Question: My wife was prescribed vancomycin for 14 days, 250 mg 4x daily. for a c.diff. infection and SIBO. She was also prescribed cholestyramine resin, 9 g, to take at bedtime dissolved in liquid, to address excessive bile pooling in her stomach, as well as to bind to the c.diff. and help with its expulsion. As expected, the vancomycin gave her nausea, cramping and diarrhea almost immediately. Half way into the course of the antibiotic she added (on her own initiative ) Florastor (Saccharomyces boulardii) 500 mg. 2x daily, a probiotic yeast that is not killed by antibiotics and that some studies have shown to be helpful in preventing a c.diff. relapse, and rebuilding a good flora environment in the colon after antibiotic therapy.. She finished the course of vancomycin four days ago, but is still taking the cholestyramine resin and the Florastor. She is also still experiencing nausea and intestinal cramping, as well as loose stools (not exactly diarrhea). I would have thought that the vancomycin would be out of her system by now. So, could it be the cholestyramine resin and/or the Florastor that is causing the continued nausea and cramping? Suggestions?

Thank you for your reply. She took the Cholestyramine last night at 10:00 p.m. and hasn't taken any more of this drug since then. It is now over 14 hours since she last took it, and she is still having nausea and abdominal pain, but no diarrhea. Do you think that it could still be the Cholestyramine causing this? She hasn't taken anything else except the Florastor (Saccharomyces boulardii).