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What Causes Excessive Sleeping While On Gabapentin And Benadryl?

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Posted on Mon, 18 Jul 2016
Question: Hi. I am wondering how long proposal stays in the body? I had a colonoscopy and I still was sleepy the next day.
doctor
Answered by Dr. Panagiotis Zografakis (35 minutes later)
Brief Answer:
propofol?

Detailed Answer:
Hello,

I suppose you meant propofol? Propofol's effects after such a short infusion are supposed to wear off in minutes. The patient should feel normal 1 hour after the infusion. Sleepiness the next day is not expected.

Prolonged infusion may cause accumulation of the drug in the fat tissue and according prolongation of its effects but the usual procedure for colonoscopy is a short infusion.

I hope it helps!
Kind Regards!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Panagiotis Zografakis (1 hour later)
I do not understand why I am sleepy the next day? I am 5'7" and 120 lbs. I take gabapentin 200mg and benadryl 50mg at night for sleep. I had the colonoscopy at 2 pm. Why does they handout say you cannot drive?
doctor
Answered by Dr. Panagiotis Zografakis (54 minutes later)
Brief Answer:
perhaps the combination with benadryl...

Detailed Answer:
The drugs you've mentioned (gabapentin and benadryl) cause sleepiness. Using another "sleep" drug will potentiate their effects. Perhaps that's the cause. If you've had a glass of wine (or anything like that) too, then it could also make things worse.

Propofol on its own may only cause sleepiness during the procedure and up to few (maximum) hours after the test. Most patients are fully functional 1 hour or so after the infusion. You should not drive after the test because propofol may reduce your reaction time for a while. Watch it though because the drugs you're already using may do the same!

Kind Regards!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Panagiotis Zografakis (27 minutes later)
Thank you!
doctor
Answered by Dr. Panagiotis Zografakis (8 hours later)
Brief Answer:
you're welcome

Detailed Answer:
You're welcome! Glad to help!
Note: For further follow up on related General & Family Physician Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3810 Questions

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What Causes Excessive Sleeping While On Gabapentin And Benadryl?

Brief Answer: propofol? Detailed Answer: Hello, I suppose you meant propofol? Propofol's effects after such a short infusion are supposed to wear off in minutes. The patient should feel normal 1 hour after the infusion. Sleepiness the next day is not expected. Prolonged infusion may cause accumulation of the drug in the fat tissue and according prolongation of its effects but the usual procedure for colonoscopy is a short infusion. I hope it helps! Kind Regards!