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What Is R1 Dilation Regarding Secondary Syphilis?
Posted on
Mon, 26 May 2014
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Mon, 26 May 2014
Answered on
Sat, 21 Jun 2014
Last reviewed on
Question : My maid detected with secondary syphilis. Undergone 10 days monocef 1 gm iv and 14 days minoz.tpha was 1:640. After year tested positive for vdrl at R1 solution and tpha 1:160. Doctors asking to take peniciline for seronegative, but assuring that he is cured. Kindly give your veiw. What is r1 dilition
, tpha value showing improvement and he is fully cured or not
, tpha value showing improvement and he is fully cured or not
Brief Answer:
Seronegativity not an indicator; azithromycin best
Detailed Answer:
Hi there XXXXXX.
I understand your concerns & empathise.
Your maid is in the clear & no further tests or treatment required.
Seronegativity is often never achieved & if there is a 2-4 fold drop in titre (as it is in your case), you may consider the treatment as being effective.
R1 dilution is a difficult concept to understand & involves an entitiy called a 'prozone phenomenon' that occurs in these serology reactions' ...do not sweat over this..it suffices that it was done & the lab appears competent.
As I said, no further treatment is required but for peace of mind, please do take a 15 day course of Azithromycin 1 gram tab taken twice/day for 15 days & close the chapter. Remember to impress upon him the virtues of safe sex & do hope his partner/s have been treated to prevent recurrences.
Good Luck & trust all your queries have been suitably addressed & he does appear well on the road to recovery if not totally cured. Cheers.
Dr Praveen Rodrigues MD
Seronegativity not an indicator; azithromycin best
Detailed Answer:
Hi there XXXXXX.
I understand your concerns & empathise.
Your maid is in the clear & no further tests or treatment required.
Seronegativity is often never achieved & if there is a 2-4 fold drop in titre (as it is in your case), you may consider the treatment as being effective.
R1 dilution is a difficult concept to understand & involves an entitiy called a 'prozone phenomenon' that occurs in these serology reactions' ...do not sweat over this..it suffices that it was done & the lab appears competent.
As I said, no further treatment is required but for peace of mind, please do take a 15 day course of Azithromycin 1 gram tab taken twice/day for 15 days & close the chapter. Remember to impress upon him the virtues of safe sex & do hope his partner/s have been treated to prevent recurrences.
Good Luck & trust all your queries have been suitably addressed & he does appear well on the road to recovery if not totally cured. Cheers.
Dr Praveen Rodrigues MD
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Thnx doc.....This was valuable and very helpful information. I will educate him for the above matter so that no further suffering to others happens.
Brief Answer:
Cheers
Detailed Answer:
Good Luck & Wish you all the best. It appears you are a good employer & a humane, rationale & considerate person.
Best wishes.
Dr Praveen Rodrigues MD
Cheers
Detailed Answer:
Good Luck & Wish you all the best. It appears you are a good employer & a humane, rationale & considerate person.
Best wishes.
Dr Praveen Rodrigues MD
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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