Brief Answer: Proper eview required, other possibilities conside Detailed Answer: Hi and thanks for the query, It is imperative to be sure that the swelling was due to fluid overload. HZT is a diuretic that acts by simply increasing the amount of water lost in the body. HZT in the process of fluid loss can be accompanied by loss of some electrolytes (ions) like Calcium and Magnesium. These are substances greatly involved in the transmission of nervous messages. They could to some extent explain the numbness. It is also very possible that the numbness might not actually be directly related to the use or non use of the diuretic. It could be interesting to know how well your blood sugar has been controlled lately. Diabetes predisposes persons to develop some abnormality called peripheral neuropathy. A complete and yearly foot exam to check for any neurological abnormalities is strongly advised. Knowing the exact cause of the swelling and numbness must be carefully examined. It could as well be due to fluid overload. In this case, modification of the dosage (increase) under special care, could be a gateway. Other causes of swelling like venous insufficiency, rheumatic diseases, possible complications of diabetes should be carefully considered. It could as well be interesting to know the recent result of your kidney function tests. An altered kidney could cause fluid overload. A proper decision or exact diagnosis would actually depend on a proper clinical review, past medical and family history and case dependent blood tests. Thanks and kind regards as I wish you the best of health. Thanks and kind regards as I wish you the best of health. DR Bain

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