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What Are The Chances Of Neuropathy When The Nerve And Muscle Test Results Are Normal?

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Posted on Thu, 9 Apr 2015
Twitter Thu, 9 Apr 2015 Answered on
Twitter Fri, 1 May 2015 Last reviewed on
Question : HI,The nerve & muscle test was normal. I don't have a copy of the results but can get it later. However, after I returned home, I did some research and discovered that small fibre neuropathies often do not show up on these tests and since I do an assymetric distribution patter (dysthesia - burning or coolness) with a predominance in the arms, I think that I may get some v bad news (paraneoplastic syndrome) once all of the necessary tests are done. The chest x-ray was repeated last week and nothing was found but from what I read, that is not at all uncommon with this type of disease. I have checked for all of the other types of neuropathy and nothing else seems to fit. I believe that radiculopathies almost always produce numbness or some motor deficit. I previously had an MRI (multi-level degenerative disc disease & multi-level right foraminal stenosis which I was also told would not produce the symptoms that I have.) I have an appointment with an internist on Monday. I am v scared.

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doctor
Answered by Dr. Ajay Panwar (12 hours later)
Brief Answer:
If NCS-EMG is normal,proximal neuropathy is ruled out.

Detailed Answer:
Hi,
Thanks for being in follow-up.I appreciate.

Continuing with respect to our last discussion,I still feel it is spine degeneration radiculopathies which are causing these symptoms.
Though,you are correct in saying that Nerve conduction studies(NCS) may come normal in small fibre neuropathy but the kind of presentation you are having is not the one of small fibre neuropathy.A small fibre neuropathy is usually a typical length dependent peripheral neuropathy and not the asymmetric proximal type of neuropathy.So,you are not having a small fibre neuropathy.

So,neuropathy is not established as a diagnosis as yet and you are just presuming it.Rather,with the background of multi-level degeneration of spine with foraminal stenosis,I would still go with the radiculopathy as the diagnosis,secondary to spine changes.

Don't be anxious as even chest X-ray has turned out normal again.Please upload Nerve and muscle tests reports,so that I can make a better opinion.I suggest you to get Nerve conduction studies done on Brachial plexus protocol along with F-waves.Please discuss with your electrophysiologist regarding this.At the same time,I want to have a look at MRI also.

Hope I have answered your query for now.I shall be glad to have you in follow-up.

Dr.Ajay Panwar,
MD,DM(Neurology)
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Ajay Panwar (5 days later)
I cannot thank you enough for your vigilant response. I just had a pin-prick type of test the other day and the results were totally abnormal -- one side was different from the other in numerous places in my legs and arms all the way up to my head. The new neurologist did not do further testing because he wants to see all of my previous records first. I am very frustrated because he does not have another appointment for me until XXXXXXX 19th. (and I really do feel that time is of the essence and they are taking so long) I think I should have an FDG-PET scan asap but it appears almost impossible to get one now--I am going out tomorrow to try. (not sure what you would think of this but I feel that I must rush things along) I also have to fax in a referral for a rheumatologist but this may also take a few months according to the secretary, depending upon how urgent they think my case is. I can try to see someone else sooner, esp for the autoimmune antibodies tests. I feel like I must hurry-- there is this sense that my life could be in grave danger. (a year and three months has already gone by and everyone seems to be quite indifferent to the situation at hand---I feel like I am just another number going through the system at a time when something much more is warranted) I will try and get the information that you requested within the next week or so--as soon as I can. My arms, back and legs are freezing in particular areas--what is most disarming to me is that the symptoms are always there (more predominant in the arms -- appears to be worse while I am sitting.) I am afraid that I could develop encephalitis or suffer some other neurological side-effect. I also keep remembering that the post menopausal bleeding occured a month and a half after the sudden onset of these neuropathic-like symptoms--hence, the strong suspicion of an autoimmune type of paraneoplastic syndrome. (I know that it is more likely to be associated with lung than gynecological cancer so that could also be another grim possibility) I had read online that small fibre sub-acute sensory neuropathy could also be associated with this syndrome in the assymetric fashion but now you have at least provided me with some counter-balance which is no doubt based upon your professional knowledge and experience. I just got a call a few weeks ago telling me that they have discovered abnormal cells in my uterus afterall. (the results showed no cancer at Christmas time but now they are going to do another biopsy. I had an operation to remove a very large endometrial polyp in November. (the hospital is moving to a new location so they will be following up with me sometime in May) Thanks again. I truly value your wisdom and perspective------will be in touch as soon as I have the info that you requested.

Small fibre neuropathies are also associated with more intense burning and coldness which correlates. The abnormal pin-prick results are also indicative of a neuropathy, are they not?
doctor
Answered by Dr. Ajay Panwar (46 minutes later)
Brief Answer:
Hard points against small fibre neuropathy.

Detailed Answer:
Hi,
Thanks for being in follow-up,appreciating and providing further details.

I do not agree at this point for you having small fibre neuropathy.You had abnormal pin prick in patchy areas on one side,including leg,arm and head-this description of your's itself clearly rules out small fibre neuropathy.
Points against small fibre neuropathy-
1)non-uniform or patchy sensory loss
2)non-symmetrical
3)non length dependent
4)involving head
So many hard points against it.

However,you should continue with your gynecological checkup as paraneoplastic and autoimmune can present atypically.

But,my probable diagnosis still remains radiculopathies due to spine degeneration.So,please follow up with reports.

Hope that I have answered your query for now.If you have no further questions,please close the thread-rate it and write a review as your rating will be of help to me.

Regards
Dr.Ajay Panwar,
MD,DM(Neurology)
Above answer was peer-reviewed by : Dr. Neel Kudchadkar
doctor
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Follow up: Dr. Ajay Panwar (10 hours later)
Thank-you for your wonderful follow-up. I will be in touch.
doctor
Answered by Dr. Ajay Panwar (3 minutes later)
Brief Answer:
I shall be glad.

Detailed Answer:
Hi,
Thanks for being in follow-up and appreciating.

Even I shall be glad to have you in follow-up and it will be a pleasure to have a constant monitoring of your clinical condition.

Hope that I have answered your query for now.If you have no further questions,please close the thread-rate it and write a review as your rating will be of help to me.

Regards
Dr.Ajay Panwar,
MD,DM(Neurology)
Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Dr. Ajay Panwar

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What Are The Chances Of Neuropathy When The Nerve And Muscle Test Results Are Normal?

Brief Answer: If NCS-EMG is normal,proximal neuropathy is ruled out. Detailed Answer: Hi, Thanks for being in follow-up.I appreciate. Continuing with respect to our last discussion,I still feel it is spine degeneration radiculopathies which are causing these symptoms. Though,you are correct in saying that Nerve conduction studies(NCS) may come normal in small fibre neuropathy but the kind of presentation you are having is not the one of small fibre neuropathy.A small fibre neuropathy is usually a typical length dependent peripheral neuropathy and not the asymmetric proximal type of neuropathy.So,you are not having a small fibre neuropathy. So,neuropathy is not established as a diagnosis as yet and you are just presuming it.Rather,with the background of multi-level degeneration of spine with foraminal stenosis,I would still go with the radiculopathy as the diagnosis,secondary to spine changes. Don't be anxious as even chest X-ray has turned out normal again.Please upload Nerve and muscle tests reports,so that I can make a better opinion.I suggest you to get Nerve conduction studies done on Brachial plexus protocol along with F-waves.Please discuss with your electrophysiologist regarding this.At the same time,I want to have a look at MRI also. Hope I have answered your query for now.I shall be glad to have you in follow-up. Dr.Ajay Panwar, MD,DM(Neurology)