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What Does My Lab Test Reports Indicate?

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Posted on Wed, 30 Mar 2016
Question: I've asked a question before but didn't follow up before it was closed. I have some additional questions:

- Can my thirst come from the gastric mucosal erythema and/or esophagitis, because my thirst is better when I drink full fat milk, but gets a lot worse when I don't?

- Can it be due to some fungal/bacterial overgrowth in the gut? When I drink more milk my tongue can get a bit sore in the middle and there's slight depapilation that gets better when I do coconut oil rinses and abstain from milk.

Here's what I wrote before and the doctors answer:


7 months ago I was at the hospital because I had a slightly strange EKG and elevated creatine kinase levels (I was working out a lot). They have now found out I have a bicuspid heart valve with a discrete insufficiency. Nothing I noticed before.



I was in the hospital for 3 days and got some blood thinners. Then I was told to take some baby aspirin. After 3 weeks on that I suddenly became very out of breath. I got pain in my chest and couldn't train anymore. I continued with the aspirin for another week and started getting pain in my lower back and dizziness. After stopping the aspirin, the lower back pain went away, but I started feeling extremely thirsty, waking up every hour to drink. The blood samples at the emergency didn't show anything. The thirst persisted. It got better when drinking full fat milk. If I stopped the milk it would start again stronger.



At the same time many of my veins have gotten more swollen and visible. The smaller ones are also more visible. Especially around the feet. I also got toe nail fungus on all nails and it all happened in a very short time while this was going on... maybe 2-3 months.



I had an endoscopy 2 months ago because I had some stomach and solar plexus discomfort on and off for the past year or so. The endoscopy showed



- esophagitis, class A Los Angeles

- small hiatal hernia

- gastric mucosal erythema



I also took a bunch of blood tests (see attached PDF). It showed slight hypochloremia and various other things that were slightly off. E.g. high renin, high urinary cortisol, and various other electrolytes.



If it were something with the stomach, why would this state persist? I stopped taking the aspirin 5 months ago.



Maybe I am allergic to aspirin?





Doctor's reply to your question above...
Brief Answer:
I would explain as follows:

Detailed Answer:
Hello,

Welcome on HCM!

I passed through your medical history and uploaded tests and could explain that the reason why you are experiencing those uncommon symptoms (excess thirst, chest discomfort, shortness of breath, dizziness, etc.) are primary related to high cholesterol and plasma renin levels.

All the other lab findings are consequence of the above hormonal imbalances.

With this I mean increased urine electrolyte levels [potassium, magnesium and chloride] caused by elevated absorption of sodium and water by the kidneys and also increased excretion of the other ions, mediated by increased cortisol levels.

These effects, coupled with increased plasma renin activity lead to increased blood pressure values, which may be responsible for some of your complaints (chest discomfort, shortness of breathing, edema, etc.).

But the main issue to be considered is finding the responsible cause of high renin and cortisol levels.

Coming to this point, several reasons maybe implicated such as:

- Adrenal gland hyperplasia or tumor(s),
- liver & renal dysfunction, such as nephrotic syndrome, etc.

Pain located to lower back and decreased 25 (OH) Vit D3 increase suspicions on adrenal/renal processes.

Also, other extra-renal or -adrenal processes may be responsible for such hormone imbalances.

I recommend consulting with an internist or endocrinologist for a comprehensive differential diagnosis of your actual hormonal imbalance, also investigating for the presence of possible diabetes and hypertension.

Additional abdominal imagine studies (ECHO, CT, MRI, etc) may be necessary to identify possible structural disorders.

You should discuss with your attending doctor on the above mentioned issues.

Hope to have been helpful to you.

In case of further uncertainties, feel free to ask me again.

Kind regards,

Dr. Iliri
Replied by Dr. Ilir Sharka , 5 days ago

doctor
Answered by Dr. Prof. Kunal Saha (2 hours later)
Brief Answer:
Reflux seems to be the cause. Milk neutralizes acid and relieves thirst

Detailed Answer:
Thanks for asking on HealthcareMagic and thanks for taking the pains to summarize the entire details in one thread. I have gone through the entire details patiently and am eager to help you.

A lot of unnecessary tests have been done. However, I would link your increased thirst to the mild hypochloremia. It is otherwise insignificant but is usually associated with low sodium levels (even though the reports do not reflect the same) which in turn is associated with increased thirst. Gastroesophageal reflux is another reason contributing to it. It is possible that the milk was actually supplementing the electrolyte deficiency that was occurring. I would suggest you to try taking ORS (oral rehydration solution) and see if it does the same. Another possibility is that milk is alkaline and therby neutralizing the acid that is refluxing or regurgitating back and the neutralization of this acid (the effect of reflux) is actually providing relief from the thirst.

I would insist you to take small but frequent meals. That should help in dealing with the reflux esophagitis You may take prilosec (omeprazole) once daily before meals.

I do not think that aspirin allergy has anything to do with all these. Neither do I think that overgrowth of bacteria or fungus anywhere is contributory.

Let me know if I could help further.

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Prof. Kunal Saha (3 hours later)
Hello

Thank you very much for your detailed answer. It makes sense that there should be some electrolyte disturbance. I'll try to look ORS up and take an anti-acid.

There's one more mystery that I haven't found the answer to, and I'll appreciate any help or theory. It's the swollen veins and spider veins that developed during this period. I've been trying to find out what to do about them. They're very distressing because they came over the course of a few months while all this happened.

When I had the endoscopy the doctor said I had very visible small veins in my upper esophagus. So it must be systemic. I developed lots of small spider veins on my feet and very visible larger veins - they're almost blue after I stand up and wear warm shoes for a while, and also bigger veins on my lower arms and hands.

At the same time all my toe nails started peeling off (fungus). Maybe due to inadequate blood supply? (I've uploaded a few (scary) images)

It's all connected somehow to the thirst and aspirin which then maybe are connected to my stomach issues?

Could the stomach problems lead to bad circulation? Maybe blood clotting in my capillaries? The reason I'm thinking this is that 7 months ago, they thought I had a small clot in my heart when they looked at my EKG, that's why they gave me the aspirin. And a few months later there was a small change in the EKG according to one cardiologist, as if there could have been a clot. But because of all these symptoms and the painful reaction I get to Aspirin now I don't dare take it.

Another reason I'm bringing this up is that once during this time I went blind on the lower half of my right eye for about 3 minutes. It was suddenly completely grey, and then it was gone and I could see again.

I'm not a doctor, but I'm trying to understand what is going on. Are any of the following theories plausible:
- the thirst caused the body to shut off blood supply to extremities causing more pressure on the medium and larger veins causing some sort of adaptive expansion, maybe due to the high renin (decreased blood flow to the kidneys or due to the electrolyte imbalance), or
- gastric irritation caused an increase in something like Serotonin, making platelets clump together more easily blocking blood flow through many small capillaries causing tissue hypoxia

I also got a lot of white hair during the past 4-5 months, so apparently blood flow there is also impaired.

Thank you.


Just a few more theories and questions that have been running through my head trying to understand my veins:

- I had an ultrasound done too. The doctor wrote that my vena cava is 2.4cm in diameter. Is that normal or is it dilated?
- can the 3x normal renin cause vasodilation?
- is renin high because of electrolyte problems, or because the kidneys don't get sufficient blood flow, maybe from some small clot that moved, e.g. from my legs to somewhere near the kidneys?
- when I was at the hospital 7 months ago, they gave me some blood thinners for a few days, while the creatine kinase fell, which they later attributed to exercise. Could that have started something with the veins?
- the guy next to me at the hospital got a systemic fungus infection I was with him in the room for a day. Because of this nail fungus, could I have some internal fungal infection going on that affects blood vessels?


I found online that the clot around kidneys is called: Renal vein thrombosis. Is that a possibility?

Wrt. renal vein thrombosis, I did have lower back pain after taking the aspirin for a while. It started with a pulsing pressure pain in the right kidney area that moved down to the lower back. After I stopped the aspirin it went away. A few weeks later I had the eye blindness experience, after which I took the baby aspirin again for 3-4 days, but stopped it again because the kidney pain started again and I suddenly got extremely dizzy and felt as if I was getting palpitations. And then the thirst started. The lower back pain was gone 1 week after stopping the aspirin and the dizziness a few weeks later. But the thirst persisted, and with it came the progressively larger veins and spider veins.

Sorry for the overwhelming amount of information. My mind just keeps searching for a resolution to the problems by scanning through all the evidence. But it's difficult to know which is relevant and which not.

Thank you.
doctor
Answered by Dr. Prof. Kunal Saha (24 hours later)
Brief Answer:
Stop panicking is all I would say.

Detailed Answer:
Thanks for writing back. Sorry for being away and not being able to respond faster. It is good that you are trying to understand what is going on with your body but I would strongly insist you not to grow apprehensive.

I have checked the attached images.
- The prominent veins on your upper and lower limbs look perfectly normal to me and are not a cause for concern. It is only if varicosities appear on the lower limbs (occurs due to incompetence of venous valves but not otherwise) that you need to be concerned. In such a case you would need a venous Doppler study to be done but it does not seem to be such a thing at present.
- The vena cava is dilated and the normal size is usually around 15 to 17 mm.
- Renin leads to expansion of the blood volume. Increase in renin would thus lead to increased blood volume and that explains the engorgement of the veins. An echocardiography will reveal if the heart is getting overloaded. If not, it is not a cause for concern.
- I do not find a correlation with the creatine kinase issue.
- Renin level is likely to have increased due to the renal vein thrombosis. That is why the blood thinners are needed (to take care of such thrombosis and prevent one from recurring).
- Nail fungus would not manifest with fungus in your blood stream. Nail fungus are pretty common and treatment with topical antifungals like clotrimazole lotion along with oral antifungals like fluconazole should resolve the situation.
- The guy next to you might not be the only possible source of fungus. Such fungi are all around us. We cannot always see them with naked eyes.
- Stomach problems would not lead to bad circulation. Gastric irritation would not make platelets clump together so long as there is no active bleeding.
- You need not bother with your circulation. Unless another thrombosis occurs, your circulation should be just fine.

Last but not the least
- Unless you resolve your panic and wandering around medical facts aimlessly trying to link every possible thing that has a possibility of going wrong, your health would get worse. Take some anxiolytic if needed.

Let me know if I have missed anything else and surely I shall comply.

Regards
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Prof. Kunal Saha (14 hours later)
Thank you for the time you've taken to answer my questions.

I've made an appointment with a psychiatrist in a few weeks just in case.

I did not get any definitive blood clot or thrombosis diagnosis to explain the elevated renin and thirst. Only that there could have been one in the heart at some point and the 5 minute one-eyed transient blindness I experiences. So if there is a slight impediment in blood flow to one of the kidneys, it's not something that has been diagnosed.

It does preoccupy me because it just doesn't go away. The thirst keeps recurring regularly and the veins do not return to normal. Maybe because I studied bioinformatics I'm also interested in finding a biological explanation to what exactly is happening and why.

I have just a few follow up questions, if you don't mind, and then I'll try to leave it at that for now.

1. A (not very detailed) MR scan of my body, including kidneys, showed bilateral "pyelocaliceal ectasia". Is that something that can disturb the renin producing system?

2. Or, if the stomach is responsible for causing thirst, wouldn't renin go up when I feel the thirst, causing all the vascular changes and reduced blood flow to the periphery?

3. Is it plausible for the tone of the veins to decrease or their diameter to increase due to local pressure and high renin (and aldosterone)? Some of the more dilated veins in my left arm became larger after I occluded circulation through them when I had a wrist band and when I had part of the hand pressing against my pocket for 5-10 minutes. The all became even wider in my arms when I had the blood pressure cuff on a few times during times of excessive thirst symptoms. After such instances of temporary pooling and increased pressure in the veins, it seems like the affected large veins have re-adjusted their diameter set points upward. The dilations also seem to be correlated to days where I consumed lots of carbohydrates. Maybe because carbs bind water leading to temporarily less blood volume which the kidneys don't respond to properly?

4. If I can get the renin down, then maybe the veins might have a chance to re-adjust, and the thirst might go away? I've just started taking some natural blood thinners (nattokinase, serrapeptase, vitamin E), as I do think the aspirin did something strange with me. The kidney pain came while I was taking it and went away when I sopped.


Thank you.

Regards,
XXXXX


Forgot one more:

5. I've had muscle tiredness in my arms often when it's cold and sometimes in my neck muscles. Could that be from impaired absorption of certain vitamins due to my stomach issues, like e.g. B12 and Calcium? That's one of the other reasons I'm a bit concerned about taking an anti-acid (PPI), as I've read they both require acid for absorption.
doctor
Answered by Dr. Prof. Kunal Saha (36 minutes later)
Brief Answer:
Questions answered sequentially

Detailed Answer:
Thanks again for writing back.

1. I do not think that an MRI of your whole body will provide anything concrete. Investigations can back up only something that we are suspecting definitively. No specific findings are expected in this case. Hence there is no meaning for getting the same done.
2. Stomach is not likely to be the cause of your thirst. I have already explained hte possible mechanism of your thirst. Stomach will not make the blood go to the periphery.
3. I do not think that you are explaining it correctly. Application of the wrist band occluded the venous return and made the veins engorged. After the occlusion was removed, the veins returned to their normal situation. In case of the vena cava, it is engorged as the total blood volume is increased on effect of rennin and the vena cava has to dilate to accommodate it. But that does not make the reverse true. Veins are not very muscular structures and hence they cannot contract to decrease (from normal) their diameter to increase the local blood pressure.
4. I do not find a connection of the thirst with the veins, venous pressure or blood thinners. Hence there is nothing to say about this.
5. The fatigue in neck muscles is unlikely to be due to impaired absorption of vitamins from the stomach. PPIs are unrelated.

Regards
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Above answer was peer-reviewed by : Dr. Yogesh D
doctor
Answered by
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Dr. Prof. Kunal Saha

General & Family Physician

Practicing since :1954

Answered : 4467 Questions

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What Does My Lab Test Reports Indicate?

Brief Answer: Reflux seems to be the cause. Milk neutralizes acid and relieves thirst Detailed Answer: Thanks for asking on HealthcareMagic and thanks for taking the pains to summarize the entire details in one thread. I have gone through the entire details patiently and am eager to help you. A lot of unnecessary tests have been done. However, I would link your increased thirst to the mild hypochloremia. It is otherwise insignificant but is usually associated with low sodium levels (even though the reports do not reflect the same) which in turn is associated with increased thirst. Gastroesophageal reflux is another reason contributing to it. It is possible that the milk was actually supplementing the electrolyte deficiency that was occurring. I would suggest you to try taking ORS (oral rehydration solution) and see if it does the same. Another possibility is that milk is alkaline and therby neutralizing the acid that is refluxing or regurgitating back and the neutralization of this acid (the effect of reflux) is actually providing relief from the thirst. I would insist you to take small but frequent meals. That should help in dealing with the reflux esophagitis You may take prilosec (omeprazole) once daily before meals. I do not think that aspirin allergy has anything to do with all these. Neither do I think that overgrowth of bacteria or fungus anywhere is contributory. Let me know if I could help further. Regards