this topic?
Answer: I am sorry I can’t help you in this regard.

I do not have anything that adds value to your questions.

Regards,
Note: For further follow up on related General & Family Physician Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Shehzad Topiwala

Endocrinologist

Practicing since :2001

Answered : 1663 Questions

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Suggest Treatment For Muscle Weakness Inspite Of Having Hypothyroidism

Brief Answer: Thyroid Detailed Answer: I am sorry to note your fluctuating thyroid levels and the muscle problems. Muscle weakness and associated problems have been very well known to occur with thyroid conditions. They are typically reversible once the thyroid is managed correctly and blood levels are steadily brought into a stable normal range. To the best of my knowledge there is no published medical literature describing precise recovery times of the muscle problems from thyroid issues. In general, once TSH and free T4 are in the realm of normal and stay that way for several weeks, improvement is to be expected, with full recovery within couple months. Further there is nothing in particular that you can do to expedite recovery, aside from taking the medication correctly Seeing an endocrinologist in person with regular follow up will certainly help as these specially trained physicians are adept at controlling thyroid properly without major vacillations. The general target range for the TSH is 0.4 to 2.4 with free T4 in the high normal range, provided you do not have heart related chest pain from coronary disease/irregular heart rhythm problems or severe osteoporosis