What Is Mitochondrial Dysfunction In Parkinson's Disease?

Posted on Wed, 27 Jul 2016

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Wed, 27 Jul 2016 Answered on

Tue, 23 Aug 2016 Last reviewed on

Question : What is mitochondrial Parkinson's?

Answered by Dr. Dr. Erion Spaho (3 hours later)

Brief Answer:
Mitochondrial processes affected by different substances.

Detailed Answer:
Hello and thanks for using HCM.

I have read your question and understand your concerns.

Mitochondrial Parkinson's disease refers to Parkinson's disease that may be caused by substances that affect mitochondrial processes such MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

MPP accumulates in mitochondria and interferes with the function of complex I of the respiratory chain. A chemical resemblance between MPTP and some herbicides and pesticides suggested that an MPTP-like environmental toxin might be a cause of Parkinson disease, but no specific agent has been identified. Nonetheless, mitochondrial complex I activity is reduced in Parkinson disease, suggesting a common pathway with MPTP-induced parkinsonism.

Hope you found the answer helpful.

Let me know if I can assist you further.

Greetings.

Above answer was peer-reviewed by : Dr. Priyanka G Raj