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What Do The Following Blood Test Reports Indicate?
Question: my latest blood work shows-A) Absolute lymphocyte count (CD45+)= 3611 REF (1000-3000) QUITE HIGH,
B)CD+ABSOLUE COUNT (T LYMPHOCYTE)=2608 (REF 600-2500) HIGH.
C)CD3+%= 72
D)CD4 CD8 RATIO= 1.07(REF. 0.7- 3.5 TOUCHING LOW END)
E)CD+8% =35 (REF 10-35 TOUCHING HIGH)
F)CD8+ ABSOLUTE COUNT T SUPPRESSOR CELLS =1265 (REF RANGE 200-1100 HIGH)
G)CD4ABSOLUTE T HELPER COUNT 1350 (REF 400-1500)
with Immunoglobulin G = 11.0,, A= 3.6,, M= 0.3,, WHERE IGM IS LOW, IGA TOUCHING HIGH RANGE,
QUANTIFERRON GOLD TB TEST IS NEGATIVE,
CATCHING INFECTIONS VERY FREQUENTLY, SINUS INFECTION. TIRED,WEAKNESS,HEADACHE, MOUTH SOURNESS,ESR high like 35,,
B)CD+ABSOLUE COUNT (T LYMPHOCYTE)=2608 (REF 600-2500) HIGH.
C)CD3+%= 72
D)CD4 CD8 RATIO= 1.07(REF. 0.7- 3.5 TOUCHING LOW END)
E)CD+8% =35 (REF 10-35 TOUCHING HIGH)
F)CD8+ ABSOLUTE COUNT T SUPPRESSOR CELLS =1265 (REF RANGE 200-1100 HIGH)
G)CD4ABSOLUTE T HELPER COUNT 1350 (REF 400-1500)
with Immunoglobulin G = 11.0,, A= 3.6,, M= 0.3,, WHERE IGM IS LOW, IGA TOUCHING HIGH RANGE,
QUANTIFERRON GOLD TB TEST IS NEGATIVE,
CATCHING INFECTIONS VERY FREQUENTLY, SINUS INFECTION. TIRED,WEAKNESS,HEADACHE, MOUTH SOURNESS,ESR high like 35,,
Brief Answer:
Lymphocytes and sub-sets are normal,TB ruled out,Ig do not suggest any ds
Detailed Answer:
Hello,
Thanks for posting your query on HealthcareMagic.
The symptoms of frequent infections especially sinus infection is suggestive of low immunity.
A high ESR suggests a chronic infectious or inflammatory process in the body.
A negative quantiferon gold TB test rules out tubercular infection or tuberculosis.
Lymphocytes are primary cells responsible for immune response of the body.
The number and percentage of lymphocytes and its sub-sets CD 4+ and CD 8+ lymphocytes are slightly raised in numbers so there is no quantitative disorder of lymphocytes.
Immunoglobulins are also responsible for maintaining good immunity in body and body surfaces.
Immunoglobulin (Ig) A is high and immunoglobulin (Ig) M is low.
Ig M is the first response to infections, however, low Ig M is also not able to explain frequent infections.
The next possibility is that of deficient complement factors.
Complement is a set of proteins in serum which gets activated during any antigen-antibody reaction in body.
Deficiency of certain members of complement family may be responsible for frequent infections.
Thus, I suggest you to get levels of complements estimated in serum.
However, you may consult your referring doctor before taking up this test.
Thanks and take care
Dr Shailja Puri
Lymphocytes and sub-sets are normal,TB ruled out,Ig do not suggest any ds
Detailed Answer:
Hello,
Thanks for posting your query on HealthcareMagic.
The symptoms of frequent infections especially sinus infection is suggestive of low immunity.
A high ESR suggests a chronic infectious or inflammatory process in the body.
A negative quantiferon gold TB test rules out tubercular infection or tuberculosis.
Lymphocytes are primary cells responsible for immune response of the body.
The number and percentage of lymphocytes and its sub-sets CD 4+ and CD 8+ lymphocytes are slightly raised in numbers so there is no quantitative disorder of lymphocytes.
Immunoglobulins are also responsible for maintaining good immunity in body and body surfaces.
Immunoglobulin (Ig) A is high and immunoglobulin (Ig) M is low.
Ig M is the first response to infections, however, low Ig M is also not able to explain frequent infections.
The next possibility is that of deficient complement factors.
Complement is a set of proteins in serum which gets activated during any antigen-antibody reaction in body.
Deficiency of certain members of complement family may be responsible for frequent infections.
Thus, I suggest you to get levels of complements estimated in serum.
However, you may consult your referring doctor before taking up this test.
Thanks and take care
Dr Shailja Puri
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
Thanks Dr.Puri,
We are also from Shimla, near CM residence, present settled in Solan now in Canada.
Got few of results from PGI which shows quite low IgM, high IgE, you can please guide what should be done as of present time. You will agree that low IgM is definite matter of concern.-
clinically- tired, getting again sinus infections,headache,shortness in breath,
We are also from Shimla, near CM residence, present settled in Solan now in Canada.
Got few of results from PGI which shows quite low IgM, high IgE, you can please guide what should be done as of present time. You will agree that low IgM is definite matter of concern.-
clinically- tired, getting again sinus infections,headache,shortness in breath,
Brief Answer:
Cause of Ig M deficiency needs to be found out.
Detailed Answer:
Hello and welcome again,
Low Ig M levels may be associated with recurrent sinus infection.
Ig M is secreted by special B- lymphocytes called plasma cells.
Selective deficiency of Ig M may be primary or secondary.
Primary Ig M deficincy is rare.
Secondary Ig M deficiency is more common and it occurs secondary to other disorders like autoimmune disorders, gastrointestinal disorders, certain malignancies, immunosuppressive drugs etc.
Thus, a comprehensive health check up is required to find out the underlying cause.
Recurrent sinus infections may be managed symptomatically but the underlying cause needs to be found out.
Complement levels may be estimated as I suggested to you previously.
Further plan of action will be determine by the test results.
Stay in touch with your referring doctor.
Thanks and take care
Dr Shailja Puri
Cause of Ig M deficiency needs to be found out.
Detailed Answer:
Hello and welcome again,
Low Ig M levels may be associated with recurrent sinus infection.
Ig M is secreted by special B- lymphocytes called plasma cells.
Selective deficiency of Ig M may be primary or secondary.
Primary Ig M deficincy is rare.
Secondary Ig M deficiency is more common and it occurs secondary to other disorders like autoimmune disorders, gastrointestinal disorders, certain malignancies, immunosuppressive drugs etc.
Thus, a comprehensive health check up is required to find out the underlying cause.
Recurrent sinus infections may be managed symptomatically but the underlying cause needs to be found out.
Complement levels may be estimated as I suggested to you previously.
Further plan of action will be determine by the test results.
Stay in touch with your referring doctor.
Thanks and take care
Dr Shailja Puri
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Thanks, can you mention tests to be done in addition to compliments, what do you think that test reports going towards blood related concerns like CLL
Brief Answer:
CLL unlikely, complement deficiency may be cause of recurrent infections.
Detailed Answer:
Hello and welcome again,
Deficiency of complement (most commonly C3) is associated with recurrent infections and thus it may be done.
CLL is a chronic leukemia which is easily picked up on routine blood investigations and confirmed by certain confirmatory tests.
Your blood report does not show any possibility of CLL.
Thanks and take care
Dr Shailja Puri
CLL unlikely, complement deficiency may be cause of recurrent infections.
Detailed Answer:
Hello and welcome again,
Deficiency of complement (most commonly C3) is associated with recurrent infections and thus it may be done.
CLL is a chronic leukemia which is easily picked up on routine blood investigations and confirmed by certain confirmatory tests.
Your blood report does not show any possibility of CLL.
Thanks and take care
Dr Shailja Puri
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Neel Kudchadkar
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