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What Causes Elevated ALT Levels In Blood While On Amlodipine?

Posted on Tue, 28 Jun 2016

Question: I have had a blood test done alt was 49. The doctor ordered a retest a month later Alt is 109 . I abstained from alcohol in case that had affected it. my hep panel was normal uibc was slightly out of range 88 . I have been taking amlodipine for 6 weeks and have taken lisinopril and levothyroxine for a number of years. I have recently lost 23lbs in weight following a low calorie diet.What could be wrong ?

Answered by Dr. Dr. Muhammad Sareer Khalil (2 hours later)

Brief Answer:
Raised ALT

Detailed Answer:
Hello and Welcome

I appreciate your concern

Drug Induced Liver Injury (DILI) can occur with a number of medications. If the ALT is not raised above 4 to 5 times upper limit of normal, there are no signs of hepatic compromise, the viral hepatitis profile is negative and the bilirubin levels are also normal then the medication should be continued just as before. The Liver function tests should be repeated within a week to look for an acutely rising ALT. If present , then the amlodipine can be considered for discontinuation in consultation with your doctor. The rapid weight loss can also be a contributing factor towards the raised ALT.

Wishing you best of health

Thanks

Let me know if you have any query

Please consult your doctor before deciding on any further course of action.

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Dr. M.S. Khalil

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Muhammad Sareer Khalil (8 minutes later)

Thank you is the high uibc significant ?

Answered by Dr. Dr. Muhammad Sareer Khalil (13 hours later)

Brief Answer:
Lab report

Detailed Answer:
Hello again.

The normal iron-binding capacity is 255-450 μg/dL.

The units used by your lab may be different.

If possible then kindly provide the lab report of the raised uibc.

wishing you best of health

Thanks

Dr M.S Khalil

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar