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What Does My Blood Test Report Indicate?

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Posted on Thu, 22 Jan 2015
Question: Dear Dr XXXXXXX

Following a miscarriage in July'14 (first-timer) in the first trimester, I am terribly disheartened.

My Gyn gave me a lot of strength, hope and positivity to have faith and all will be well, but I am find myself getting extremely anxious about having a successful pregnancy the next time around.

What are the chances of having a successful pregnancy following one miscarriage?

On my Gyn's advise, I underwent a blood test (Torch, ANA, Anti-phospolipid antibodies, Rubella)

Below are the findings:

ANTI-NUCLEAR ANTIBODY | Result – Positive / Moderate - Titre 1:320 (End point)
Anti­Phospholipid Antibody ­ IgG Negative (0.09)
Anti­Phospholipid Antibody ­ IgM Negative (0.16)
Anti­Cardiolipin Antibody ­ IgG Negative (0.22)
Anti­Cardiolipin Antibody ­ IgM Negative (0.15)
Random Plasma Glucose Result: 90 mg%
Toxoplasma IgG Result: Less than 5.00
Herpes II­ IgG 0.24
Herpes II­ IgM 0.4
Rubella IgG 163.0
Rubella IgM 0.51
Cytomegalo Virus­ IgG 10.9
Cytomegalo Virus­ IgM 0.24

Would like to know if there is any cause of concern? It is well over since 6 months since the mishap but I have lost faith on trying afresh. (The last time I had conceived in 2 months - period cycle length - 35 days)
Please advise on further course of action.

Thank you for your time and kind consideration.
In anticipation,
Regards,
XXXX
doctor
Answered by Dr. Aarti Abraham (49 minutes later)
Brief Answer:
MORE THAN 95 % CHANCE OF NORMAL PREGNANCY

Detailed Answer:
Dear XXXXXXX
Thank you for trusting us with your health concern.
I will be glad to assist you with this matter.
However I need a few more details.
1. THe first time round , you conceived within 2 months of trying to do so, am I right ?
2. At how many weeks of pregnancy did you have a miscarriage ?
3. Was a medical abortion done or a surgical one ?
4. Have you been trying to conceive since then ? If not, what method of contraception are you using ?
5. WHat is your height and weight ?
6. Do you have any other significant medical or personal issues ?
7. Can you upload all the test reports rather than typing me out ? This is because different labs have different ranges of what is normal and abnormal, and just typewritten values make little sense, as opposed to scanning and uploading the reports.
That said, most miscarriages occur due to random freaks of nature ( unfortunate, but reassuring ) and not due to parental disease.
They occur due to problems in the genes of the embryo as the embryo grows and divides.
Hence chances of such a mishap occuring again are pretty low actually.
About 10 to 20 percent of pregnancies end in miscarriage. The actual number is probably higher because many miscarriages occur so early in pregnancy that a woman doesn't even know yet that she's pregnant.
Miscarriage is usually a one-time occurrence. Most women who miscarry go on to have a healthy pregnancy after miscarriage. Less than 5 percent of women have two consecutive miscarriages, and only 1 percent have three or more consecutive miscarriages.
SO please take heart, I can understand what a first - time pregnancy loss must have meant to you, particularly in terms of your mental and emotional well being, but you must really and truly believe that I am not uttering mere cliches, but scientifically telling you that you would have a healthy pregnancy the next time round ( more than 95 % chance of that ).
Please upload all reports that have been done so far to investigate the cause of the miscarriage, so that I can suggest if something is amiss or something else needs to be tested for.
You are young and healthy, and it has already been 6 months since that unfortunate event.
It is time now for you to begin trying afresh with a positive attitude .
Looking forward to hearing from you.
Take care.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Aarti Abraham (14 minutes later)
Dear Dr XXXXXXX

I cannot thank you enough for your prompt response. Greatly appreciate it. Hearing from you has emboldened me to start my life afresh with a clean slate.

As requested, furnishing you with more details.

1. Yes, you got that right. My husband and I started trying from Feb'14 and I conceived in April'14 without any medications.
2. Missed miscarriage at 11 weeks.(Bicornuate Uterus in Rt.horn) (10th week scan detected fetal heartbeat, pole, yolk sac). Mine was a delayed pregnancy because my cycles have been always longer and a wee difficult to track.
3. I underwent a D&C procedure with local anesthesia.
4. Post miscarriage, I am too scared to try, so me and my partner haven't started yet. I do not use birth control pills / oral contraceptives – We have protected intercourse (with condom).
5. I am 5'5 and a half, Wt (current) – 52 kgs (I was 55 kilos in the first trimester).
6. I do not have any medical issues. Thyroid and PCOD tests were negative.
7. Apologies for typing the reports as is. I will upload the lab report shortly.

My Gyn has advised me to repeat the ANA test this month because I have no physical (significant) symptoms of any auto-immune disease. However, I am losing my mind over getting it done worrying whether this will again result in a miscarriage.

I have been regularly taking Folvite and Ecosprin. Would like to know, if taking Ecosprin will aid in my next pregnancy and help prevent clots.

Many Many Thanks for your answer. Look forward to hearing from you.

Best Regards.
doctor
Answered by Dr. Aarti Abraham (8 hours later)
Brief Answer:
ECOSPRIN IS RECOMMENDED, NEED TO LOOK AT REPORTS FOR REST.

Detailed Answer:
Thank you for the update dear XXXXXXX
As such, I cannot comment further without having a look at the reports.
Please upload the lab tests done so far, even the thyroid ones, PCOD ones, all of them - including the ones you mention as normal.
I would want to assess the situation in depth.
Regarding the ANA too, I will let you know if it needs to be repeated once I have the reports in hand.
Ecosprin is recommended for women with a previous pregnancy loss, yes it aids in conserving the pregnancy and preventing a miscarriage.
It should be continued right through the pregnancy.
Folic acid too is vital.
As I said there should be no apprehensions in trying once more, but I will reserve my definitive opinion until I go through your reports.
Looking forward to going through them.
Take care.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Aarti Abraham (8 days later)
Dear Dr. XXXXXXX

Greetings of the Day!

Further to our previous communication exchanges, I visited the Gyneac I am consulting here (in Bombay), he says, next time around when conception occurs, I may have to take low-molecular weight heparin injections or aspirin till about 7th month.

I am extremely worried about why I need to take them when I fall pregnant and is there a risk of taking them, if any. A few of my friends who have undergone previous pregnancy loss (like me - first m/c), swear by the effectiveness of this treatment and say, it is a proven line of treatment to prevent miscarriages. Is that so? I would like to know, what is the success rate of a pregnancy if I take these shots regularly?

I am very anxious about conception and fear to try again, although it is well over 6 months since that unfortunate event. Other tests for anti-cardiolipid antibodies (ACA), Anti-phospolipid antibodies were NEGATIVE.

Please advise on LMWH and whether I should start afresh.
doctor
Answered by Dr. Aarti Abraham (1 hour later)
Brief Answer:
Yes, LMWH and aspirin should be taken throughout pregnancy.

Detailed Answer:
Hello again dear .
I have gone through the ANA report.
IT is positive, but , since you have absolutely no symptoms of auto immune disease, you can actually disregard the report.
I would not see a need to repeat it , however, if your doctor wishes, you may do so.
Since all other tests were normal, you have nothing to worry about.
I would have liked to go through all test reports, even if normal, so that I would have known what all tests were done , and if there were any more I could suggest further.
One important thing is that the abortus ( aborted fetus ) should have been sent for karyotyping ( chromosomal analysis ).
That is a must - was that done ?
Regarding aspirin and low molecular weight heparin, yes, once you conceive, right from the beginning, you should take these , until atleast the third trimester.
It is a proven and scientifically recommended technique to prevent pregnancy loss.
As I said earlier, more than 90 % of women go on to have a successful pregnancy if these proper treatment steps are taken.
There is no need for any anxiety or stress, it will negatively impact your hormones and your body.
Relax, try some yoga / meditation and yes - I can clearly say - please start trying again for a child.
I am sure you would have a wonderful outcome this time.
Take care.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Aarti Abraham (3 hours later)
Thank you Dr XXXXXXX hearing from you bolsters and buoys my confidence levels.

I would also like to ask, should I continue taking Ecosprin (75 mg) and the folic acid supplement (folvite) I've been taking since the past three months.

A few questions:

1. Considering my cycles are a little longer (around 35-38 days), how can I determine ovulation and best days to chart my fertile days? Is the day - after ovulation considered fertile too?

2. How often should a couple be engaging in intercourse to maximize chances of conception?

3. How soon does the process of conception start following ovulation?

4. Since, my cycle dates vary (Nov 2' 14, Dec 7'14), how soon should a pregnancy test be done?

Thanks for your time. Look forward to your reply.

Regards,
XXXX
doctor
Answered by Dr. Aarti Abraham (1 hour later)
Brief Answer:
Answered in numerical order.

Detailed Answer:
Hi again XXXXXXX

Yes, please continue the Ecosprin and Folvite, LMWH will be started with your doctor alongwith progesterone supplementation once pregnancy is confirmed. I am answering your questions in the order in which you have asked them.

1. With irregular cycles, it is very difficult to chart fertile days. As a safe bet, you should remain sexually active from day 10 - 12 of your cycle. If the first day of bleeding is day 1, you should remain sexually active daily or every alternate day starting from day 10 - day 11 of your cycle, and continue till the next 15 days or so.
That way, you would not miss your ovulation days.
The other method is to rely on follicular monitoring ( serial ultrasound scans that track the growth of the egg follicle and can accurately target the days of ovulation ) .
However, you had no trouble conceiving the first time around , even with delayed cycles, without medications, so I anticipate no difficulty this time too.
You can try the same way you were doing the first time.
Ovulation is the release of the egg from the ovary, it remains viable for 2 - 3 days, and the sperm too is viable for upto 2 days in the genital tract of the female, so the fertile days are actually from 2 days prior to ovulation, then including the day of ovulation, and 2 days after ovulation - a period of 5 days.
And since this window is difficult to predict with delayed periods, I am suggesting sexual activity regularly from day 10 onwards.

2. Daily or alternate day during the fertile window.

3. After ovulation, the egg and sperm unite within hours, and the embryo starts developing. It implants in the uterus a week after intercourse ( fertilization ) and the earliest time to detect a pregnancy is when you miss your period.

4. Please take a pregnancy test when the longest time of your period delay has been exceeded. For example, if your cycle length is maximum 38 days, then you should take a test on cycle day 39.
Hope this has helped you.
Would be always welcoming more queries.
Wish you luck .
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Aarti Abraham (17 hours later)
Thanks a lot for your prompt response, Dr Aarti!

I would also like to know from you, what precautionary measures should be taken to prevent a miscarriage this time around? I really want to have a healthy, normal and a successful pregnancy, hence the unbridled apprehension and anxiety.

Would also like to mention, I have a bi-cornuate uterus. But my Gyn, who recently did a TVS says, there's nothing to be worried about as it is not all that bad a deviation/anomaly. Now I'm worried, if this time around, having such a uterus could pose a problem?

Please guide.
doctor
Answered by Dr. Aarti Abraham (31 minutes later)
Brief Answer:
Bicornuate uterus is fine, some pointers detailed.

Detailed Answer:
Hi again.
Well you just need to be reasonably healthy, which I assume you are !
Still some pointers for you -
1. Get all the tests done for reasons for a miscarriage. You say they are all normal, however, as stressed earlier, I would have liked to review them to know if any further tests are required. Particularly, karyotype of the aborted fetus.
2. Continue taking Ecosprin and Folic acid.
3. Start LMWH and progesterone in addition to ecosprin and folic acid as soon as a pregnancy is diagnosed.
4. Maintain an ideal BMI ( ideal weight for your height ).
5. Exercise regularly and have a nutritious diet.
5. Avoid drinking/ smoking / drugs / radiation / late nights / irregular hours / stress in personal or professional life )
6. Get in touch with a reputed Gynecologist, and get a checkup done as soon as you miss your period.
7. Remain sexually active during your fertile window.
8. Do not take any medications while you are planning to conceive, before consulting your doctor.
9. Try some yoga / mediation. Surround yourself with soothing music, refreshing photos and memories.
Regarding a bicornuate uterus, that does not lead to missed miscarriage.
It can be associated with preterm labour or less than optimum growth of the baby due to space issues, but more than 90 % of women with bicornuate uterus have a successful pregancy outcome.
Take care, XXXXXXX
Wish you lucK.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Aarti Abraham (2 days later)
Thanks for your response. Before we conclude this discussion, one last thing I would need your advice / suggestion on (this has been playing on my mind since the last week).

You said, I will have to start taking LMWH / aspirin as soon as the pregnancy is diagnosed - which is fine and I am ready to take them too. But what is worrying me is, considering I have a positive ANA, what if it comes in the way of the injections treatment and nullifies the pregnancy's success?

Please advise. Thanks.
doctor
Answered by Dr. Aarti Abraham (21 minutes later)
Brief Answer:
LMWH will only improve symptoms either ways

Detailed Answer:
Hello again.
A positive ANA in absence of any symptoms means nothing as I said.
Even if you had a positive ANA and symptoms of an auto immune disease, the treatment for the condition involves LMWH.
It will only benefit the pregnancy either ways, and improve success rate of a positive pregnancy.
Take care.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Dr. Aarti Abraham

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What Does My Blood Test Report Indicate?

Brief Answer: MORE THAN 95 % CHANCE OF NORMAL PREGNANCY Detailed Answer: Dear XXXXXXX Thank you for trusting us with your health concern. I will be glad to assist you with this matter. However I need a few more details. 1. THe first time round , you conceived within 2 months of trying to do so, am I right ? 2. At how many weeks of pregnancy did you have a miscarriage ? 3. Was a medical abortion done or a surgical one ? 4. Have you been trying to conceive since then ? If not, what method of contraception are you using ? 5. WHat is your height and weight ? 6. Do you have any other significant medical or personal issues ? 7. Can you upload all the test reports rather than typing me out ? This is because different labs have different ranges of what is normal and abnormal, and just typewritten values make little sense, as opposed to scanning and uploading the reports. That said, most miscarriages occur due to random freaks of nature ( unfortunate, but reassuring ) and not due to parental disease. They occur due to problems in the genes of the embryo as the embryo grows and divides. Hence chances of such a mishap occuring again are pretty low actually. About 10 to 20 percent of pregnancies end in miscarriage. The actual number is probably higher because many miscarriages occur so early in pregnancy that a woman doesn't even know yet that she's pregnant. Miscarriage is usually a one-time occurrence. Most women who miscarry go on to have a healthy pregnancy after miscarriage. Less than 5 percent of women have two consecutive miscarriages, and only 1 percent have three or more consecutive miscarriages. SO please take heart, I can understand what a first - time pregnancy loss must have meant to you, particularly in terms of your mental and emotional well being, but you must really and truly believe that I am not uttering mere cliches, but scientifically telling you that you would have a healthy pregnancy the next time round ( more than 95 % chance of that ). Please upload all reports that have been done so far to investigate the cause of the miscarriage, so that I can suggest if something is amiss or something else needs to be tested for. You are young and healthy, and it has already been 6 months since that unfortunate event. It is time now for you to begin trying afresh with a positive attitude . Looking forward to hearing from you. Take care.