What Causes Elevated Antinuclear Antibodies In Blood?

Posted on Wed, 7 Jun 2017

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Wed, 7 Jun 2017 Answered on

Wed, 28 Jun 2017 Last reviewed on

Question : I received blood work back that shows my titer is 1:640 and my pattern is dense fine speckled. my ena and ddna was negative. is this something i should be concerned about? i don't have any symptoms other than just light headiness and maybe once in a while i might be tired

Answered by Dr. Ornela Ademovi (2 hours later)

Brief Answer:
High titers do not necessarily mean you have Lupus

Detailed Answer:
Hello,

I understand your concern. The high ANA titers are the first step to diagnosing Lupus, however, high titers alone, without symptoms and negative ds DNA or ENA, are found in around 20% of people, especially women, who never develop this disease.
In order to confirm Lupus, a positive anti ds DNA, anti XXXXXXX anti Ro/La, anti U1RNP types of antibodies need to be positive. Which doesn't seem to be the case here.
I hope this answers your question. If you have further questions I'd be happy to help.

Wishing you good health and all the best

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Above answer was peer-reviewed by : Dr. Remy Koshy