What Causes High WBC Level After Having Nplate?

Posted on Sat, 20 Dec 2014

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Sat, 20 Dec 2014 Answered on

Mon, 5 Jan 2015 Last reviewed on

Question : i took a CBC and my WBC was 18.7 I have ITP and take Nplate weekly. My Platelets were 77 . I continue to have a elevated WBC over 18 fo rthe last 3 months. I have no infection as per tests . My DR says that she feels the high WBC is a reaction caused my the Nplate doing its thing. I was given a antibotic and it did not change the WBC. Whats your opinon ?

Answered by Dr. Hardik Sanghvi (1 hour later)

Brief Answer:
High wbc count may be due to nplate side effect.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
You are taking nplate. It contains romiplostim, a drug that increase your platelet count. Romiplostim can also leads to high wbc count. It is a uncommon side effect of nplate. If you don't have any infection then no need to worry. However repeated complete blood count is advised on treatment of nplate and after stopping of drug.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic.
Wish you a very good health.

Above answer was peer-reviewed by : Dr. Shanthi.E

Follow up: Dr. Hardik Sanghvi (28 minutes later)

My CBC values as of today
Red Blood count 4.82
Hgb13.9
Hemalocrit 43.0
MCV 89
RDW,RBC 13.7
Plateletes 78
WBC18.7
White Blood factors
Neulrophils% automated 35
Lymphocytes automated 60
Monos% 1
Basaphils % 1
neulrophils auto count 6.6

I take 2.50 of Nplate every 7 days

Answered by Dr. Hardik Sanghvi (5 minutes later)

Brief Answer:
No need to worry.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
Your complete blood count report suggests that you have high wbc count with high lymphocytes. You don't have any infection so no need to worry.
Just regularly monitor your wbc count and platelets.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.

Above answer was peer-reviewed by : Dr. Bhagyalaxmi Nalaparaju