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What Do MRI Findings Of White Matter Lesions Indicate?

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Posted on Thu, 30 Jul 2015
Question: Doctors have suspected MS 5 timesnin the last 15 years but foralck of MRI evidence they can't diagnose. I had an MRI because of balance problems and speach problems. Cognitive problems and a severe case of vertigo a few years ago. Had MRI with and without contrast. W/O: Punctate scatterwd subcortical white matter T2 hyperintense lesions. These are entirely nonspecific, but are most often seen in the context of chronic microvascular ischemia. The differential includes migranious change. They would be atypical for demyelination. Negative for acute infarct.
With contrast: Brain parenchyma : No diffusion signal abnormality to suggest acute infarct. Midline structures intact. Gradient imaging negative for microhemorrages. Few nonspacific punctate subcortcal T2 hyperintense white matter lesions scattered throughout the frontoparietal region bilaterally. No juxtacorical lesions. No callosal lesions. No periventricular or brainstem lesions. No cerebellar lesions. Upper cervical cord unremarkable.
I do not smoke, have diabetes, migraines or vascular disease. What could be the cause of these lesions. I had a MRI 2 years ago for suspicion of MS and there was only 1 lesion then. I have had MS symptoms for over 15 years. Ruled out Lupus, Lyme disease, and Sjogrens. I am in limbo here. Any information would be greatly appreciated. The E R doctor couldn't give a definite answer and said to followw up withh neurologist. I'm curious as to what the MRI means. Does it indicate MS, another problem or nothing at all.
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Answered by Dr. Neeraj Kumar (24 minutes later)
Brief Answer:
UNLIKELY TO BE MULTIPLE SCLEROSIS

Detailed Answer:
Hello XXXX,
I have gone through your question and understand your concerns.
Such a long history with no signs of optic neuritis, myelitis, Mri non specific finding are against the diagnosis of multiple sclerosis.
Other common reasons for white matter lacunar changes have also been evaluated.
If you are having migraine headache then it may be due to that.
You may undergo workup for vasculitic involvement.
You should also get your blood sugar, vitamin B12, homocysteine and Thyroid profile done.
Please specify what you mean by MS symptoms.
you can also upload your Mri images.
Consult a neurologist who can evaluate you and all your report properly and then evaluate you accordingly.
hope you found the answer helpful.
Do get back to me for further queries.
Regards
Dr Neeraj Kumar
Neurologist
Above answer was peer-reviewed by : Dr. Yogesh D
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Answered by
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Dr. Neeraj Kumar

Neurologist

Practicing since :2006

Answered : 2259 Questions

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What Do MRI Findings Of White Matter Lesions Indicate?

Brief Answer: UNLIKELY TO BE MULTIPLE SCLEROSIS Detailed Answer: Hello XXXX, I have gone through your question and understand your concerns. Such a long history with no signs of optic neuritis, myelitis, Mri non specific finding are against the diagnosis of multiple sclerosis. Other common reasons for white matter lacunar changes have also been evaluated. If you are having migraine headache then it may be due to that. You may undergo workup for vasculitic involvement. You should also get your blood sugar, vitamin B12, homocysteine and Thyroid profile done. Please specify what you mean by MS symptoms. you can also upload your Mri images. Consult a neurologist who can evaluate you and all your report properly and then evaluate you accordingly. hope you found the answer helpful. Do get back to me for further queries. Regards Dr Neeraj Kumar Neurologist