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What Is The Window Period Of 3rd Generation Antibody Test?

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Posted on Tue, 23 Dec 2014
Question: window period of 3rd generation antibody test? I tested HIV after 18 weeks of exposure? It was 3rd generation test using VITROS ECi. Result was negative. Is it conclusive? Or I need further test? Can HIV spread through deep throat kissing?
doctor
Answered by Dr. Matin Ahmad Khan (1 hour later)
Brief Answer:
Yes it is conclusive

Detailed Answer:
Thanks for your question . I am Dr Matin, answering your queries.
Third-generation tests detect all types of antibodies, which makes them more sensitive than the first-generation and second-generation tests.
These assays can detect antibodies about 21-24 days after infection .
VITROS ECi being a third generation test, has a window period of 21-24 days and your negative test report @18 weeks, makes it conclusive about your negative status. I guess no further tests warranted.

The probability of HIV transmission through oral route including deep throat kissing is minimal, though it is not zero, because there could be many variables in this scenario, but it is very minimal for sure.

Hope it helps.
http://bit.ly/askdrmatinahmedkhan
Above answer was peer-reviewed by : Dr. Ashwin Bhandari
doctor
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Follow up: Dr. Matin Ahmad Khan (16 minutes later)
How many cases appeared in XXXXXXX of HIV infection by deep kissing?
CDC reported one long back, where there were huge bleeding gums of both partners.
doctor
Answered by Dr. Matin Ahmad Khan (17 minutes later)
Brief Answer:
No cases as far I know in XXXXXXX

Detailed Answer:
Thanks for your response.
I am not aware of any such case in XXXXXXX ,spread through this mode .
Hope this helps.

Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Matin Ahmad Khan (16 minutes later)
Vitro Eci is it a modern antibody test?
Why NACO is saying 6 months test is conclusive?
doctor
Answered by Dr. Matin Ahmad Khan (12 minutes later)
Brief Answer:
Program management contraints

Detailed Answer:
Thanks for your response.
Many constraints including finances have to be taken into account for running a welfare programs like NACP(National AIDS Control Program).
What NACO does for testing ,is not done in private set ups too.. Here (NACO) three simultaneous tests are run (Antibody tests) on single blood sample and if all three tests become positive , then only a positive result is report.
Hope this helps.
Regards

Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Matin Ahmad Khan (1 hour later)
There fore the conclusion is if antibody test done from private more modernized lab after 90 days period it will be considered final. AM I RIGHT?

Vitro Eci is it a modern antibody test?
doctor
Answered by Dr. Matin Ahmad Khan (9 hours later)
Brief Answer:
Both conclusive

Detailed Answer:
Thanks for your response.
Both are conclusive , as modern labs are doing even 4th Generations tests which determines both antigen and antibody but the protocol -the frequency of tests remains the same .
In Govt set up they are doing antibody tests only and so increase the sensitivity and match with newer tests (ability to pick up positive ones) they run three antibody tests with the same sample so as to increase the chances of picking up the positive samples.
By the way if somebody has already crossed the 'window period' and then does the tests ,which come negative , then there is no point for him/her to go for further tests.
Hope it helps.
Regards

Above answer was peer-reviewed by : Dr. Yogesh D
doctor
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Follow up: Dr. Matin Ahmad Khan (3 hours later)
I heard that windows period changed from 2004. Before it was officially 6 months. Vitros ECIi is it a latest antibody test?
doctor
Answered by Dr. Matin Ahmad Khan (48 minutes later)
Brief Answer:
window period does not matter in your case

Detailed Answer:
Thanks for your response.
I understand,window period does not matter in your case.
ECi is a third generation test and determines the antibody .
4th Generation tests determine both antigen and antibody both. Antibody is common.
I guess , we have some fruitful discussion about 'window period' and wind up here.
Regards
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Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
Answered by
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Dr. Matin Ahmad Khan

HIV AIDS Specialist

Practicing since :1987

Answered : 298 Questions

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What Is The Window Period Of 3rd Generation Antibody Test?

Brief Answer: Yes it is conclusive Detailed Answer: Thanks for your question . I am Dr Matin, answering your queries. Third-generation tests detect all types of antibodies, which makes them more sensitive than the first-generation and second-generation tests. These assays can detect antibodies about 21-24 days after infection . VITROS ECi being a third generation test, has a window period of 21-24 days and your negative test report @18 weeks, makes it conclusive about your negative status. I guess no further tests warranted. The probability of HIV transmission through oral route including deep throat kissing is minimal, though it is not zero, because there could be many variables in this scenario, but it is very minimal for sure. Hope it helps. http://bit.ly/askdrmatinahmedkhan