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What Causes Constant Fatigue, Heart Palpitations, Nausea And Insomnia While On Cytomel?

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Posted on Thu, 9 Jun 2016
Question: For over ten years I took 50 mcg day of cytomel to help with depression. About two months ago this was reduced to 25 mcg Cytomel a day. I am feeling really bad, constant fatigue,heart palpitations, nausea, insomnia. Doctor checked my hormone levels and they are out of whack. TSH = 0.657; FT4 = 0.51; T3 = 224. I am a 57 YR female. What is causing this abnormality?
doctor
Answered by Dr. Shehzad Topiwala (9 hours later)
Brief Answer:
Thyroid

Detailed Answer:
Sorry to note your symptoms.

1 When a person takes cytomel it is often seen that the T4 levels are on the lower side. This is because cytomel is T3

2 Cytomel is generally not recommended by thyroid experts as it is deemed unsafe

3 Thyroid hormone preparations containing T3 alone or in combination with T4 include the following : T3 alone (eg, Cytomel), T4-T3 combination preparations (eg, Thyrolar), and desiccated thyroid (a mixture of T3 and T4 made from porcine thyroid glands, eg, Armour Thyroid).

For most patients with hypothyroidism, thyroid specialists (ie endocrinologists) do not suggest treatment with T3 containing preparations. Patients treated with currently available T3-containing preparations have wide fluctuations in blood T3 levels throughout the day due to its rapid absorption from the gut and its relatively short stay in the circulation.

In addition, blood T4 levels remain low in patients treated with T3, and relatively low in those treated with preparations containing both T3 and T4; while serum TSH in steady state conditions will reflect the adequacy of therapy, measurement of serum T4 may be confusing and lead to inappropriate changes in dose. This is what is exactly being seen on your laboratory report

There are few legitimate uses of cytomel nowadays. One example is this : Temporary treatment with T3 is appropriate in patients with thyroid cancer who are to undergo radioiodine imaging and possible treatment. To shorten the period of hypothyroidism, the patient's T4 therapy is discontinued and T3 is substituted for three to four weeks until the T4 is cleared

4 You will be best served by seeing an endocrinologist in person who will have the opportunity to examine you, and manage the complexities of hypothyroidism

When I see someone like you in my practice, I typically order the following blood tests in addition to a detailed physical examination:

CBC (Complete Blood Count, also known as Hemogram; includes Hemoglobin, WBC and Platelet counts)
Electrolytes (Sodium and Potassium in particular)
HbA1c (Glycosylated Hemoglobin = your 3 month glucose average)
Liver function tests (SGOT , SGPT, Albumin, Bilirubin, Alkaline Phosphatase)
Kidney function tests (BUN, Creatinine)
Anti Thyroid Peroxidase (TPO) antibodies
Anti Thyroglobulin antibodies
25 hydroxy Vitamin D

None of these tests require any fasting and can be done at any time of the day
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (30 hours later)
Hi Dr. Topiwala,

Thank you for such a prompt and thorough reply.

My GP suggested I increase the cytomel. I can't get an appointment with an endocrinologist until XXXXXXX

I stopped the cytomel and today almost passed out. Heart rate was at 50 BPM.

Did I mention I am also having heart palpitations and hair loss??? My cardiologist feels certain it is the cytomel causing the problems as tests ruled out everything else. I also tested negative for antibodies (Graves) and my ultrasound was normal.

So I'm not sure what to do. I can try a half dose of cytomel. I can switch to levothyroxine. Or a combination or the two. My GP isn't sure what to do and is relying on me for advice. I do have a doctorate in Biochemistry but this is way beyond me. Are you able to offer advice here????

Do you do over the phone or web consulting? I'm leaving tomorrow for a two week business trip to Israel and I'm very concerned about my ability to function on this critical trip.

Warm regards
XXXXXXX
doctor
Answered by Dr. Shehzad Topiwala (3 hours later)
Brief Answer:
Follow up

Detailed Answer:
Sorry to inform you that this forum is not meant for prescribing medications.

Phone and Web consulting are not an option either.

You clearly need prompt help especially with your imminent travels.

I sincerely hope you get to see an Endocrinologist immediately.

Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shehzad Topiwala

Endocrinologist

Practicing since :2001

Answered : 1663 Questions

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What Causes Constant Fatigue, Heart Palpitations, Nausea And Insomnia While On Cytomel?

Brief Answer: Thyroid Detailed Answer: Sorry to note your symptoms. 1 When a person takes cytomel it is often seen that the T4 levels are on the lower side. This is because cytomel is T3 2 Cytomel is generally not recommended by thyroid experts as it is deemed unsafe 3 Thyroid hormone preparations containing T3 alone or in combination with T4 include the following : T3 alone (eg, Cytomel), T4-T3 combination preparations (eg, Thyrolar), and desiccated thyroid (a mixture of T3 and T4 made from porcine thyroid glands, eg, Armour Thyroid). For most patients with hypothyroidism, thyroid specialists (ie endocrinologists) do not suggest treatment with T3 containing preparations. Patients treated with currently available T3-containing preparations have wide fluctuations in blood T3 levels throughout the day due to its rapid absorption from the gut and its relatively short stay in the circulation. In addition, blood T4 levels remain low in patients treated with T3, and relatively low in those treated with preparations containing both T3 and T4; while serum TSH in steady state conditions will reflect the adequacy of therapy, measurement of serum T4 may be confusing and lead to inappropriate changes in dose. This is what is exactly being seen on your laboratory report There are few legitimate uses of cytomel nowadays. One example is this : Temporary treatment with T3 is appropriate in patients with thyroid cancer who are to undergo radioiodine imaging and possible treatment. To shorten the period of hypothyroidism, the patient's T4 therapy is discontinued and T3 is substituted for three to four weeks until the T4 is cleared 4 You will be best served by seeing an endocrinologist in person who will have the opportunity to examine you, and manage the complexities of hypothyroidism When I see someone like you in my practice, I typically order the following blood tests in addition to a detailed physical examination: CBC (Complete Blood Count, also known as Hemogram; includes Hemoglobin, WBC and Platelet counts) Electrolytes (Sodium and Potassium in particular) HbA1c (Glycosylated Hemoglobin = your 3 month glucose average) Liver function tests (SGOT , SGPT, Albumin, Bilirubin, Alkaline Phosphatase) Kidney function tests (BUN, Creatinine) Anti Thyroid Peroxidase (TPO) antibodies Anti Thyroglobulin antibodies 25 hydroxy Vitamin D None of these tests require any fasting and can be done at any time of the day