Brief Answer:
Could be medication REACTIONS

Detailed Answer:
Good evening. Thank you for your question and concern.

Your symptoms could be the result of medication side effects. Though it may be tempting to think about interactions between the 2 medications in reality no significant drug to drug interactions are known to occur with these agents.

However, let's take a look at the side effects for REQUIP- The following are defined as being the most significant:

Nausea (40-60%), Dizziness (6-40%), Somnolence (11-40%), Syncope (1-12%),
Vomiting (12%), Fatigue (8-11%), Viral infection (11%), Dyspepsia (10%)

The side effects for HORIZANT considered the most significantly reported ones are- Somnolence/sedation (10-27%), Dizziness (13-30%), Headache (7-15%),
Fatigue/asthenia (6-10%).

Therefore, the symptoms of dizziness and the look of being asleep for a few seconds in my opinion point at medication side effects of either or even BOTH medications WITHOUT really interacting with one another.

If I were your treating physician in this circumstance I would re-evaluate the need for BOTH drugs and eliminate whichever one seems to be least effective of the 2 for your symptoms. I also subscribe to a plan of medication administration that can be summarized by the little poetic reminder:

1. START LOW
2. GO SLOW
3. LET IT FLOW

What I mean to say is that whatever medication I start using in patients with pain syndromes I start at the lowest dose possible expected to treat the problem and then, SLOWLY escalate the dose to the highest levels possible until either we start getting therapeutic results or intolerable side effects. That means we LET IT FLOW (the medication) and we don't change to other medications too rapidly before we know for sure the original choice for sure didn't work or couldn't be tolerated....make sense?

Of course, I don't know what your history has been with the RLS (more modern terminology- Complex Regional Pain Syndrome0 CRPS) and what other medications or doses you've tried but I typically start with gabapentin, escalate it as I described to you and then, either ADD something else or switch off to another agent such as LYRICA or pregabalin. I don't usually like using variations of gabapentin such as Horizant since minimum doses in the latter may be more than patients can tolerate....and I can't titrate them any less....while gabapentin can be titrated extremely tightly since it is even available in a suspension.

At any rate there are many other ways to handle this type of situation but I believe you are simply overmedicated by either one or two drugs and the fix will be relatively easy. I simply recommend that your physician consider my little memory minder:

1. START LOW
2. GO SLOW
3. LET IT FLOW

If I've adequately answered your questions could you do me a huge favor by CLOSING THE QUERY and being sure to include some fine words of feedback along with a 5 STAR rating if you feel my suggestions have helped? Again, many thanks for posing your questions and please let me know how things turn out.

Do not forget to contact me in the future at: www.bit.ly/drdariushsaghafi for additional questions, comments, or concerns having to do with this topic or others.

This query has utilized a total of 53 minutes of professional time in research, review, and synthesis for the purpose of formulating a return statement.

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