What Is The Expected Anti-rabies Neutralizing Antibody Titre Value Post Vaccination?

Posted on Fri, 21 Aug 2015

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Fri, 21 Aug 2015 Answered on

Fri, 11 Sep 2015 Last reviewed on

Question : What will be the expected antibody totre value of rabies shot taken on 0 3 7 of first three vaccine?and why vetnarian are asked to have booster dose after 1 year even they are exposed to saliva and scratches regularly of various animals?

Answered by Dr. Vivek Chail (24 minutes later)

Brief Answer:
Antibody level will be above 0.5 IU/ ml after 0, 3, 7 rabies vaccine

Detailed Answer:
Hi XXXXX,
Thanks for writing in to us.

I have read through your query in detail.
Please find my observations below.

1. As per health policies, anti rabies neutralizing antibody titre of 0.5 IU/ ml or more in serum is considered safe and protective.

2. The above antibody level is reached at about 30 days from the start of vaccination in a 0, 3, 7 vaccination schedule.

3. After 1 year the booster is given to maintain antibody level above 0.5 IU/ ml for adequate protection.

Please feel free to correct any oversight in my interpretation of your problems and discuss them in detail as per your requirements.

Hope your query is answered.
Do write back if you have any doubts.

Regards,
Dr.Vivek

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Vivek Chail (7 minutes later)

Sir after 0 3 7 vaccine is it possible that antibody level have high value then 0.5?or its remain only 0.5?

Answered by Dr. Vivek Chail (5 minutes later)

Brief Answer:
The antibody level will be higher than 0.5 IU/ ml after 0, 3, 7 vaccination

Detailed Answer:
Hi XXXXX,
Thanks for writing back with an update.

1. The lower limit is 0.5 IU/ ml after 0, 3, 7 vaccination and it is always higher than that. All clinical trials have shown that the antibody level will surely be above 0.5 IU/ ml following the 0, 3, 7 vaccination dose schedule for rabies.

Hope your query is answered.
Do write back if you have any doubts.

Regards,
Dr.Vivek

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Vivek Chail (1 hour later)

Sir my last question for u what does that mean pre exposure provide immunity for 1 year?its provide immunity for future for what purposes?thanking u

Answered by Dr. Vivek Chail (9 hours later)

Brief Answer:
Pre exposure immunity means you are already protected

Detailed Answer:
Hi XXXX,
Thanks for writing back with an update.

1. Pre exposure immunity means that you are protected from rabies before hand. If you have a dog bite after taking pre exposure vaccination then the antibody levels are already above 0.5 IU/ ml and you are protected and taking booster with enhance your immunity.

Hope your query is answered.
Do write back if you have any doubts.

Regards,
Dr.Vivek

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Above answer was peer-reviewed by : Dr. Vinay Bhardwaj