What Are The Side Effects Of Methotrexate On Bladder And Vagina?

Posted on Wed, 14 Aug 2013

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Wed, 14 Aug 2013 Answered on

Tue, 3 Sep 2013 Last reviewed on

Question : What are the side effects of methotrexate related to the badder and the vagina?

Answered by Dr. Dr. Soumen Patra (1 hour later)

Brief Answer:
Methotrexate has several side effects.

Detailed Answer:
Hello,

Thanks for writing to us.

Side effects occur due to high dose of Methotrexate. The following ones are related to bladder and vagina:

1) Bladder inflammation and cancer (in long term use).
2) Renal impairment and hematuria (bloody urine).
3) Vaginal pruritus (itching) and infection.
4) Vaginal bleeding or spotting.

Folinic acid supplement is given as antidote of Methotrexate toxicity. If the patient suffer from any of these symptoms, it is worthwhile to consult the treating doctor and ask for folinic acid supplement.

Hope, above information is quite helpful. Let me know, if you need any clarification.

Wish your good health. Good luck.

Regards,
Dr Soumen

Above answer was peer-reviewed by : Dr. Prasad