Are Cramps, Sore Breasts, And Constipation Due To Duphaston Or PMS?

Hi! I had my trigger shot on 14th of Dec 2020 at that time one of my follicle size was 24. My doctor told me to start estradiol that very day 3 times a day and then on 17th to start duphaston 2 times a day. Since last week I have been getting mild abdominal cramps, my right eye was twitching for first three days then it stopped. Consitpated as well and breast are a but sore when touched. UPT was negative yesterday. Have i tested early or all the above side effects of duphaston or maybe PMS. I am due for my period tomorrow. Please help.