Brief Answer: clonidine Detailed Answer: Hi, Thanks for your query. The most commonly used drug in methadone withdrawal is clonidine. It is generally safe to use if you don't have any blood pressure problems, and it reduces the agitation, palpitations, and anxiety. Other anti anxiety medications like diazepam can help as well, but clonidine is more commonly used. Other options include slower tapering off of the methadone, using anesthetics to induce sleep, or subutex. All of these options require medical supervision, so make sure to do them with your doctor and discuss what is right fr you. I wish you the best of luck in getting off the methadone. You should be proud of yourself for what you are doing, it is not easy and takes a lot of courage. Keep up the good work! I hope this was helpful, if you have any more questions, please let me know.

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