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Suggest Ways To Rule Out Hemochromatosis

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Posted on Sun, 17 Jan 2016
Twitter Sun, 17 Jan 2016 Answered on
Twitter Thu, 11 Feb 2016 Last reviewed on
Question : NAFL, hepochrometis or what's going on here with the few clues provided?
doctor
Answered by Dr. Panagiotis Zografakis (33 minutes later)
Brief Answer:
can't say for sure

Detailed Answer:
Hello,

your results can be caused by various conditions. I'm making a list:
- fatty liver: an ultrasound scan should suffice to prove it.
- alcohol consumption, particularly taking into account the high gamma-GT.
- other inflammatory diseases like rheumatoid arthritis may cause a high ferritin level (ferritin rises when an inflammatory process is active).
- various causes of liver injury (ferritin is released when liver cells die).
- hemochromatosis: the ferritin levels are usually expected to be higher. Checking the iron saturation is a good screening test. A normal saturation excludes iron overload. An MRI of the liver may prove iron overload. Liver biopsy is the best test to reveal it.

Please remember that lab tests are interpreted in the context of clinical information, so your symptoms and other findings may be important. If no symptoms (or other problems) are present then I would guess that fatty liver or alcohol consumption are the most likely causes.

I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.

Kind Regards!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Panagiotis Zografakis (3 minutes later)
I'm not much of a drinker so I'm really curious about the GGT... The ferritin levels and GGT have dramatically gone up over the last year and 1/2.. the ferritin GGT went from under 300 to 500 in one year...

Is this chronic/acture and will lifestyle/weight loss bring back down the AST/GGT/Ferr?
doctor
Answered by Dr. Panagiotis Zografakis (14 minutes later)
Brief Answer:
gradual elevation is suspicious

Detailed Answer:
A gradual elevation of the enzymes and ferritin levels is suspicious for iron overload but it can't be documented with the current data. Since it took more long enough (more than 1 year) to develop, it's a chronic process probably.

The high liver enzymes require radiological assessment of the liver and related organs (pancreas, gallbladder) to determine its cause. An ultrasound scan would be an appropriate first test.

You can't do anything about the enzymes unless you're obese or overweight. In such a case loosing some weight will help.

The polyp seems irrelevant. A surgical consultation is required for it but no enzyme elevations (or ferritin elevation) is expected from it.

Kind Regards!
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3819 Questions

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Suggest Ways To Rule Out Hemochromatosis

Brief Answer: can't say for sure Detailed Answer: Hello, your results can be caused by various conditions. I'm making a list: - fatty liver: an ultrasound scan should suffice to prove it. - alcohol consumption, particularly taking into account the high gamma-GT. - other inflammatory diseases like rheumatoid arthritis may cause a high ferritin level (ferritin rises when an inflammatory process is active). - various causes of liver injury (ferritin is released when liver cells die). - hemochromatosis: the ferritin levels are usually expected to be higher. Checking the iron saturation is a good screening test. A normal saturation excludes iron overload. An MRI of the liver may prove iron overload. Liver biopsy is the best test to reveal it. Please remember that lab tests are interpreted in the context of clinical information, so your symptoms and other findings may be important. If no symptoms (or other problems) are present then I would guess that fatty liver or alcohol consumption are the most likely causes. I hope you find my comments helpful! You can contact me again, if you'd like any clarification or further information. Kind Regards!