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What Does This Pap Smear Test Report Indicate?

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Posted on Wed, 18 May 2016
Question: Hi,
my wife's routine pap smear test states:"Smear shows superficial squamous cells, intermediate squamous cells and a few parabasal cells. Occasional intermediate cells are pleomorphic, show reverse N:C ratio and hyperchromatic nucleus with prominent nucleoli. Endocervical cells are seen in clusters. Background shows dense neutrophils along with occasional histiocytes. No dysplatic cells are seen."

Impression: "High grade squamous Intraepithelial Lesion (HSIL)

What does that mean?
doctor
Answered by Dr. Richa Agarwal (1 hour later)
Brief Answer:
Means carcinoma in situ.

Detailed Answer:
Hello dear,
Thanks for trusting hcm about your health care.
I have gone through your history and understand your concerns.
HSIL( high grade squamous intraepithelial lesion) indicates moderate or severe intraepithelial lesions or carcinoma in situ.
But it does not mean that you are suffering from cervical cancer, there is only 2% chance of it to convert to cervical cancer if not treated early.
Your doctors opinion is right to go for colposcopy and biopsy to remove the affected area.
LEEP (Loop Electrosurgical Excision Procedure) is the treatment of choice.
Hope you found this useful, feel free to discuss more information.
Good luck.
Regards
Above answer was peer-reviewed by : Dr. Sonia Raina
doctor
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Follow up: Dr. Richa Agarwal (22 hours later)
She had similar Pap Smear test done on Feb 2011. The report is below:

"Cytological Description: The smear shows superficial and intermediate cells and honeycombs of endocervical cells. No evidence of viral cytopathia noted. No atypical cells including dyskaryotic or malignant cells evident. No pathogens seen.

Interpretation/result: Negative for intra-epithelial lesion or malignancy."

BTY what is intra-epithelial lesion? How it is determined? Just out of curiosity.
doctor
Answered by Dr. Richa Agarwal (10 hours later)
Brief Answer:
Abnormal growth of epithelial cells.

Detailed Answer:
Hello dear,
Sorry for the delay in my response.
Intraepithelial lesions means abnormal growth of epithelial cells (called squamous cells) on the cervical which may lead to cervical cancer.
So in her case that report was normal and not showing any intraepithelial lesions.
Hope found useful, feel free to ask more information.
Good luck.
Regards
Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Richa Agarwal

OB & GYN Specialist

Practicing since :1999

Answered : 4031 Questions

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What Does This Pap Smear Test Report Indicate?

Brief Answer: Means carcinoma in situ. Detailed Answer: Hello dear, Thanks for trusting hcm about your health care. I have gone through your history and understand your concerns. HSIL( high grade squamous intraepithelial lesion) indicates moderate or severe intraepithelial lesions or carcinoma in situ. But it does not mean that you are suffering from cervical cancer, there is only 2% chance of it to convert to cervical cancer if not treated early. Your doctors opinion is right to go for colposcopy and biopsy to remove the affected area. LEEP (Loop Electrosurgical Excision Procedure) is the treatment of choice. Hope you found this useful, feel free to discuss more information. Good luck. Regards