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What Causes False Positive Amphetamine Drug Screening?

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Posted on Mon, 1 Dec 2014
Question: Blood test positive for amphetamine but do not take. Take oxycodone, morphine, Clonazepan, Lamoprigine, carbamazepine, milk of magnesia, occaional benadryl, use ketamine compound and Flur/Armit/Gab/Lido/Prilc for trigeminal neuralgia. Tested positive for morphine but negative for oxycodone. What caused positive for amphetamine?
doctor
Answered by Dr. Dr. Ashok Kumar Choudhary (28 minutes later)
Brief Answer:
This may be due to benadryl

Detailed Answer:
Hello,
Thanks for using healthcaremagic.

I read your query and understand your concerns.

Although false positive amphetamine drug screening is described with many of the agents but antihistamine play a significant role in causing false positive test for amphetamine despite the fact that you never tried this substance.

I like to refer this article at medscape which gives comprehensive picture about this problem. http://www.medscape.com/viewarticle/726897.

It clearly states that " Categories of medications included antihistamines, antidepressants, antibiotics, analgesics, antipsychotics, and nonprescription agents. Reports of false-positive results were found for the following formulary and nonprescription medications brompheniramine, bupropion, chlorpromazine, clomipramine, dextromethorphan, diphenhydramine, doxylamine, ibuprofen, naproxen, promethazine, quetiapine, quinolones (ofloxacin and gatifloxacin), ranitidine, sertraline, thioridazine, trazodone, venlafaxine, verapamil, and a nonprescription nasal inhaler.

False-positive results for amphetamine and methamphetamine were the most commonly reported. "

I like to tell you that Diphenhydramine is nothing else, it is benadryl.

Hope I am able to answer your concerns.
If you have any further query, I would be glad to help you.
If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback.
In future if you wish to contact me directly, you can use the below mentioned link:
http://doctor.healthcaremagic.com/doctors/dr-ashok-kumar/67386
Thanks and regards
Above answer was peer-reviewed by : Dr. Ashwin Bhandari
doctor
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Follow up: Dr. Dr. Ashok Kumar Choudhary (22 hours later)
Taking 4 Benadryl a day. How to convince pain specialist not to drop me but to accept that it's the Benadryl causing the positive amphetamine blood tests.
doctor
Answered by Dr. Dr. Ashok Kumar Choudhary (4 hours later)
Brief Answer:
It is difficult to convince but........

Detailed Answer:
Hello,
Thanks for reverting back to me.

I understand the current issue as many times physician do not believe their patient and more convinced with test.
But whatever the fact you need to deal with available evidence which is available over the internet.
Alternatively call the pharmacist and ask him to provide details about false positive test for amphetamine with benadryl intake. You can show the same evidence to your physician.

Other than that, collect evidence available at pubmed (medical literature). medscape. US drug pharmacy colleges and many more.

Take all the papers and try to convince him that this is due to benadryl and you are not responsible for positive test.

If despite all this he is not convinced ask him to retest for amphetamine using gas chromatography which is advanced technique of measurement and able to differentiate between true amphetamine and benadryl.

'Hope I have answered your query. If you have any further questions I will be happy to help".
Thanks
Note: In case of any other concern or query related to prevention, evaluation, diagnosis, treatment, or the recovery of persons with the any type of addiction or substance use, follow up with our Addiction Medicine Specialist. Click here to book a consultation now.

Above answer was peer-reviewed by : Dr. Bhagyalaxmi Nalaparaju
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Answered by
Dr.
Dr. Dr. Ashok Kumar Choudhary

Psychiatrist

Practicing since :2000

Answered : 3355 Questions

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What Causes False Positive Amphetamine Drug Screening?

Brief Answer: This may be due to benadryl Detailed Answer: Hello, Thanks for using healthcaremagic. I read your query and understand your concerns. Although false positive amphetamine drug screening is described with many of the agents but antihistamine play a significant role in causing false positive test for amphetamine despite the fact that you never tried this substance. I like to refer this article at medscape which gives comprehensive picture about this problem. http://www.medscape.com/viewarticle/726897. It clearly states that " Categories of medications included antihistamines, antidepressants, antibiotics, analgesics, antipsychotics, and nonprescription agents. Reports of false-positive results were found for the following formulary and nonprescription medications brompheniramine, bupropion, chlorpromazine, clomipramine, dextromethorphan, diphenhydramine, doxylamine, ibuprofen, naproxen, promethazine, quetiapine, quinolones (ofloxacin and gatifloxacin), ranitidine, sertraline, thioridazine, trazodone, venlafaxine, verapamil, and a nonprescription nasal inhaler. False-positive results for amphetamine and methamphetamine were the most commonly reported. " I like to tell you that Diphenhydramine is nothing else, it is benadryl. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback. In future if you wish to contact me directly, you can use the below mentioned link: http://doctor.healthcaremagic.com/doctors/dr-ashok-kumar/67386 Thanks and regards