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What Causes MGUS And AT Deficiency?
Question: Im been ask to test my blood as follows Proteins - Electrophoresis With alpha-1antitrpsin level and assessment of possible paraprotein
Clinical Details
?MGUS? ?A1 - AT deficiency?
What do these test mean
Clinical Details
?MGUS? ?A1 - AT deficiency?
What do these test mean
Brief Answer:
Electrophoresis is advised to exclude two conditions.
Detailed Answer:
Hello
Electrophoresis is advised to exclude two conditions MGUS(Monoclonal gammopathy of undetermined significance) and A1-AT(Alpha-1 antitrypsin deficiency)deficiency.
These are biochemical tests and separate different type of proteins.Under the electric field,particles get separated due to different relative motion and charge.It separate macromolecules based on size,density etc.
MGUS is a condition in which an abnormal protein (M protein,paraprotein) is present in blood. M protein is produced by plasma cells(type of white blood cell).
Alpha 1-antitrypsin deficiency is a genetic disorder due to defective production of alpha 1-antitrypsin.It causes decreased A1AT activity in the blood and lungs.
Get well soon.
Hope I have answered your query.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
Electrophoresis is advised to exclude two conditions.
Detailed Answer:
Hello
Electrophoresis is advised to exclude two conditions MGUS(Monoclonal gammopathy of undetermined significance) and A1-AT(Alpha-1 antitrypsin deficiency)deficiency.
These are biochemical tests and separate different type of proteins.Under the electric field,particles get separated due to different relative motion and charge.It separate macromolecules based on size,density etc.
MGUS is a condition in which an abnormal protein (M protein,paraprotein) is present in blood. M protein is produced by plasma cells(type of white blood cell).
Alpha 1-antitrypsin deficiency is a genetic disorder due to defective production of alpha 1-antitrypsin.It causes decreased A1AT activity in the blood and lungs.
Get well soon.
Hope I have answered your query.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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