What Are The Consequences Of Taking 1900mg Of Zoloft And 450mg Of Mirtazapine?

Posted on Wed, 1 Apr 2015

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Wed, 1 Apr 2015 Answered on

Thu, 23 Apr 2015 Last reviewed on

Question : what would happen if i took 1900mg of zoloft and 450mg of mirtazapine

Answered by Dr. Dr. Chintan Solanki (54 minutes later)

Brief Answer:
it may be fatal, if you have taken consult emergency medical services

Detailed Answer:
Hello,

Thanks for writing to us.

Sertraline(Zoloft) 19 gm is very much high toxic dose. It can cause serotonin syndrome.Seizures, Arrhythmia, rhabdomyolysis,disseminated intravascular coagulation, Acute renal failure,respiratory failure, bradycardia, bundle branch block, coma, delirium, hallucinations, hypertension, hypotension, manic reaction, pancreatitis, QT-interval prolongation, stupor, syncope and Torsade de Pointes anything can happen with such dose.
In conclusion this is very fatal dose and can lead to death.

Mirtazapine 450 mg is relatively less toxic than zoloft. It can cause tachycardia otherwise no specific clinical or ecetrocardiography changes.

Hope you are just asking that what would happen if such doses are taken.

By chance if you have taken please consult emergency department for treatment.

Hope I have answered your query, I will be happy to help further.

Regards,
Dr.Chintan Solanki.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Chintan Solanki (6 hours later)

thank you for your answer. i now know that it will do what i want

Answered by Dr. Dr. Chintan Solanki (6 minutes later)

Brief Answer:
Please do not do any thing which can harm you

Detailed Answer:
Hello XXXX,

I have given answer as we are here for the same.But being a doctor my duty is to see that no one should be in pain and I should try my best to help you in your problem.

I request you to do not take overdose of any medicine for any purpose if you are thinking so. If you have any problem or any psychiatric disorder, you can be treated.

Let me know if you are in any trouble. Or just tell someone very close to you or at least consult your GP or psychiatrist.

If nothing serious, then it is ok.

Take care.

Http://bit.ly/drchintansolanki

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Chintan Solanki (3 minutes later)

i suffer from complex PTSD and i cant live like this anymore. dont know what else to do.

Answered by Dr. Dr. Chintan Solanki (1 hour later)

Brief Answer:
Thanks for reply, I need more details,Complex PTSD can be treated

Detailed Answer:
Dear XXXX,

Thanks for reply and positive approach. You are only 36. Still many years of life is there.
Your situation seems to be very severe as you feel to end your life.

But believe me there is always hope.

Post traumatic stress disorder is a type of anxiety-stress disorder. It can be treated with psychotherapy and medicines.

In psychotherapy CBT-cognitive behaviour therapy and psychodynamic therapy are useful while in medicines SSRI group,specifically paroxetine and Benzodiazepine group of drugs are useful.

You have used word 'complex'. I would like to know what do you want to explain by it.

Please write your detail history with onset of symptoms,medication tried, family and education background and current factors/symptoms which are so frustrating that you do not want to live.

Write to the point and try to include all important all details. I will read carefully.I will try my best to help you as much as possible.

If you do not want to write , please consult your doctor and narrate your situation. If you feel that current doctor is not able to help, consult another doctor. But please give a chance before you think to take any wrong step.

You can ask follow up query and write details in this communication chain or contact me directly also on this site with following link

http://bit.ly/drchintansolanki

Waiting for your reply to help you further.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Chintan Solanki (36 hours later)

thanks for trying to help but goodbye.

Answered by Dr. Dr. Chintan Solanki (3 hours later)

Brief Answer:
Please try to follow advice given

Detailed Answer:
Hello XXXX,

Again I request you that give yourself a chance. Life can be changed. Time does not remain always the same.

Please follow advice given in previous answer.

Take care.

Above answer was peer-reviewed by : Dr. Neel Kudchadkar

Follow up: Dr. Dr. Chintan Solanki (46 minutes later)

i was diagnosed with PTSD about 17years ago and have been on 300mg of zoloft for most of that time except while pregnant. I was sexually abused by my brother for the age of 6-18. my family do not want anything to do with me and my husband gates how i sm down all the time and then we argue which effects the kids. have tried different types of therapy. they have worker for a little while but nothing seems be working at the moment. don't know what else to do. i just think that everyone will be better off without me.

Answered by Dr. Dr. Chintan Solanki (3 hours later)

Brief Answer:
paroxetine and lithium can help

Detailed Answer:
Hello,

Thanks for reply. I am thankful to you that you have provided some information.I can understand your helplessness and loneliness.

Your thought "everyone will be better off without me" will not be true in reality.Children without mother suffers a lot. For them you need to gather the strength for your improvement.

You have mentioned that you had tried different types of therapies. Which are they?

In my opinion Paroxetine for PTSD as well as lithium in resistant depression with suicidal thoughts work better. If you have not tired them ask your doctor to start the same medicines.

Other option is ECT- Electro Convulsive Therapy.It works well in patients with suicidal ideas.

Have you undergone CBT- cognitive behavior therapy ? If not, it should be started with medicines.

If possible please tell me what therapies/medicines you have tried until now.

Feel free to discuss further.

Take care.

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Pradeep Vitta