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Hello ! I Have Question Does CHLAMYDIA TRACHOMATIS INFECTION A

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Posted on Thu, 23 Jun 2022
Question: hello !

I have question does CHLAMYDIA TRACHOMATIS INFECTION A TRIGGER FOR LUPUS ERYTHEMATOSUS ?

Or risk is very small for CHLAMYDIA TRACHOMATIS develop - Systemic Lupus Erythematosus

There is only one study - and it is no serious - if there would be such association there should be lot of such publications !

The question does CHLAMYDIA TRACHOMATIS lead to CHLAMYDIA TRACHOMATIS ? ( or risk is very small - and low association - as there is only one study what i found !

https://www.researchgate.net/publication/0000_IS_CHLAMYDIA_TRACHOMATIS_INFECTION_A_TRIGGER_FOR_LUPUS_ERYTHEMATOSUS_MPS_Sawhney_VP_Chaturvedi_S_Arora

Twenty three (88.46%) of the cases were females and three (11.54%) were males with an average age of 31.23 years (SD 4.33 years). Forty one (87.23%) and 6 (12.77%) of controls were females and males respectively with an average age of 30.14 years (SD 3.35 years). The difference in mean ages between cases and controls was not found significant (P> 0.05). Eight (30.77%) cases and 3 (6.38%) controls tested positive for C. trachomatis antibodies. This difference was found statistically significant (2 df = 1 P < 0.01 with Odds ratio of 6.62, there is 5.0 to 43.2% higher chance of developing SLE in patients with seropositivity for C. trachomatis

2. Questing - in this study it is said that

While seeing cases of SLE, we noticed that many of them had associated pelvic inflammatory disease (PID). Since Chlamydia trachomatis is one of the most common causes of PID and it is known to initiate HSP-60 induced CD8+ T-cell mediated cytotoxicity by molecular mimicry in Reiter’s disease, we decided to look for evidence of C. trachomatis infection in patients of SLE.

And again - does SLE is causes by pelvic inflammatory disease or its is associated with that SLE patients have lower immunity and they are more likely to get pelvic inflammatory disease from some pathogens like Gardnerella vaginalis not C. trachomatis

Thank you very much !
doctor
Answered by Dr. Sankaranantham Murugan (19 hours later)
Brief Answer:
SLE triggered by Chlamydia Infection is remote possibility or a coincidence

Detailed Answer:
Hi,
Welcome to ASK A DOCTOR through HCM.
Thanks for posting your query.
Nearly 4 million cases of chlamydial infections per annum are reported in US alone. Imagine the load of infections across the whole world.
SLE is known entity and autoimmune disorder widely prevalent worldwide. It can be triggered through various drugs and diseases. But I had come across a single case triggered by chlamydial infection or suspected to be so far in my 45 years of experience.
Reiter's disease is the one established to be triggered by Chlamydia Trachomatis nongonococcal infection.
Medicine is not mathematics to get a constant answer. Possibility of chlamydia triggering SLE cannot be ruled out.
Dr S.Murugan
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sankaranantham Murugan (5 hours later)
Thank you very much !

1. Yes - your ar right as from literature what i read Chlamydia Infection is not associated with SLE
As you said it could be but it is very rare as also https://emedicine.medscape.com/ has not described Chlamydia Infection association with SLE and other study said that if SLE woman get Chlamydia Infection they ar not more likely to get endocervical infection than others

The prevalence of endocervical CT infection in women with
SLE is low and similar to that of the normal population.

https://sci-hub.se/10.1007/s00296-012-2419-z

so in conclusion CHLAMYDIA TRACHOMATIS is no associated wit SLE or risk is very low !


2. drug-induced lupus is associated with some drugs - and if drugs are stooped in early when symptoms start there is no risk of organ damage ! and if drugs stopped drug-induced lupus is going away - and you gone recovery - as i read from literature !

3. Some STS in males can cause Infertility -
like Gonorrhea and Syphilis can cause permanent scarring and blockages in the sperm production cycle leading to male infertility

But if it is treated in time it will not cause any permanent infertility ?

So if symptoms starts - and you get treated soon as possible it will not cause permanent infertility !
Is it so ?

as for example CDC it is said :

Men rarely have health problems from chlamydia. The infection can cause a fever and pain in the tubes attached to the testicles. This can, in rare cases, lead to infertility.
https://www.cdc.gov/std/chlamydia/stdfact-chlamydia.htm


Does asymptomatic STS cause permanent infertility - as i understand from literature no - asymptomatic STS infertility could be treated by antibiotics.

Thank you very much
doctor
Answered by Dr. Sankaranantham Murugan (18 hours later)
Brief Answer:
Asymptomatic infection also may lead to permanent damage

Detailed Answer:
Hi vismuss,
welcome back.
First of all I congratulate you that you had analyzed the subject very well and understood the same.
1. True
2. Once the SLE triggered either with drug or infection, it will run a chronic course. But if the drug stopped earlier the progress of the SLE may be slower. Moreover the progress of the disease often goes as per the individual's immune response and may differ from person to person.
3. Early recognition of STIs and its management will definitely alleviate severe complications. No Doubt.
At the same time, partially treated or inadequately treated Reproductive tract infections and STIs, becomes asymptomatic, but can go for permanent complications, damage and infertility.
Dr S. Murugan
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sankaranantham Murugan (28 hours later)
Hello !

Than you for your answers

1. By this answer you made huge mistake

Once the SLE triggered either with drug or infection, it will run a chronic course.

in all literature it is said that Drug Induced Lupus it is reversible


Drug-induced lupus can be life-threatening, but it's completely reversible once you stop taking the drug that's to blame.

https://www.verywellhealth.com/drug-induced-lupus-0000

How long will drug-induced lupus continue?
The lupus-like symptoms usually disappear within six months after these medications are stopped.

https://www.verywellhealth.com/drug-induced-lupus-0000



2. Question in your field

in on study it was said Chlamydia trachomatis and Chlamydia pneumoniae could cause reactive arthritis

There was one study - but it was very bad study - with wrong conclusions like if you treat Chlamydia pneumoniae it could prevent Chlamydia trachomatis and so on ( Chlamydia pneumoniae can no be cured)

From the study:
The prevention or treatment of C. pneumoniae infection can prevent
infection by C. trachomatis inducing ReA, infertile, and visual impairment by trachoma.

https://www.longdom.org/open-access-pdfs/patients-with-prior-infection-by-chlamydia-pneumoniae-are-vulnerable-to-infection-by-chlamydia-trachomatisserum-iga-anti.pdf

In this study there where lot of mistakes - and by such conclusion i understand that is wrong study

So the question C. pneumoniae is not a risk factor for reactive arthritis for Chlamydia trachomatis !
As lot of people 80% get C. pneumoniae during their life and it is not like that thous who have C. pneumoniae and get Chlamydia trachomatis will get reactive arthritis.
So we can not say that C. pneumoniae is riks factor in reactive arthritis in Chlamydia trachomatis patients, but some times it could go together

https://sci-hub.se/10.2298/mpns0000b
like in this article - only in some case C. pneumoniae run together with Chlamydia trachomatis

And also in this - in few case C. pneumoniae run together with Chlamydia trachomatis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/

So in conclusion C. pneumoniae is no a risk factor for Chlamydia trachomatis reactive arthritis !

3. Mycoplasma homini rare cause reactive arthritis - as 50 % of healthy woman and man carry it with no problem - an only in few cases of reactive arthritis with Mycoplasma homini

Thank you very much !






doctor
Answered by Dr. Sankaranantham Murugan (20 hours later)
Brief Answer:
Your points are well appreciated

Detailed Answer:
Hi,
welcome back.
Even though the symptoms of DIL (Drug induced lupus) resolve within few weeks of drug discontinuation, the autoantibodies can stay positive for several months to years, and their presence alone shall be a reason to use anti-inflammatory or immunosuppressive therapy.
Drug-induced lupus carries a favorable prognosis with less morbidity and mortality as compared to SLE. In most cases, DIL resolves within a few weeks after discontinuation of the drug, with rare patients needing treatment for several months. (https://www.ncbi.nlm.nih.gov/books/NBK441889/#:~:text=Drug%2Dinduced%20lupus%20erythematosus%20(DIL,the%20diagnosis%20can%20be%20challenging.)
I agree that chlamydia trachomatis is responsible for reactive Arthritis, not other types of Chlamydia.
I had not come across a case of Reactive arthritis due to mycoplasma so far in my practice.
Thank you for your information and is useful..
Dr S. Murugan


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sankaranantham Murugan (4 hours later)
Thank you !

1.But in this article what you sent me it is said - that severe forms are rare - and longer treatment rare
So in conclusion - DIL will go away - on anti inflammation drugs may be needed for some time

In most cases, DIL resolves within a few weeks after discontinuation of the drug, with rare patients needing treatment for several months. Life-threatening disease is infrequent.

https://www.ncbi.nlm.nih.gov/books/NBK441889/


For severe symptoms, such as pleuropericarditis, severe arthritis, or DIL that affects the neurologic and renal systems, high-dose systemic corticosteroids can be given for 2 to 10 weeks.

https://www.uspharmacist.com/article/identifying-drug-induced-lupus

2. Other question - in one article it is said that 1 in 8 woman will have Pelvic inflammatory disease

But it is not logic as all of them should get STD like Chlamydia - but most of young woman dont get such STD

as 10 % of STD will get Pelvic inflammatory disease

This statesmen that 1 in 8 will get Pelvic inflammatory disease is not logic

as in CDC there was one article about Pelvic inflammatory disease - only for thous who get STD

https://www.cdc.gov/mmwr/volumes/66/wr/mm6603a3.htm

3. it is said in one article Mycoplasma hominis affects up to 50% of sexually active males and females
what does it mean - that it cause some inflammation - or just it live as normal fauna !
It is like to Mycoplasma hominis test - so it could be a marketing trick. Mycoplasma hominis live in human body and only sometimes cause some problems !

Mycoplasma hominis affects up to 50% of sexually active males and females. The bacterium is present in almost everyone’s urinary tract in small quantities. Higher quantities cause the infection which can be transmitted sexually.

Thank you very much !



doctor
Answered by Dr. Sankaranantham Murugan (17 hours later)
Brief Answer:
Let us follow standard guidelines, Not to get confused by various studies

Detailed Answer:
Hi,
Welcome back.
You are analyzing the facts very well.
Outcome of the studies may differ from region to region and according to their methodology.
We, clinicians, are not looking the outcome of various studies, but follow the guidelines of CDC of US or WHO or Our own country's health department guidelines.
So don't get confused by various studies.
Pelvic inflammatory disease will not follow all the STIs, but with the organisms those can cause cervicitis in women, like Chlamydia trachomatis, ureaplasma urealyticum and mycoplama Homnis and genitalium.
Dr S. Murugan
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sankaranantham Murugan (2 days later)
Than you

About 1. question

In most cases, DIL resolves within a few weeks after discontinuation of the drug, with rare patients needing treatment for several months. Life-threatening disease is infrequent.
it is so ?

3. Question
it is said in one article Mycoplasma hominis affects up to 50% of sexually active males and females
what does it mean - that it cause some inflammation - or just it live as normal fauna !
It is like to Mycoplasma hominis test - so it could be a marketing trick. Mycoplasma hominis live in human body and only sometimes cause some problems !


https://www.confidantetest.com/mycoplasma-hominis/



doctor
Answered by Dr. Sankaranantham Murugan (29 hours later)
Brief Answer:
Not necessary to research much online. Follow your doctor's advice

Detailed Answer:
Hi,
welcome back.
1. True
2. Mycoplasma Hominis and Ureaplasma urealyticum are said to be the etiology in 30-35% of Nongonococcal genital infections.
In our country we don't have much facilities to test for Mycoplasma Hominis in our country. So we don't have enough statistics to tell correctly. We used to treat both Chlamydia and Mycoplasma if we suspect Nongonococcal genital infection. I don't think Mycoplasma is not a regular part of the flora in genitals!
Dr S. Murugan
Note: Consult a Sexual Diseases Specialist online for further follow up- Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Sankaranantham Murugan

HIV AIDS Specialist

Practicing since :1974

Answered : 3113 Questions

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Hello ! I Have Question Does CHLAMYDIA TRACHOMATIS INFECTION A

Brief Answer: SLE triggered by Chlamydia Infection is remote possibility or a coincidence Detailed Answer: Hi, Welcome to ASK A DOCTOR through HCM. Thanks for posting your query. Nearly 4 million cases of chlamydial infections per annum are reported in US alone. Imagine the load of infections across the whole world. SLE is known entity and autoimmune disorder widely prevalent worldwide. It can be triggered through various drugs and diseases. But I had come across a single case triggered by chlamydial infection or suspected to be so far in my 45 years of experience. Reiter's disease is the one established to be triggered by Chlamydia Trachomatis nongonococcal infection. Medicine is not mathematics to get a constant answer. Possibility of chlamydia triggering SLE cannot be ruled out. Dr S.Murugan